A influência de polimorfismos genéticos ACE I/D e CK-MM A/G NCOL em atletas de futebol americano do Brasil

• Ano de defesa: 2019
• Autor(a) principal: Santoro, Gino Fellipe
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Tecnológica Federal do Paraná; Curitiba; Brasil; Programa de Pós-Graduação em Engenharia Biomédica; UTFPR
• Palavras-chave em Português: Futebol - Brasil; Futebol americano; Jogadores de futebol; Aptidão física do atleta; Genética molecular; Polimorfismo (Genética); Genética de populações; Engenharia biomédica; Soccer - Brazil; Football; Soccer players; Athletic ability; Molecular genetics; Genetic polymorphisms; Population genetics; Biomedical engineering; CNPQ::ENGENHARIAS::ENGENHARIA BIOMEDICA; Engenharia Biomédica
• Link de acesso: http://repositorio.utfpr.edu.br/jspui/handle/1/4831

In Brazil, American Football is the fastest growing sport in number of athletes and spectators. In order to achieve the best physical performance, national teams are increasingly investing in the physical preparation of athletes and the setting up of specialized and multidisciplinary technical committees. Physical performance comes from a multitude of biological and mechanical properties. These diverse phenotypes are associated through the complex interaction between the environment and the individual genetic profile. The hypothesis is that there is an inherited element that interferes with physical fitness. Among the portrayed genes that may influence this response are the angiotensin converting enzyme (ACE) and creatine kinase enzyme (MM CKMM A / G Ncol) genes. The objective is to determine the genotypic and allelic distribution profile of ACE and CK - MM genes in Brazilian American Football athletes in a team from Curitiba - PR. DNA was collected from jugal mucosa cells of 45 athletes and 37 non-athletes, all male. The genotyping of ACE I / D and CK-MM A / G Ncol polymorphisms was performed by polymerase chain reaction and analyzed by electrophoresis technique. The Chi-square test was used to compare genotype frequencies between athletes and control. The association between allele frequencies was verified through 2x2 contingency tables analyzed by Chi-square test with yates correction. For all analyzes, pvalue of ≤ 0.05 values were considered significant. ACE I / D gene genotype distribution had a significant difference between the two groups, with the athlete group having a higher representation of the DD genotype (51.1%) compared to the control group (18.9%), p-value of ≤ 0.001, a significant difference for the allele frequency of the ACE I / D gene was also observed when comparing groups; for the polymorphism of the CK-MM A / G Ncol gene we also found significant differences for both the distribution genotypic as for allelic when compared the groups. A possible genetic allelic and genotypic favoring of ACE and CK-MM A / G Ncol polymorphism is evidenced in American Football athletes in Brazil.