Influência da formação de hidroxialuminosilicatos na biodisponibilidade do alumínio
Ano de defesa: | 2010 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Química
|
Departamento: |
Química
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/10462 |
Resumo: | Solutions for parenteral nutrition may be contaminated by aluminum and silicate due to their storage in containers made of glass and due to the sterilization process (autoclave), which promotes the lixiviation of these glass constituents into the solution. The simultaneous presence of Al and silicate may lead to the formation of insoluble hydroxyaluminosilicates and the formation of particulate matter in solution. The presence of particulate matter in solutions for parenteral administration should be controlled because of the risk posed to the patients, thus, pharmacopoeias and regulatory agencies, limit the particle size to 10 Om e 25 Om in a determined volume of solution. In this study, the method of membrane filtration was used to investigate the distribution profile of particles, considering their size, in solutions containing Al (0.5 mg/L) and silicate (0.5; 1.0; 5.0; 10; and 20 mg/L), in the presence or not of 2% calcium gluconate or 1 M potassium dihydrogenphosphate (parenteral solutions presenting the highest contamination by Al and silicate). After 24 h, 1, 2, 3, and 6 months the solutions were prepared, aliquots of 2 mL were filtered in membranes of 0.1; 0.2; and 0.45 Om, and the Al and silicate were measured in the filtrates by graphite furnace atomic absorption spectrometry (GF-AAS). The interference of silicon on the Al measurement by GF-AAS was investigated, and pyrolysis and atomization temperatures were optimized. For Si measurement, chemical modifiers, such as Pd+Mg, Pd only, CaCl2 and Pd+Ca, were tested, and pyrolysis and atomization temperatures were also optimized. Particle sizes as well as their distribution as a percentage were also measured. The formation of hydroxyaluminosilicates was observed in solutions containing 0.5 mg/L Al and silicate in a concentration ≥ 10 mg/L, since for these conditions Al was not retained by the membranes. Particle size distribution confirmed this result, as the particles formed in the presence of a higher concentration of silicate (20 mg/L) were between 0.011 e 0.1 Om. Differently, particles formed in solutions with lower silicate concentration were retained by the membranes. In the presence of calcium gluconate or potassium dihydrogenphosphate it was not possible to observe the formation of hydroxyaluminosilicates. Nevertheless, it was possible to verify that the size of the particles in these solutions was not bigger than the recommended by the regulatory agencies. |
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2017-05-252017-05-252010-02-04NOREMBERG, Simone Moraes da Silva. Influence of the formation of hydroxyaluminosilicates on the biodisponibility of aluminum. 2010. 90 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2010.http://repositorio.ufsm.br/handle/1/10462Solutions for parenteral nutrition may be contaminated by aluminum and silicate due to their storage in containers made of glass and due to the sterilization process (autoclave), which promotes the lixiviation of these glass constituents into the solution. The simultaneous presence of Al and silicate may lead to the formation of insoluble hydroxyaluminosilicates and the formation of particulate matter in solution. The presence of particulate matter in solutions for parenteral administration should be controlled because of the risk posed to the patients, thus, pharmacopoeias and regulatory agencies, limit the particle size to 10 Om e 25 Om in a determined volume of solution. In this study, the method of membrane filtration was used to investigate the distribution profile of particles, considering their size, in solutions containing Al (0.5 mg/L) and silicate (0.5; 1.0; 5.0; 10; and 20 mg/L), in the presence or not of 2% calcium gluconate or 1 M potassium dihydrogenphosphate (parenteral solutions presenting the highest contamination by Al and silicate). After 24 h, 1, 2, 3, and 6 months the solutions were prepared, aliquots of 2 mL were filtered in membranes of 0.1; 0.2; and 0.45 Om, and the Al and silicate were measured in the filtrates by graphite furnace atomic absorption spectrometry (GF-AAS). The interference of silicon on the Al measurement by GF-AAS was investigated, and pyrolysis and atomization temperatures were optimized. For Si measurement, chemical modifiers, such as Pd+Mg, Pd only, CaCl2 and Pd+Ca, were tested, and pyrolysis and atomization temperatures were also optimized. Particle sizes as well as their distribution as a percentage were also measured. The formation of hydroxyaluminosilicates was observed in solutions containing 0.5 mg/L Al and silicate in a concentration ≥ 10 mg/L, since for these conditions Al was not retained by the membranes. Particle size distribution confirmed this result, as the particles formed in the presence of a higher concentration of silicate (20 mg/L) were between 0.011 e 0.1 Om. Differently, particles formed in solutions with lower silicate concentration were retained by the membranes. In the presence of calcium gluconate or potassium dihydrogenphosphate it was not possible to observe the formation of hydroxyaluminosilicates. Nevertheless, it was possible to verify that the size of the particles in these solutions was not bigger than the recommended by the regulatory agencies.Soluções para nutrição parenteral (aminoácidos, glicose, oligoelementos, entre outras) podem se apresentar contaminadas por alumínio e silicato devido à sua armazenagem em recipientes de vidro e ao processo de esterilização (autoclave) que promove a lixiviação destes componentes do vidro para a solução. A presença simultânea de Al e silicato pode levar á formação de hidroxialuminosilicatos insolúveis e a formação de partículas em solução. A presença de material particulado em soluções para administração parenteral deve ser controlada devido ao risco para os pacientes, assim, farmacopéias e órgãos de regulamentação, limitam o tamanho de partículas em 10 Om e 25 Om em um determinado volume de solução. Neste trabalho, o método de filtração em membrana foi usado para investigar o perfil de distribuição do tamanho de partículas formadas em soluções contendo alumínio (0,5 mg/L) e silício (0,5; 1,0; 5,0; 10 e 20 mg/L), na presença ou ausência de gluconato de Ca 2% ou dihidrogenofosfato de potássio 1M (soluções parenterais com os mais altos níveis de contaminação por Al e silicato). Transcorridos 24h, 1 mês, 2 meses, 3 meses ou 6 meses do preparo, alíquotas de 2 mL das soluções foram filtradas, em filtros de porosidade 0,1; 0,2 ou 0,45 Om e o alumínio e silício foram determinados no filtrado por espectrometria de absorção atômica com forno de grafite (GF-AAS). Verificou-se o efeito interferente da presença do Si na determinação de Al e escolheu-se a melhor temperatura de pirólise e atomização para ser usada. Para a melhoria e aumento do sinal na medida de Si testou-se a utilização de alguns modificadores: Pd+Mg, somente Pd, CaCl2 ou Pd+Ca e também fez-se a escolha da melhor temperatura de pirólise e atomização para a sua determinação. Ainda, foram medidos o tamanho das partículas e a porcentagem de distribuição destas em solução. Foi constatada a formação de hidroxialuminosilicatos em soluções com concentração de Al 0,5 mg/L e de Si igual ou maior a 10 mg/L, pois nessas condições o Al passa pelos filtros das membranas. A distribuição das partículas pelo tamanho confirma esse resultado, pois há a formação de partículas menores (entre 0,011 e 0,1 Om) quando o Si está presente em concentração maior (20 mg/L) quando comparadas com as formadas em 1 mg/L ou sem adição deste. Em meio gluconato de Ca 2% e dihidrogenofosfato de potássio 1M não foi possível identificar a formação de hidroxialuminosilicatos, através dos métodos utilizados. Entretanto, pode-se verificar que não há a formação de partículas maiores que as recomendadas pelos órgãos de regulamentação para estas soluções.Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em QuímicaUFSMBRQuímicaAlumínioSilícioHidroxialuminosilicatosSoluções de nutrição parenteralAluminumSiliconHydroxyaluminosilicatesSolutions for parenteral nutritionCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICAInfluência da formação de hidroxialuminosilicatos na biodisponibilidade do alumínioInfluence of the formation of hydroxyaluminosilicates on the biodisponibility of aluminuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisNascimento, Denise Bohrer dohttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4798557Z7Lang, Ernesto Schulzhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4786424E6Schetinger, Maria Rosa Chitolinahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4221886E0Noremberg, Simone Moraes da Silva1006000000004005003003005001c5af0ad-15cf-4a7e-9b25-b8b6b1363ae66681f3ac-bb8c-45ac-88a4-6bafa8420ffee3a53c49-da59-406c-adde-2bac147819cf93acb9e6-39fa-412c-84a4-a90a4863b53einfo:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALNOREMBERG, SIMONE MORAES DA SILVA.pdfapplication/pdf2932424http://repositorio.ufsm.br/bitstream/1/10462/1/NOREMBERG%2c%20SIMONE%20MORAES%20DA%20SILVA.pdf007f94303f98eb09370c072d33bd3d4bMD51TEXTNOREMBERG, SIMONE MORAES DA SILVA.pdf.txtNOREMBERG, SIMONE MORAES DA SILVA.pdf.txtExtracted texttext/plain144409http://repositorio.ufsm.br/bitstream/1/10462/2/NOREMBERG%2c%20SIMONE%20MORAES%20DA%20SILVA.pdf.txt430197d578a517b443dacda32c7859f9MD52THUMBNAILNOREMBERG, SIMONE MORAES DA SILVA.pdf.jpgNOREMBERG, SIMONE MORAES DA SILVA.pdf.jpgIM Thumbnailimage/jpeg4969http://repositorio.ufsm.br/bitstream/1/10462/3/NOREMBERG%2c%20SIMONE%20MORAES%20DA%20SILVA.pdf.jpgce247d36e5ebedf268d6ab38cfaa0da9MD531/104622017-07-25 12:05:01.728oai:repositorio.ufsm.br:1/10462Repositório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestopendoar:39132017-07-25T15:05:01Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Influência da formação de hidroxialuminosilicatos na biodisponibilidade do alumínio |
dc.title.alternative.eng.fl_str_mv |
Influence of the formation of hydroxyaluminosilicates on the biodisponibility of aluminum |
title |
Influência da formação de hidroxialuminosilicatos na biodisponibilidade do alumínio |
spellingShingle |
Influência da formação de hidroxialuminosilicatos na biodisponibilidade do alumínio Noremberg, Simone Moraes da Silva Alumínio Silício Hidroxialuminosilicatos Soluções de nutrição parenteral Aluminum Silicon Hydroxyaluminosilicates Solutions for parenteral nutrition CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Influência da formação de hidroxialuminosilicatos na biodisponibilidade do alumínio |
title_full |
Influência da formação de hidroxialuminosilicatos na biodisponibilidade do alumínio |
title_fullStr |
Influência da formação de hidroxialuminosilicatos na biodisponibilidade do alumínio |
title_full_unstemmed |
Influência da formação de hidroxialuminosilicatos na biodisponibilidade do alumínio |
title_sort |
Influência da formação de hidroxialuminosilicatos na biodisponibilidade do alumínio |
author |
Noremberg, Simone Moraes da Silva |
author_facet |
Noremberg, Simone Moraes da Silva |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Nascimento, Denise Bohrer do |
dc.contributor.advisor1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4798557Z7 |
dc.contributor.referee1.fl_str_mv |
Lang, Ernesto Schulz |
dc.contributor.referee1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4786424E6 |
dc.contributor.referee2.fl_str_mv |
Schetinger, Maria Rosa Chitolina |
dc.contributor.authorLattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4221886E0 |
dc.contributor.author.fl_str_mv |
Noremberg, Simone Moraes da Silva |
contributor_str_mv |
Nascimento, Denise Bohrer do Lang, Ernesto Schulz Schetinger, Maria Rosa Chitolina |
dc.subject.por.fl_str_mv |
Alumínio Silício Hidroxialuminosilicatos Soluções de nutrição parenteral |
topic |
Alumínio Silício Hidroxialuminosilicatos Soluções de nutrição parenteral Aluminum Silicon Hydroxyaluminosilicates Solutions for parenteral nutrition CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
Aluminum Silicon Hydroxyaluminosilicates Solutions for parenteral nutrition |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
Solutions for parenteral nutrition may be contaminated by aluminum and silicate due to their storage in containers made of glass and due to the sterilization process (autoclave), which promotes the lixiviation of these glass constituents into the solution. The simultaneous presence of Al and silicate may lead to the formation of insoluble hydroxyaluminosilicates and the formation of particulate matter in solution. The presence of particulate matter in solutions for parenteral administration should be controlled because of the risk posed to the patients, thus, pharmacopoeias and regulatory agencies, limit the particle size to 10 Om e 25 Om in a determined volume of solution. In this study, the method of membrane filtration was used to investigate the distribution profile of particles, considering their size, in solutions containing Al (0.5 mg/L) and silicate (0.5; 1.0; 5.0; 10; and 20 mg/L), in the presence or not of 2% calcium gluconate or 1 M potassium dihydrogenphosphate (parenteral solutions presenting the highest contamination by Al and silicate). After 24 h, 1, 2, 3, and 6 months the solutions were prepared, aliquots of 2 mL were filtered in membranes of 0.1; 0.2; and 0.45 Om, and the Al and silicate were measured in the filtrates by graphite furnace atomic absorption spectrometry (GF-AAS). The interference of silicon on the Al measurement by GF-AAS was investigated, and pyrolysis and atomization temperatures were optimized. For Si measurement, chemical modifiers, such as Pd+Mg, Pd only, CaCl2 and Pd+Ca, were tested, and pyrolysis and atomization temperatures were also optimized. Particle sizes as well as their distribution as a percentage were also measured. The formation of hydroxyaluminosilicates was observed in solutions containing 0.5 mg/L Al and silicate in a concentration ≥ 10 mg/L, since for these conditions Al was not retained by the membranes. Particle size distribution confirmed this result, as the particles formed in the presence of a higher concentration of silicate (20 mg/L) were between 0.011 e 0.1 Om. Differently, particles formed in solutions with lower silicate concentration were retained by the membranes. In the presence of calcium gluconate or potassium dihydrogenphosphate it was not possible to observe the formation of hydroxyaluminosilicates. Nevertheless, it was possible to verify that the size of the particles in these solutions was not bigger than the recommended by the regulatory agencies. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-02-04 |
dc.date.accessioned.fl_str_mv |
2017-05-25 |
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2017-05-25 |
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NOREMBERG, Simone Moraes da Silva. Influence of the formation of hydroxyaluminosilicates on the biodisponibility of aluminum. 2010. 90 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2010. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/10462 |
identifier_str_mv |
NOREMBERG, Simone Moraes da Silva. Influence of the formation of hydroxyaluminosilicates on the biodisponibility of aluminum. 2010. 90 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2010. |
url |
http://repositorio.ufsm.br/handle/1/10462 |
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