Efeito da suplementação com boro no metabolismo ósseo de camundongos diabéticos não obesos

• Ano de defesa: 2015
• Autor(a) principal: Dessordi, Renata [UNESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Osteoblastos; Osteoclastos; Boro; Metabolismo; Diabetes mellitus
• Link de acesso: http://hdl.handle.net/11449/132573; http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/22-12-2015/000856329.pdf

The role of nutrition in the development of the bone tissue has been the focus of many studies. Diabetes Mellitus is an illness that deregulates the activity of osteoblasts and osteoclasts, predisposes a higher risk for the development of osteoporosis. Thus, the objective this study was investigates the influence of a boron supplementation on bone metabolism of control and non-obese diabetic mice for 30 days. The animals were supplemented with 40 μg/0,5 ml of boron solution (boron chelate H 5%). We evaluated the possible bone changes during the development of complications caused by diabetes for biochemical parameters, total calcium, inorganic phosphorus, magnesium and boron, bone analysis (bone computed microtomography, and biomechanical assay at three point test in tibia and femur). This study consisted of 28 animals divided in four groups: Group water control (n=10): received 0,5 mL/day of distilled water, Group boron control (n=8): received 0,5 ml/day of boron, Group diabetic water (n=5): received 0,5 mL/day of distilled water and Group diabetic boron (n=5): received 0,5 mL/day of boron. The results showed that bone volume for the DB group was significant higher compared with CA and DA. In relation to trabecular bone, volume fraction was higher for the CB group when compared with CA and DA. The values for specific bone surface were higher for the DB group compared with CA. The trabecular thickness and structure model index were significantly different for the CB, CA when compared with DA group. The boron serum dosages were higher for DB group compared with CA and DA. The magnesium concentration was lower for DA and DB compared with CA and CB group. Biomechanical test revealed maintenance of parameters the bone strength in animals DB compared with the DA group and controls. Thus, the results suggest that boron supplementation can improve parameters related to bone strength and microstructure of cortical and trabecular bone in diabetic ...