Análise de agrupamento para classificação de fontes usadas na braquiterapia intravascular
Ano de defesa: | 2008 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal Rural de Pernambuco
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Biometria e Estatística Aplicada
|
Departamento: |
Departamento de Estatística e Informática
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5223 |
Resumo: | There are several factors that are responsible for the most deaths caused by cardiovascular diseases, which are growing in almost all countries of the world. Acute myocardial infarction (AMI) is the one that occurs with the greatest extent, originating from the partial or total occlusion of one or more coronary arteries – the atherosclerosis. Throughout the years, various techniques were implemented to diagnose as well as to treat coronary diseases. In the search for a better quality of life and a less invasive treatment than the traditional surgeries for myocardial revascularization, angioplasty is applicable. Unfortunately, around 30% of the patients treated with angioplasty, in a period of just six months, come back to treatment due to restenosis – a reoccurrence of the narrowing or blockage in the blood vessel. Nowadays, Intravascular Brachytherapy – a technique with intravenous radiation – is the method of choice as it handles this phase in a satisfactory way, for it is observed the receding of the proliferative metabolism of restenosis. Thus, with the aim for radiological protection of both patients and professionals involved in the therapy, the distribution of doses for the monoenergetic electrons and photons were calculated for blood vessels of 4.5, 3.0 and 1.5 mm of diameter in several sources, using the MCNP4B code. In this context, the goal of this work was to classify theradioactive sources used in Intravascular Brachytherapy by employing Cluster Analyses with related dendograms and Cophenetic Correlation Coefficients. The results showed that the hierarchical techniques were effective in the classification of the electron-emitting radioactive sources (Cophenetic Correlation Coefficients varied from 0.81 to 0.99), whereas for the photons these techniques were not satisfactory (Cophenetic Correlation Coefficients varied from 0.64 to 0.78). |
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SANTOS, Laélia Pumilla Botêlho Campos dosCRUZ, Maria Adélia Oliveira Monteiro daMENDES, Paulo de PaulaSTOSIC, TatijanaSILVA, Edvane Borges daCYSNEIROS, Francisco José de Azevedohttp://lattes.cnpq.br/5437758365033397CABRAL, Moacy Vasconcelos2016-08-08T15:17:09Z2008-02-28CABRAL, Moacy Vasconcelos. Análise de agrupamento para classificação de fontes usadas na braquiterapia intravascular. 2008. 62 f. Dissertação (Programa de Pós-Graduação em Biometria e Estatística Aplicada) - Universidade Federal Rural de Pernambuco, Recife.http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5223There are several factors that are responsible for the most deaths caused by cardiovascular diseases, which are growing in almost all countries of the world. Acute myocardial infarction (AMI) is the one that occurs with the greatest extent, originating from the partial or total occlusion of one or more coronary arteries – the atherosclerosis. Throughout the years, various techniques were implemented to diagnose as well as to treat coronary diseases. In the search for a better quality of life and a less invasive treatment than the traditional surgeries for myocardial revascularization, angioplasty is applicable. Unfortunately, around 30% of the patients treated with angioplasty, in a period of just six months, come back to treatment due to restenosis – a reoccurrence of the narrowing or blockage in the blood vessel. Nowadays, Intravascular Brachytherapy – a technique with intravenous radiation – is the method of choice as it handles this phase in a satisfactory way, for it is observed the receding of the proliferative metabolism of restenosis. Thus, with the aim for radiological protection of both patients and professionals involved in the therapy, the distribution of doses for the monoenergetic electrons and photons were calculated for blood vessels of 4.5, 3.0 and 1.5 mm of diameter in several sources, using the MCNP4B code. In this context, the goal of this work was to classify theradioactive sources used in Intravascular Brachytherapy by employing Cluster Analyses with related dendograms and Cophenetic Correlation Coefficients. The results showed that the hierarchical techniques were effective in the classification of the electron-emitting radioactive sources (Cophenetic Correlation Coefficients varied from 0.81 to 0.99), whereas for the photons these techniques were not satisfactory (Cophenetic Correlation Coefficients varied from 0.64 to 0.78).Existem vários fatores que são responsáveis pela grande maioria das mortes causadas por doenças cardiovasculares as quais são crescente em quase todos os países do mundo, sendo o infarto agudo do miocárdio (IAM) a que ocorre com maior destaque, oriundo de oclusão parcial ou total de uma ou mais artérias coronárias (a aterosclerose). Atualmente, vêm sendo aplicadas diversas técnicas tanto para diagnosticar quanto para tratar a doença coronariana. Buscando uma melhor qualidade de vida e um tratamento menos invasivo do que as tradicionais cirurgias de revascularização do miocárdio, emprega-se a angioplastia coronária. Lamentavelmente, em torno de 30% dos pacientes tratados por angioplastia, em um período de apenas seis meses, voltam ao médico devido à reestenose (reestreitamento da artéria). Recentemente, a braquiterapia intravascular (terapia com radiação intravaso) vem sendo bastante útil no retardo do metabolismo proliferativo da reestenose. Dessa forma, visando à proteção radiológica dos pacientes e profissionais envolvidos nesta terapia, cálculos de dose foram realizados em vasos sanguíneos de 4,5, 3,0 e 1,5 mm de diâmetro para diversas fontes de radiação,usando o código MCNP4B. Neste contexto, o objetivo do presente trabalho foi o de classificar fontes radioativas usadas na Braquiterapia Intravascular utilizando a análise de agrupamento, por meio de dendograma e Correlação Cofenética associados. Os resultados mostraram que as técnicas hierárquicas foram eficientes na classificação das fontes radioativas emissoras de elétrons (as Correlações Cofenéticas variaram de 0,81 a 0,99), enquanto que para os fótons essas técnicas não foram satisfatórias (as Correlações Cofenéticas variaram de 0,64 a 0,78).Submitted by (ana.araujo@ufrpe.br) on 2016-08-08T15:17:09Z No. of bitstreams: 1 Moacy Vasconcelos Cabral.pdf: 608103 bytes, checksum: 99d5c81824432310afaa742f16c76e41 (MD5)Made available in DSpace on 2016-08-08T15:17:09Z (GMT). No. of bitstreams: 1 Moacy Vasconcelos Cabral.pdf: 608103 bytes, checksum: 99d5c81824432310afaa742f16c76e41 (MD5) Previous issue date: 2008-02-28application/pdfporUniversidade Federal Rural de PernambucoPrograma de Pós-Graduação em Biometria e Estatística AplicadaUFRPEBrasilDepartamento de Estatística e InformáticaAnálise de agrupamentoTécnicas hierárquicasDendogramasBraquiterapia intravascularCluster analysisHierarchical techniquesIntravascular brachytherapyDendogramsCIENCIAS EXATAS E DA TERRA::PROBABILIDADE E ESTATISTICAAnálise de agrupamento para classificação de fontes usadas na braquiterapia intravascularinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis768382242446187918600600600-6774555140396120501-5836407828185143517info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRPEinstname:Universidade Federal Rural de Pernambuco (UFRPE)instacron:UFRPELICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://www.tede2.ufrpe.br:8080/tede2/bitstream/tede2/5223/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51ORIGINALMoacy Vasconcelos Cabral.pdfMoacy Vasconcelos Cabral.pdfapplication/pdf608103http://www.tede2.ufrpe.br:8080/tede2/bitstream/tede2/5223/2/Moacy+Vasconcelos+Cabral.pdf99d5c81824432310afaa742f16c76e41MD52tede2/52232016-08-08 12:17:09.852oai:tede2: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Biblioteca Digital de Teses e Dissertaçõeshttp://www.tede2.ufrpe.br:8080/tede/PUBhttp://www.tede2.ufrpe.br:8080/oai/requestbdtd@ufrpe.br ||bdtd@ufrpe.bropendoar:2024-05-28T12:32:46.002880Biblioteca Digital de Teses e Dissertações da UFRPE - Universidade Federal Rural de Pernambuco (UFRPE)false |
dc.title.por.fl_str_mv |
Análise de agrupamento para classificação de fontes usadas na braquiterapia intravascular |
title |
Análise de agrupamento para classificação de fontes usadas na braquiterapia intravascular |
spellingShingle |
Análise de agrupamento para classificação de fontes usadas na braquiterapia intravascular CABRAL, Moacy Vasconcelos Análise de agrupamento Técnicas hierárquicas Dendogramas Braquiterapia intravascular Cluster analysis Hierarchical techniques Intravascular brachytherapy Dendograms CIENCIAS EXATAS E DA TERRA::PROBABILIDADE E ESTATISTICA |
title_short |
Análise de agrupamento para classificação de fontes usadas na braquiterapia intravascular |
title_full |
Análise de agrupamento para classificação de fontes usadas na braquiterapia intravascular |
title_fullStr |
Análise de agrupamento para classificação de fontes usadas na braquiterapia intravascular |
title_full_unstemmed |
Análise de agrupamento para classificação de fontes usadas na braquiterapia intravascular |
title_sort |
Análise de agrupamento para classificação de fontes usadas na braquiterapia intravascular |
author |
CABRAL, Moacy Vasconcelos |
author_facet |
CABRAL, Moacy Vasconcelos |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
SANTOS, Laélia Pumilla Botêlho Campos dos |
dc.contributor.advisor-co1.fl_str_mv |
CRUZ, Maria Adélia Oliveira Monteiro da |
dc.contributor.advisor-co2.fl_str_mv |
MENDES, Paulo de Paula |
dc.contributor.referee1.fl_str_mv |
STOSIC, Tatijana |
dc.contributor.referee2.fl_str_mv |
SILVA, Edvane Borges da |
dc.contributor.referee3.fl_str_mv |
CYSNEIROS, Francisco José de Azevedo |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5437758365033397 |
dc.contributor.author.fl_str_mv |
CABRAL, Moacy Vasconcelos |
contributor_str_mv |
SANTOS, Laélia Pumilla Botêlho Campos dos CRUZ, Maria Adélia Oliveira Monteiro da MENDES, Paulo de Paula STOSIC, Tatijana SILVA, Edvane Borges da CYSNEIROS, Francisco José de Azevedo |
dc.subject.por.fl_str_mv |
Análise de agrupamento Técnicas hierárquicas Dendogramas Braquiterapia intravascular |
topic |
Análise de agrupamento Técnicas hierárquicas Dendogramas Braquiterapia intravascular Cluster analysis Hierarchical techniques Intravascular brachytherapy Dendograms CIENCIAS EXATAS E DA TERRA::PROBABILIDADE E ESTATISTICA |
dc.subject.eng.fl_str_mv |
Cluster analysis Hierarchical techniques Intravascular brachytherapy Dendograms |
dc.subject.cnpq.fl_str_mv |
CIENCIAS EXATAS E DA TERRA::PROBABILIDADE E ESTATISTICA |
description |
There are several factors that are responsible for the most deaths caused by cardiovascular diseases, which are growing in almost all countries of the world. Acute myocardial infarction (AMI) is the one that occurs with the greatest extent, originating from the partial or total occlusion of one or more coronary arteries – the atherosclerosis. Throughout the years, various techniques were implemented to diagnose as well as to treat coronary diseases. In the search for a better quality of life and a less invasive treatment than the traditional surgeries for myocardial revascularization, angioplasty is applicable. Unfortunately, around 30% of the patients treated with angioplasty, in a period of just six months, come back to treatment due to restenosis – a reoccurrence of the narrowing or blockage in the blood vessel. Nowadays, Intravascular Brachytherapy – a technique with intravenous radiation – is the method of choice as it handles this phase in a satisfactory way, for it is observed the receding of the proliferative metabolism of restenosis. Thus, with the aim for radiological protection of both patients and professionals involved in the therapy, the distribution of doses for the monoenergetic electrons and photons were calculated for blood vessels of 4.5, 3.0 and 1.5 mm of diameter in several sources, using the MCNP4B code. In this context, the goal of this work was to classify theradioactive sources used in Intravascular Brachytherapy by employing Cluster Analyses with related dendograms and Cophenetic Correlation Coefficients. The results showed that the hierarchical techniques were effective in the classification of the electron-emitting radioactive sources (Cophenetic Correlation Coefficients varied from 0.81 to 0.99), whereas for the photons these techniques were not satisfactory (Cophenetic Correlation Coefficients varied from 0.64 to 0.78). |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-02-28 |
dc.date.accessioned.fl_str_mv |
2016-08-08T15:17:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CABRAL, Moacy Vasconcelos. Análise de agrupamento para classificação de fontes usadas na braquiterapia intravascular. 2008. 62 f. Dissertação (Programa de Pós-Graduação em Biometria e Estatística Aplicada) - Universidade Federal Rural de Pernambuco, Recife. |
dc.identifier.uri.fl_str_mv |
http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5223 |
identifier_str_mv |
CABRAL, Moacy Vasconcelos. Análise de agrupamento para classificação de fontes usadas na braquiterapia intravascular. 2008. 62 f. Dissertação (Programa de Pós-Graduação em Biometria e Estatística Aplicada) - Universidade Federal Rural de Pernambuco, Recife. |
url |
http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5223 |
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por |
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por |
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768382242446187918 |
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600 600 600 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal Rural de Pernambuco |
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Programa de Pós-Graduação em Biometria e Estatística Aplicada |
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UFRPE |
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Brasil |
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Universidade Federal Rural de Pernambuco |
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