Uso da geléia real em cosméticos: potencial biotecnológico e análise do mercado brasileiro

• Ano de defesa: 2026
• Autor(a) principal: Silva, Nancielly Thaina Hofstatter Borges da
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Tecnológica Federal do Paraná; Ponta Grossa; Brasil; Programa de Pós-Graduação em Biotecnologia; UTFPR
• Palavras-chave em Português: Geléia real; Cosméticos; Biotecnologia; Patentes; Royal jelly; Cosmetics; Biotechnology; Patents; CNPQ::CIENCIAS BIOLOGICAS
• Link de acesso: http://repositorio.utfpr.edu.br/jspui/handle/1/40652

The cosmetics market has experienced significant growth in recent decades, driven by the increasing demand for natural, sustainable products containing bioactive compounds with proven benefits for skin health. In this context, royal jelly stands out as a promising ingredient due to its composition rich in proteins, lipids, vitamins, amino acids, and bioactive compounds, particularly 10-hydroxy-2-decenoic acid (10-HDA), which is associated with antioxidant, anti-inflammatory, wound-healing, and regenerative activities. In light of this scenario, this dissertation aimed to analyze the biotechnological potential of royal jelly for cosmetic applications through the integration of scientific evidence, technological indicators, and market information. To achieve this objective, a systematic literature review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, using the PubMed, Scopus, and Web of Science databases. Additionally, a technological prospecting study was carried out using the Espacenet database to identify innovation trends, temporal evolution of patent filings, major applicant countries, and technological fields related to the use of royal jelly in cosmetics. Furthermore, an analysis of the Brazilian market was performed based on regulatory data from the Brazilian Health Regulatory Agency (ANVISA), aiming to characterize cosmetic products containing royal jelly available in the country regarding their functional category, cosmetic form, regulatory status, and profile of the companies holding the registrations. The systematic review resulted in the inclusion of 43 studies, which highlighted the potential of royal jelly in applications mainly related to skin regeneration, wound healing, hydration, and anti-aging effects. Patent analysis demonstrated a gradual increase in technological activity over time, with a concentration of patent filings in Asian countries and a predominance of applications focused on the development of cosmetic formulations and skin care products. In turn, the market analysis revealed that, despite the broad biotechnological and technological potential of royal jelly, its presence in the Brazilian cosmetics market remains limited, being concentrated in specific niches and higher value-added products. It can be concluded that royal jelly is a promising active ingredient for the development of innovative biocosmetics, combining relevant biological properties with significant technological application potential. However, challenges related to physicochemical stability, raw material standardization, clinical validation of efficacy, and the conversion of scientific knowledge into commercially established products still limit its large-scale incorporation. Therefore, the integration of scientific research, technological development, and industrial innovation is essential to expand the use of royal jelly in the cosmetics sector.