Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5
Ano de defesa: | 2014 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Estadual Paulista (Unesp)
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Programa de Pós-Graduação: |
Não Informado pela instituição
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Departamento: |
Não Informado pela instituição
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País: |
Não Informado pela instituição
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Palavras-chave em Português: | |
Link de acesso: | http://hdl.handle.net/11449/128098 http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/16-09-2015/000848970.pdf |
Resumo: | Bovine Herpesvirus type 5 (BoHV-5) and bovine herpesvirus type 1 (BoHV-1), members of Herpesviridae family, Alphaherpesvirinae subfamily; may replicate in different tissues such as nervous, glandular, lymphoid and parenchymal organs and are able to remain in a latent state, lodged in nerve ganglia. In Brazil clinical cases of BoHV - 5 encephalitis are the second leading cause of death due to encephalitis with determined etiology, supplanted only by rabies, while the BoHV-1 is present in an endemic form in the national herd, being responsible for a variety of clinical signs as rhinotracheitis, abortion, conjunctivitis, vulvovaginitis and balanoposthitis. It is expected that a viral agent, to infect a cell, activate the pathways of programmed cell death process, however there are reports that the gene related to latency (RL) of Herpesvirus is able to inhibit cell apoptosis, protecting the infected cell during latency through unknown mechanisms. Therefore, this study demonstrated the capacity of BoHV-5 and BoHV-1 to manipulate mitochondrial metabolism of the infected cell, interfering with intrinsic pathway of apoptosis |
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Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5Virus do herpes em animaisMorte celularBovinoBovino - InfecçõesApoptoseAlphaherpesvirinaeBovine Herpesvirus type 5 (BoHV-5) and bovine herpesvirus type 1 (BoHV-1), members of Herpesviridae family, Alphaherpesvirinae subfamily; may replicate in different tissues such as nervous, glandular, lymphoid and parenchymal organs and are able to remain in a latent state, lodged in nerve ganglia. In Brazil clinical cases of BoHV - 5 encephalitis are the second leading cause of death due to encephalitis with determined etiology, supplanted only by rabies, while the BoHV-1 is present in an endemic form in the national herd, being responsible for a variety of clinical signs as rhinotracheitis, abortion, conjunctivitis, vulvovaginitis and balanoposthitis. It is expected that a viral agent, to infect a cell, activate the pathways of programmed cell death process, however there are reports that the gene related to latency (RL) of Herpesvirus is able to inhibit cell apoptosis, protecting the infected cell during latency through unknown mechanisms. Therefore, this study demonstrated the capacity of BoHV-5 and BoHV-1 to manipulate mitochondrial metabolism of the infected cell, interfering with intrinsic pathway of apoptosisFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista (Unesp)Silva, Tereza Cristina Cardoso [UNESP]Universidade Estadual Paulista (Unesp)Novais, Juliana Bueno de [UNESP]2015-10-06T13:03:17Z2015-10-06T13:03:17Z2014-01-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis37 f.application/pdfNOVAIS, Juliana Bueno de. Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5. 2014. 37 f. , 2014.http://hdl.handle.net/11449/128098000848970http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/16-09-2015/000848970.pdf33004021075P8Alephreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporinfo:eu-repo/semantics/openAccess2024-01-01T06:22:21Zoai:repositorio.unesp.br:11449/128098Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:52:50.950541Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5 |
title |
Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5 |
spellingShingle |
Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5 Novais, Juliana Bueno de [UNESP] Virus do herpes em animais Morte celular Bovino Bovino - Infecções Apoptose Alphaherpesvirinae |
title_short |
Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5 |
title_full |
Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5 |
title_fullStr |
Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5 |
title_full_unstemmed |
Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5 |
title_sort |
Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5 |
author |
Novais, Juliana Bueno de [UNESP] |
author_facet |
Novais, Juliana Bueno de [UNESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Silva, Tereza Cristina Cardoso [UNESP] Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Novais, Juliana Bueno de [UNESP] |
dc.subject.por.fl_str_mv |
Virus do herpes em animais Morte celular Bovino Bovino - Infecções Apoptose Alphaherpesvirinae |
topic |
Virus do herpes em animais Morte celular Bovino Bovino - Infecções Apoptose Alphaherpesvirinae |
description |
Bovine Herpesvirus type 5 (BoHV-5) and bovine herpesvirus type 1 (BoHV-1), members of Herpesviridae family, Alphaherpesvirinae subfamily; may replicate in different tissues such as nervous, glandular, lymphoid and parenchymal organs and are able to remain in a latent state, lodged in nerve ganglia. In Brazil clinical cases of BoHV - 5 encephalitis are the second leading cause of death due to encephalitis with determined etiology, supplanted only by rabies, while the BoHV-1 is present in an endemic form in the national herd, being responsible for a variety of clinical signs as rhinotracheitis, abortion, conjunctivitis, vulvovaginitis and balanoposthitis. It is expected that a viral agent, to infect a cell, activate the pathways of programmed cell death process, however there are reports that the gene related to latency (RL) of Herpesvirus is able to inhibit cell apoptosis, protecting the infected cell during latency through unknown mechanisms. Therefore, this study demonstrated the capacity of BoHV-5 and BoHV-1 to manipulate mitochondrial metabolism of the infected cell, interfering with intrinsic pathway of apoptosis |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-22 2015-10-06T13:03:17Z 2015-10-06T13:03:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
NOVAIS, Juliana Bueno de. Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5. 2014. 37 f. , 2014. http://hdl.handle.net/11449/128098 000848970 http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/16-09-2015/000848970.pdf 33004021075P8 |
identifier_str_mv |
NOVAIS, Juliana Bueno de. Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5. 2014. 37 f. , 2014. 000848970 33004021075P8 |
url |
http://hdl.handle.net/11449/128098 http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/16-09-2015/000848970.pdf |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
37 f. application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.source.none.fl_str_mv |
Aleph reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808130297840009216 |