Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5

Detalhes bibliográficos
Ano de defesa: 2014
Autor(a) principal: Novais, Juliana Bueno de [UNESP]
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Estadual Paulista (Unesp)
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://hdl.handle.net/11449/128098
http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/16-09-2015/000848970.pdf
Resumo: Bovine Herpesvirus type 5 (BoHV-5) and bovine herpesvirus type 1 (BoHV-1), members of Herpesviridae family, Alphaherpesvirinae subfamily; may replicate in different tissues such as nervous, glandular, lymphoid and parenchymal organs and are able to remain in a latent state, lodged in nerve ganglia. In Brazil clinical cases of BoHV - 5 encephalitis are the second leading cause of death due to encephalitis with determined etiology, supplanted only by rabies, while the BoHV-1 is present in an endemic form in the national herd, being responsible for a variety of clinical signs as rhinotracheitis, abortion, conjunctivitis, vulvovaginitis and balanoposthitis. It is expected that a viral agent, to infect a cell, activate the pathways of programmed cell death process, however there are reports that the gene related to latency (RL) of Herpesvirus is able to inhibit cell apoptosis, protecting the infected cell during latency through unknown mechanisms. Therefore, this study demonstrated the capacity of BoHV-5 and BoHV-1 to manipulate mitochondrial metabolism of the infected cell, interfering with intrinsic pathway of apoptosis
id UNSP_5888b41a6aea101cae8a70522a557fff
oai_identifier_str oai:repositorio.unesp.br:11449/128098
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str
spelling Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5Virus do herpes em animaisMorte celularBovinoBovino - InfecçõesApoptoseAlphaherpesvirinaeBovine Herpesvirus type 5 (BoHV-5) and bovine herpesvirus type 1 (BoHV-1), members of Herpesviridae family, Alphaherpesvirinae subfamily; may replicate in different tissues such as nervous, glandular, lymphoid and parenchymal organs and are able to remain in a latent state, lodged in nerve ganglia. In Brazil clinical cases of BoHV - 5 encephalitis are the second leading cause of death due to encephalitis with determined etiology, supplanted only by rabies, while the BoHV-1 is present in an endemic form in the national herd, being responsible for a variety of clinical signs as rhinotracheitis, abortion, conjunctivitis, vulvovaginitis and balanoposthitis. It is expected that a viral agent, to infect a cell, activate the pathways of programmed cell death process, however there are reports that the gene related to latency (RL) of Herpesvirus is able to inhibit cell apoptosis, protecting the infected cell during latency through unknown mechanisms. Therefore, this study demonstrated the capacity of BoHV-5 and BoHV-1 to manipulate mitochondrial metabolism of the infected cell, interfering with intrinsic pathway of apoptosisFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista (Unesp)Silva, Tereza Cristina Cardoso [UNESP]Universidade Estadual Paulista (Unesp)Novais, Juliana Bueno de [UNESP]2015-10-06T13:03:17Z2015-10-06T13:03:17Z2014-01-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis37 f.application/pdfNOVAIS, Juliana Bueno de. Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5. 2014. 37 f. , 2014.http://hdl.handle.net/11449/128098000848970http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/16-09-2015/000848970.pdf33004021075P8Alephreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporinfo:eu-repo/semantics/openAccess2024-01-01T06:22:21Zoai:repositorio.unesp.br:11449/128098Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:52:50.950541Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5
title Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5
spellingShingle Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5
Novais, Juliana Bueno de [UNESP]
Virus do herpes em animais
Morte celular
Bovino
Bovino - Infecções
Apoptose
Alphaherpesvirinae
title_short Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5
title_full Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5
title_fullStr Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5
title_full_unstemmed Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5
title_sort Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5
author Novais, Juliana Bueno de [UNESP]
author_facet Novais, Juliana Bueno de [UNESP]
author_role author
dc.contributor.none.fl_str_mv Silva, Tereza Cristina Cardoso [UNESP]
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Novais, Juliana Bueno de [UNESP]
dc.subject.por.fl_str_mv Virus do herpes em animais
Morte celular
Bovino
Bovino - Infecções
Apoptose
Alphaherpesvirinae
topic Virus do herpes em animais
Morte celular
Bovino
Bovino - Infecções
Apoptose
Alphaherpesvirinae
description Bovine Herpesvirus type 5 (BoHV-5) and bovine herpesvirus type 1 (BoHV-1), members of Herpesviridae family, Alphaherpesvirinae subfamily; may replicate in different tissues such as nervous, glandular, lymphoid and parenchymal organs and are able to remain in a latent state, lodged in nerve ganglia. In Brazil clinical cases of BoHV - 5 encephalitis are the second leading cause of death due to encephalitis with determined etiology, supplanted only by rabies, while the BoHV-1 is present in an endemic form in the national herd, being responsible for a variety of clinical signs as rhinotracheitis, abortion, conjunctivitis, vulvovaginitis and balanoposthitis. It is expected that a viral agent, to infect a cell, activate the pathways of programmed cell death process, however there are reports that the gene related to latency (RL) of Herpesvirus is able to inhibit cell apoptosis, protecting the infected cell during latency through unknown mechanisms. Therefore, this study demonstrated the capacity of BoHV-5 and BoHV-1 to manipulate mitochondrial metabolism of the infected cell, interfering with intrinsic pathway of apoptosis
publishDate 2014
dc.date.none.fl_str_mv 2014-01-22
2015-10-06T13:03:17Z
2015-10-06T13:03:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv NOVAIS, Juliana Bueno de. Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5. 2014. 37 f. , 2014.
http://hdl.handle.net/11449/128098
000848970
http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/16-09-2015/000848970.pdf
33004021075P8
identifier_str_mv NOVAIS, Juliana Bueno de. Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5. 2014. 37 f. , 2014.
000848970
33004021075P8
url http://hdl.handle.net/11449/128098
http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/16-09-2015/000848970.pdf
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 37 f.
application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.source.none.fl_str_mv Aleph
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808130297840009216