Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivar

Detalhes bibliográficos
Ano de defesa: 2025
Autor(a) principal: Mateus, Alanna Ramalho [UNESP]
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Estadual Paulista (Unesp)
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Saliva
Cáries dentárias
Marcadores bioquímicos
Proteínas salivares
Oxido nitrico
Tratamento odontológico restaurador sem trauma
Dental caries
Link de acesso: https://hdl.handle.net/11449/296292
http://lattes.cnpq.br/5961697725835498
Resumo: Saliva contains oxidative stress biomarkers, whose expression may be altered by the presence of caries. This study evaluated whether atraumatic restorative treatment (art) alters the concentration of total proteins and nitric oxide in the saliva of children with caries at different stages. A total of 45 children, aged 4 to 6 years, attending EMEB schools in Araçatuba, SP, were selected and divided into three groups: caries-free, enamel caries, and dentin caries. Unstimulated saliva samples were collected before, immediately after, and 21 days after clinical treatment, in which carious lesions were restored with glass ionomer cement. The collection protocol restricted the use of fluoridated products. Pre-standardized biochemical experiments were conducted to assess the concentration of total proteins and salivary nitrite (no₂⁻).. Art did not alter salivary nitrite (no₂⁻) concentration in children with caries, but increased total protein concentration, with noticeable effects 21 days after the intervention, particularly in children with dentin caries. These findings indicate that art modifies the oral environment, emphasizing the importance of integrating research, education, and clinical strategies to optimize caries prevention and control.
id UNSP_fb972d51323c1fcd003510070c835f33
oai_identifier_str oai:repositorio.unesp.br:11449/296292
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str
spelling Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivarEvaluation of the effect of atraumatic restorative treatment of caries lesions on total protein concentration and salivary nitric oxide concentrationSalivaCáries dentáriasMarcadores bioquímicosProteínas salivaresOxido nitricoTratamento odontológico restaurador sem traumaDental cariesSaliva contains oxidative stress biomarkers, whose expression may be altered by the presence of caries. This study evaluated whether atraumatic restorative treatment (art) alters the concentration of total proteins and nitric oxide in the saliva of children with caries at different stages. A total of 45 children, aged 4 to 6 years, attending EMEB schools in Araçatuba, SP, were selected and divided into three groups: caries-free, enamel caries, and dentin caries. Unstimulated saliva samples were collected before, immediately after, and 21 days after clinical treatment, in which carious lesions were restored with glass ionomer cement. The collection protocol restricted the use of fluoridated products. Pre-standardized biochemical experiments were conducted to assess the concentration of total proteins and salivary nitrite (no₂⁻).. Art did not alter salivary nitrite (no₂⁻) concentration in children with caries, but increased total protein concentration, with noticeable effects 21 days after the intervention, particularly in children with dentin caries. These findings indicate that art modifies the oral environment, emphasizing the importance of integrating research, education, and clinical strategies to optimize caries prevention and control.Saliva contains oxidative stress biomarkers, whose expression may be altered by the presence of caries. This study evaluated whether atraumatic restorative treatment (art) alters the concentration of total proteins and nitric oxide in the saliva of children with caries at different stages. A total of 45 children, aged 4 to 6 years, attending EMEB schools in Araçatuba, SP, were selected and divided into three groups: caries-free, enamel caries, and dentin caries. Unstimulated saliva samples were collected before, immediately after, and 21 days after clinical treatment, in which carious lesions were restored with glass ionomer cement. The collection protocol restricted the use of fluoridated products. Pre-standardized biochemical experiments were conducted to assess the concentration of total proteins and salivary nitrite (no₂⁻).. Art did not alter salivary nitrite (no₂⁻) concentration in children with caries, but increased total protein concentration, with noticeable effects 21 days after the intervention, particularly in children with dentin caries. These findings indicate that art modifies the oral environment, emphasizing the importance of integrating research, education, and clinical strategies to optimize caries prevention and control.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação para o Desenvolvimento da UNESP (FUNDUNESP)CAPES: 001Universidade Estadual Paulista (Unesp)Silva, Cristina Antoniali [UNESP]Universidade Estadual Paulista (Unesp)Chaves Neto, Antonio Hernandes [UNESP]Mateus, Alanna Ramalho [UNESP]2025-04-10T13:58:50Z2025-03-28info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfMATEUS, A. R. Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivar. 2025. Dissertação Mestrado – Faculdade de Odontologia, Universidade Estadual Paulista (UNESP), Araçatuba, 2025.https://hdl.handle.net/11449/29629233004021073P5http://lattes.cnpq.br/59616977258354980009-0002-9727-195Xporinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESP2025-06-02T18:41:32Zoai:repositorio.unesp.br:11449/296292Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-06-02T18:41:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivar
Evaluation of the effect of atraumatic restorative treatment of caries lesions on total protein concentration and salivary nitric oxide concentration
title Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivar
spellingShingle Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivar
Mateus, Alanna Ramalho [UNESP]
Saliva
Cáries dentárias
Marcadores bioquímicos
Proteínas salivares
Oxido nitrico
Tratamento odontológico restaurador sem trauma
Dental caries
title_short Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivar
title_full Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivar
title_fullStr Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivar
title_full_unstemmed Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivar
title_sort Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivar
author Mateus, Alanna Ramalho [UNESP]
author_facet Mateus, Alanna Ramalho [UNESP]
author_role author
dc.contributor.none.fl_str_mv Silva, Cristina Antoniali [UNESP]
Universidade Estadual Paulista (Unesp)
Chaves Neto, Antonio Hernandes [UNESP]
dc.contributor.author.fl_str_mv Mateus, Alanna Ramalho [UNESP]
dc.subject.por.fl_str_mv Saliva
Cáries dentárias
Marcadores bioquímicos
Proteínas salivares
Oxido nitrico
Tratamento odontológico restaurador sem trauma
Dental caries
topic Saliva
Cáries dentárias
Marcadores bioquímicos
Proteínas salivares
Oxido nitrico
Tratamento odontológico restaurador sem trauma
Dental caries
description Saliva contains oxidative stress biomarkers, whose expression may be altered by the presence of caries. This study evaluated whether atraumatic restorative treatment (art) alters the concentration of total proteins and nitric oxide in the saliva of children with caries at different stages. A total of 45 children, aged 4 to 6 years, attending EMEB schools in Araçatuba, SP, were selected and divided into three groups: caries-free, enamel caries, and dentin caries. Unstimulated saliva samples were collected before, immediately after, and 21 days after clinical treatment, in which carious lesions were restored with glass ionomer cement. The collection protocol restricted the use of fluoridated products. Pre-standardized biochemical experiments were conducted to assess the concentration of total proteins and salivary nitrite (no₂⁻).. Art did not alter salivary nitrite (no₂⁻) concentration in children with caries, but increased total protein concentration, with noticeable effects 21 days after the intervention, particularly in children with dentin caries. These findings indicate that art modifies the oral environment, emphasizing the importance of integrating research, education, and clinical strategies to optimize caries prevention and control.
publishDate 2025
dc.date.none.fl_str_mv 2025-04-10T13:58:50Z
2025-03-28
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv MATEUS, A. R. Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivar. 2025. Dissertação Mestrado – Faculdade de Odontologia, Universidade Estadual Paulista (UNESP), Araçatuba, 2025.
https://hdl.handle.net/11449/296292
33004021073P5
http://lattes.cnpq.br/5961697725835498
0009-0002-9727-195X
identifier_str_mv MATEUS, A. R. Avaliação do efeito do tratamento restaurador atraumático das lesões de cárie sobre a concentração de proteínas totais e a concentração de óxido nítrico salivar. 2025. Dissertação Mestrado – Faculdade de Odontologia, Universidade Estadual Paulista (UNESP), Araçatuba, 2025.
33004021073P5
0009-0002-9727-195X
url https://hdl.handle.net/11449/296292
http://lattes.cnpq.br/5961697725835498
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1854954967733895168

Registros relacionados