A influência dos fármacos no controle da dor decorrente da movimentação dental induzida: uma revisão sistemática

• Ano de defesa: 2016
• Autor(a) principal: Corrêa, Adriano Schalins
• Orientador(a): Lopes, Beatriz Maria Valério
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade do Sagrado Coração
• Programa de Pós-Graduação: Biologia Oral
• Departamento: Ciências da Saúde e Biológicas
• País: Brasil
• Palavras-chave em Português: Anti-inflamatórios; Anti-inflamatórios não esteroides; Ortodontia; Movimentação dentária
• Palavras-chave em Inglês: Anti-inflammatories; Non-steroidal Anti-inflammatories; Orthodontics; Tooth Movement
• Área do conhecimento CNPq: CIENCIAS DA SAUDE::ODONTOLOGIA
• Link de acesso: http://tede2.usc.br:8080/jspui/handle/tede/313

This work aimed to assess, through a systematic review of the literature, the action of non-steroidal anti-inflammatories in the rate of tooth movement, in order to establish which drug has the lower influence on induced tooth movement when administered during treatment. This systematic review was performed according to the PRISMA instructions, with no protocol record since it is a systematic review of studies in animals. A search was performed in PubMed, Scopus, Embase, Web of Science, Google Scholar, LILACS, SciELO, and OpenGrey databases. Google Scholar and OpenGrey were particularly used to search the “grey literature”. Only experimental studies with male Winstar rats were selected, and they should present quantitative and comparative measures regarding the initial and final state of induced tooth movement among groups of animals under and not under non-steroidal anti-inflammatories. Studies in animals with pathological conditions were excluded from the study, as well as articles of literature review, letters to the editor and/or editorials, case reports, abstracts, books, and book chapters. The entire research was performed independently by two reviewers. Aiming to verify the quality of the initial search strategy and the possibility of including more studies in the present review, a manual search was performed among the references present in the selected articles. The total sample included 505 articles, from which six studies remained eligible for qualitative analysis. After the complete triage, texts of the articles selected were reexamined and their data were extracted in a standardized manner. The results show that the studies included present heterogeneity regarding the type of orthodontic device used, anatomic region of installation and teeth involved, type of drug used, concentration, form, and respective administration period. Among nonsteroidal anti-inflammatories assessed, paracetamol did not interfere in tooth movement when compared to the control group. However, drugs such as aspirin, ibuprofen, sodium diclofenac, celecoxib, parecoxib, and rofecoxib showed strong influence regarding the inhibition of cyclooxygenase enzymes, causing the reduction of tooth movement when compared to the control group. However, it may be concluded that paracetamol may be considered the standard choice for pain relief with no interference in induced tooth movement