Use of HH micromixer for the production of PBCA microparticles by emulsion polymerization toward cosmetic application

Detalhes bibliográficos
Ano de defesa: 2024
Autor(a) principal: Vieira, Aline Rocha
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: eng
Instituição de defesa: Biblioteca Digitais de Teses e Dissertações da USP
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Microfluidic system
Micromisturador
Micromixer
Microparticles
Micropartículas
PBCA
Sistema microfluídico
Link de acesso: https://www.teses.usp.br/teses/disponiveis/9/9139/tde-10102024-095208/
Resumo: Different methods of reaction control for the production of poly (butyl cyanoacrylate) microparticles have been studied, always considering pH and the monomer-to-initiator ratio. However, multiple process steps and reagents are required. Therefore, a microfluidic micro-mixer with HH geometry was employed, varying flow parameters, channel quantity, and residence time of the formulation in the system to regulate the emulsion polymerization reaction and formation of PBCA microparticles. Thus, the microparticles were synthesized via anionic emulsion polymerization (A/O) using a microfluidic system comprising a microfluidic device with an HH geometry micromixer consisting of 15-channels in LTCC, enabling synthesis in a single step. Total flow rates of 39 and 78 mL·min-1 exhibited superior results for microparticles formation. The microparticles were characterized for their morphology, demonstrating average diameter values. For the 45/55 (w/o) ratio with 19.2% (w/w) n-BCA, the average diameter was 642 nm, while for 20/80 (w/o) with 5.0% n-BCA, it was 74 µm. The microparticles exhibited spherical formation, comprising the PBCA polymer as confirmed by FTIR analyses.
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spelling Use of HH micromixer for the production of PBCA microparticles by emulsion polymerization toward cosmetic applicationUso de micromisturador HH para a produção de micropartículas de PBCA por polimerização em emulsão para aplicação cosméticaMicrofluidic systemMicromisturadorMicromixerMicroparticlesMicropartículasPBCAPBCASistema microfluídicoDifferent methods of reaction control for the production of poly (butyl cyanoacrylate) microparticles have been studied, always considering pH and the monomer-to-initiator ratio. However, multiple process steps and reagents are required. Therefore, a microfluidic micro-mixer with HH geometry was employed, varying flow parameters, channel quantity, and residence time of the formulation in the system to regulate the emulsion polymerization reaction and formation of PBCA microparticles. Thus, the microparticles were synthesized via anionic emulsion polymerization (A/O) using a microfluidic system comprising a microfluidic device with an HH geometry micromixer consisting of 15-channels in LTCC, enabling synthesis in a single step. Total flow rates of 39 and 78 mL·min-1 exhibited superior results for microparticles formation. The microparticles were characterized for their morphology, demonstrating average diameter values. For the 45/55 (w/o) ratio with 19.2% (w/w) n-BCA, the average diameter was 642 nm, while for 20/80 (w/o) with 5.0% n-BCA, it was 74 µm. The microparticles exhibited spherical formation, comprising the PBCA polymer as confirmed by FTIR analyses.Diferentes métodos de controle de reação para a produção de micropartículas de poli(butil cianoacrilato) têm sido estudados, sempre considerando o pH e a proporção do monômero e do iniciador. No entanto, são necessárias várias etapas do processo e reagentes. Com base nisso, foi utilizado um micromisturador microfluídico de geometria HH, variando parâmetros de fluxo, quantidade de canais e tempo de residência da formulação no sistema para controlar a reação de polimerização em emulsão e formação das micropartículas de PBCA. Assim, as micropartículas foram produzidas por polimerização em emulsão aniônica (A/O) usando um sistema microfluídico contendo um dispositivo microfluídico com micromisturador com geometria HH de 15 canais em LTCC, sendo realizada a síntese em uma única etapa. As vazões totais de 39 e 78 mL·min-1 apresentaram melhores resultados na formação das micropartículas. As micropartículas foram caracterizadas quanto à sua morfologia, demonstrando valores médios de diâmetro. Para a proporção 45/55 (w/o) com 19,2% (w/w) de n-BCA, o tamanho médio do diâmetro foi de 642 nm, enquanto para 20/80 (w/o) com 5,0% de n-BCA, foi de 74 µm. As micropartículas apresentaram formação esférica, consistindo do polímero PBCA, conforme confirmado pelas análises de FTIR.Biblioteca Digitais de Teses e Dissertações da USPBaby, André RolimVieira, Aline Rocha2024-09-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://www.teses.usp.br/teses/disponiveis/9/9139/tde-10102024-095208/reponame:Biblioteca Digital de Teses e Dissertações da USPinstname:Universidade de São Paulo (USP)instacron:USPLiberar o conteúdo para acesso público.info:eu-repo/semantics/openAccesseng2024-10-21T20:13:02Zoai:teses.usp.br:tde-10102024-095208Biblioteca Digital de Teses e Dissertaçõeshttp://www.teses.usp.br/PUBhttp://www.teses.usp.br/cgi-bin/mtd2br.plvirginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.bropendoar:27212024-10-21T20:13:02Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Use of HH micromixer for the production of PBCA microparticles by emulsion polymerization toward cosmetic application
Uso de micromisturador HH para a produção de micropartículas de PBCA por polimerização em emulsão para aplicação cosmética
title Use of HH micromixer for the production of PBCA microparticles by emulsion polymerization toward cosmetic application
spellingShingle Use of HH micromixer for the production of PBCA microparticles by emulsion polymerization toward cosmetic application
Vieira, Aline Rocha
Microfluidic system
Micromisturador
Micromixer
Microparticles
Micropartículas
PBCA
PBCA
Sistema microfluídico
title_short Use of HH micromixer for the production of PBCA microparticles by emulsion polymerization toward cosmetic application
title_full Use of HH micromixer for the production of PBCA microparticles by emulsion polymerization toward cosmetic application
title_fullStr Use of HH micromixer for the production of PBCA microparticles by emulsion polymerization toward cosmetic application
title_full_unstemmed Use of HH micromixer for the production of PBCA microparticles by emulsion polymerization toward cosmetic application
title_sort Use of HH micromixer for the production of PBCA microparticles by emulsion polymerization toward cosmetic application
author Vieira, Aline Rocha
author_facet Vieira, Aline Rocha
author_role author
dc.contributor.none.fl_str_mv Baby, André Rolim
dc.contributor.author.fl_str_mv Vieira, Aline Rocha
dc.subject.por.fl_str_mv Microfluidic system
Micromisturador
Micromixer
Microparticles
Micropartículas
PBCA
PBCA
Sistema microfluídico
topic Microfluidic system
Micromisturador
Micromixer
Microparticles
Micropartículas
PBCA
PBCA
Sistema microfluídico
description Different methods of reaction control for the production of poly (butyl cyanoacrylate) microparticles have been studied, always considering pH and the monomer-to-initiator ratio. However, multiple process steps and reagents are required. Therefore, a microfluidic micro-mixer with HH geometry was employed, varying flow parameters, channel quantity, and residence time of the formulation in the system to regulate the emulsion polymerization reaction and formation of PBCA microparticles. Thus, the microparticles were synthesized via anionic emulsion polymerization (A/O) using a microfluidic system comprising a microfluidic device with an HH geometry micromixer consisting of 15-channels in LTCC, enabling synthesis in a single step. Total flow rates of 39 and 78 mL·min-1 exhibited superior results for microparticles formation. The microparticles were characterized for their morphology, demonstrating average diameter values. For the 45/55 (w/o) ratio with 19.2% (w/w) n-BCA, the average diameter was 642 nm, while for 20/80 (w/o) with 5.0% n-BCA, it was 74 µm. The microparticles exhibited spherical formation, comprising the PBCA polymer as confirmed by FTIR analyses.
publishDate 2024
dc.date.none.fl_str_mv 2024-09-06
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.teses.usp.br/teses/disponiveis/9/9139/tde-10102024-095208/
url https://www.teses.usp.br/teses/disponiveis/9/9139/tde-10102024-095208/
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv
dc.rights.driver.fl_str_mv Liberar o conteúdo para acesso público.
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Liberar o conteúdo para acesso público.
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv
dc.publisher.none.fl_str_mv Biblioteca Digitais de Teses e Dissertações da USP
publisher.none.fl_str_mv Biblioteca Digitais de Teses e Dissertações da USP
dc.source.none.fl_str_mv
reponame:Biblioteca Digital de Teses e Dissertações da USP
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Biblioteca Digital de Teses e Dissertações da USP
collection Biblioteca Digital de Teses e Dissertações da USP
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)
repository.mail.fl_str_mv virginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.br
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