Implante neural controlado em malha fechada

• Ano de defesa: 2015
• Autor(a) principal: Araujo, Carlos Eduardo de
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Tecnológica Federal do Paraná; Curitiba; Brasil; Programa de Pós-Graduação em Engenharia Elétrica e Informática Industrial; UTFPR
• Palavras-chave em Português: Prótese; Dopamina; Estimulação neural; Interface cérebro-computador; Controle automático; Software - Desenvolvimento; Simulação (Computadores); Engenharia biomédica; Engenharia elétrica; Prosthesis; Dopamine; Neural stimulation; Brain-computer interfaces; Automatic control; Computer software - Development; Computer simulation; Biomedical engineering; Electric engineering; CNPQ::ENGENHARIAS::ENGENHARIA BIOMEDICA
• Link de acesso: http://repositorio.utfpr.edu.br/jspui/handle/1/1687

One of the challenges to biomedical engineers proposed by researchers in neuroscience is brain machine interaction. The nervous system communicates by interpreting electrochemical signals, and implantable circuits make decisions in order to interact with the biological environment. It is well known that Parkinson’s disease is related to a deficit of dopamine (DA). Different methods has been employed to control dopamine concentration like magnetic or electrical stimulators or drugs. In this work was automatically controlled the neurotransmitter concentration since this is not currently employed. To do that, four systems were designed and developed: deep brain stimulation (DBS), transmagnetic stimulation (TMS), Infusion Pump Control (IPC) for drug delivery, and fast scan cyclic voltammetry (FSCV) (sensing circuits which detect varying concentrations of neurotransmitters like dopamine caused by these stimulations). Some softwares also were developed for data display and analysis in synchronously with current events in the experiments. This allowed the use of infusion pumps and their flexibility is such that DBS or TMS can be used in single mode and other stimulation techniques and combinations like lights, sounds, etc. The developed system allows to control automatically the concentration of DA. The resolution of the system is around 0.4 µmol/L with time correction of concentration adjustable between 1 and 90 seconds. The system allows controlling DA concentrations between 1 and 10 µmol/L, with an error about +/- 0.8 µmol/L. Although designed to control DA concentration, the system can be used to control, the concentration of other substances. It is proposed to continue the closed loop development with FSCV and DBS (or TMS, or infusion) using parkinsonian animals models.