Hidroxialuminosilicatos e a biodisponibilidade do alumínio: avaliação in vivo
Ano de defesa: | 2012 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Química
|
Departamento: |
Química
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/4243 |
Resumo: | Aluminium (Al) and silicon (Si) are contaminants found in substances used in the parenteral nutrition (PN). Because of its large volume, nutrition and infusion solutions are pharmaceutical products parenterally administered, which present higher risks of adverse effects when contaminated. Insoluble and biologically inert species of hydroxyaluminosilicates (HAS) may be formed in solutions containing Al and Si when pH > 4.5. This chemical interaction is considered of great interest in biology because of its possible role in detoxification or protection against metal toxicity. In this study the Al bioavailability was investigated in the presence of Si and some PN components in vivo. Al and Si body distribution in Wistar rats was analyzed after 60 administrations of Al 0.5 mg/kg/day and/or Si 2 mg/kg/day in the presence or absence of calcium gluconate or potassium dihydrogenphosphate in concentrations similar to those used in the PN solutions. δ -Aminolevulinic acid dehydratase enzyme activity and tiobarbituric acid reactive species (TBARS) content was also evaluated in animal tissues. Tissue digestion methods were optimized for the determination of both Al and Si in the same samples by Graphite Furnace Atomic Absorption Spectrometry (GFAAS). Better Al and Si recoveries in animal tissue samples occurred after dissolution with tetramethylammonium hydroxide (TMAH) using Si 15 mg/L as modifier for Al determination and Pd 2 g/L for Si. Before the measurements, graphite furnace was coated with Zr following a specific heating program. Al accumulated in all tissues, especially in the liver, kidneys, bones and blood. Si decreased Al accumulation, this effect was less pronounced in the presence of PN components though. Si tissue accumulation was also observed, mainly when administered together with phosphate. Although Al was deposited in the tissues, pronounced toxicity effects were not observed. Increase in lipidic peroxidation was observed in a few tissues. When δ-ALA-D activity was altered, it was increased in Al treated groups, mainly in Ca gluconate treatment. As a conclusion, Si did not decrease Al deposition and therefore the metal biodisponibility amidst the NP components. |
id |
UFSM_54432b18d7653f9e048f38ff04ad06ea |
---|---|
oai_identifier_str |
oai:repositorio.ufsm.br:1/4243 |
network_acronym_str |
UFSM |
network_name_str |
Biblioteca Digital de Teses e Dissertações do UFSM |
repository_id_str |
|
spelling |
2017-05-252017-05-252012-12-10KUNZ, Simone Noremberg. Hydroxyaluminosilicates and the biodisponibility of aluminum: evaluation in vivo. 2012. 148 f. Tese (Doutorado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2012.http://repositorio.ufsm.br/handle/1/4243Aluminium (Al) and silicon (Si) are contaminants found in substances used in the parenteral nutrition (PN). Because of its large volume, nutrition and infusion solutions are pharmaceutical products parenterally administered, which present higher risks of adverse effects when contaminated. Insoluble and biologically inert species of hydroxyaluminosilicates (HAS) may be formed in solutions containing Al and Si when pH > 4.5. This chemical interaction is considered of great interest in biology because of its possible role in detoxification or protection against metal toxicity. In this study the Al bioavailability was investigated in the presence of Si and some PN components in vivo. Al and Si body distribution in Wistar rats was analyzed after 60 administrations of Al 0.5 mg/kg/day and/or Si 2 mg/kg/day in the presence or absence of calcium gluconate or potassium dihydrogenphosphate in concentrations similar to those used in the PN solutions. δ -Aminolevulinic acid dehydratase enzyme activity and tiobarbituric acid reactive species (TBARS) content was also evaluated in animal tissues. Tissue digestion methods were optimized for the determination of both Al and Si in the same samples by Graphite Furnace Atomic Absorption Spectrometry (GFAAS). Better Al and Si recoveries in animal tissue samples occurred after dissolution with tetramethylammonium hydroxide (TMAH) using Si 15 mg/L as modifier for Al determination and Pd 2 g/L for Si. Before the measurements, graphite furnace was coated with Zr following a specific heating program. Al accumulated in all tissues, especially in the liver, kidneys, bones and blood. Si decreased Al accumulation, this effect was less pronounced in the presence of PN components though. Si tissue accumulation was also observed, mainly when administered together with phosphate. Although Al was deposited in the tissues, pronounced toxicity effects were not observed. Increase in lipidic peroxidation was observed in a few tissues. When δ-ALA-D activity was altered, it was increased in Al treated groups, mainly in Ca gluconate treatment. As a conclusion, Si did not decrease Al deposition and therefore the metal biodisponibility amidst the NP components.O alumínio (Al) e o silício (Si) são contaminantes encontrados em substâncias usadas na nutrição parenteral (NP). Devido ao seu grande volume, soluções de nutrição e de infusão são os fármacos, administrados por via parenteral, que apresentam mais efeitos adversos se contiverem contaminantes. Hidroxialuminosilicatos (HAS) insolúveis e biologicamente inertes podem se formar em soluções contendo Al e Si quando o pH > 4,5. Esta interação química é considerada de grande interesse no campo biológico devido ao seu possível papel na desintoxicação ou proteção contra a toxicidade do metal. Neste trabalho, foi investigada a biodisponibilidade do Al na presença do Si e de alguns componentes da NP in vivo. Primeiramente otimizou-se os métodos de abertura de tecido biológico para análise de Al e Si coexistentes nas amostras por espectromentria de absorção atômica com forno de grafite. Foi analisada a distribuição do Al e Si no organismo de ratos Wistar após 60 administrações de 0,5 mg/kg/dia de Al e/ou 2 mg/kg/dia de Si na presença ou não de gluconato de cálcio ou dihidrogenofosfato de potássio em concentrações semelhantes as usadas nas soluções de NP. Foi também avaliada a atividade da enzima δ-aminolevulinato desidratase (δ-ALA-D) e espécies reativas ao ácido tiobarbitúrico (TBARS) nos tecidos dos animais. As melhores recuperações de Al e Si nas amostras de tecido animal ocorreram após dissolução com hidróxido de tetrametilamônio (HTMA) utilizando Si 15 mg/L como modificador para determinação de Al e Pd 2 g/L para Si. Foi necessário o recobrimento do forno com Zr para a medida das amostras dissolvidas com HTMA. O Al se acumulou em todos os tecidos, principalmente no fígado, rim, osso e sangue. O Si diminuiu o acúmulo do metal nos tecidos, mas esse efeito é menos pronunciado em meio aos componentes da NP. Foi observado o depósito de Si nos tecidos, principalmente no tratamento com fosfato. Apesar do Al ter se depositado nos tecidos, não foram observados efeitos pronunciados de toxicidade. Em poucos tecidos observou-se aumento na peroxidação lipídica nos tratamentos e a atividade da enzima δ-ALA-D, quando alterada, aparece aumentada nos grupos tratados com Al, principalmente no tratamento com gluconato de Ca. Como conclusão, o Si não diminui a deposição do Al e, portanto, a biodisponibilidade do metal em meio aos componentes da NP.application/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em QuímicaUFSMBRQuímicaAlumínioSilícioHidroxialuminosilicatosSoluções de nutrição parenteralδ-ALA-DTBARSAluminiumSiliconHydroxyaluminosilicatesSolutions for parenteral nutritionCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICAHidroxialuminosilicatos e a biodisponibilidade do alumínio: avaliação in vivoHydroxyaluminosilicates and the biodisponibility of aluminum: evaluation in vivoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisNascimento, Denise Bohrer dohttp://lattes.cnpq.br/9817093263802769Santos, Francielli Weberhttp://lattes.cnpq.br/1934452177482144Savegnago, Luciellihttp://lattes.cnpq.br/1480751214999787http://lattes.cnpq.br/0979416016892842Kunz, Simone Noremberg1006000000004005003003003001c5af0ad-15cf-4a7e-9b25-b8b6b1363ae6ad728a4e-21cd-4584-8496-77f2cebab966c6535786-ba5f-48c8-a150-789fe5ce6907035e47ec-538a-4917-9af7-bab98608a1adinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALNOREMBERG, SIMONE MORAES DA SILVA.pdfapplication/pdf1088642http://repositorio.ufsm.br/bitstream/1/4243/1/NOREMBERG%2c%20SIMONE%20MORAES%20DA%20SILVA.pdf3fd4355587aa5938517db61741a7e653MD51TEXTNOREMBERG, SIMONE MORAES DA SILVA.pdf.txtNOREMBERG, SIMONE MORAES DA SILVA.pdf.txtExtracted texttext/plain259185http://repositorio.ufsm.br/bitstream/1/4243/2/NOREMBERG%2c%20SIMONE%20MORAES%20DA%20SILVA.pdf.txt3808d6e71b25951be3998611e0de752dMD52THUMBNAILNOREMBERG, SIMONE MORAES DA SILVA.pdf.jpgNOREMBERG, SIMONE MORAES DA SILVA.pdf.jpgIM Thumbnailimage/jpeg5093http://repositorio.ufsm.br/bitstream/1/4243/3/NOREMBERG%2c%20SIMONE%20MORAES%20DA%20SILVA.pdf.jpg74485394f1e74d9c8fb83f18b816a7b0MD531/42432021-11-22 10:01:40.817oai:repositorio.ufsm.br:1/4243Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2021-11-22T13:01:40Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Hidroxialuminosilicatos e a biodisponibilidade do alumínio: avaliação in vivo |
dc.title.alternative.eng.fl_str_mv |
Hydroxyaluminosilicates and the biodisponibility of aluminum: evaluation in vivo |
title |
Hidroxialuminosilicatos e a biodisponibilidade do alumínio: avaliação in vivo |
spellingShingle |
Hidroxialuminosilicatos e a biodisponibilidade do alumínio: avaliação in vivo Kunz, Simone Noremberg Alumínio Silício Hidroxialuminosilicatos Soluções de nutrição parenteral δ-ALA-D TBARS Aluminium Silicon Hydroxyaluminosilicates Solutions for parenteral nutrition CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Hidroxialuminosilicatos e a biodisponibilidade do alumínio: avaliação in vivo |
title_full |
Hidroxialuminosilicatos e a biodisponibilidade do alumínio: avaliação in vivo |
title_fullStr |
Hidroxialuminosilicatos e a biodisponibilidade do alumínio: avaliação in vivo |
title_full_unstemmed |
Hidroxialuminosilicatos e a biodisponibilidade do alumínio: avaliação in vivo |
title_sort |
Hidroxialuminosilicatos e a biodisponibilidade do alumínio: avaliação in vivo |
author |
Kunz, Simone Noremberg |
author_facet |
Kunz, Simone Noremberg |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Nascimento, Denise Bohrer do |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9817093263802769 |
dc.contributor.referee1.fl_str_mv |
Santos, Francielli Weber |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/1934452177482144 |
dc.contributor.referee2.fl_str_mv |
Savegnago, Lucielli |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/1480751214999787 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0979416016892842 |
dc.contributor.author.fl_str_mv |
Kunz, Simone Noremberg |
contributor_str_mv |
Nascimento, Denise Bohrer do Santos, Francielli Weber Savegnago, Lucielli |
dc.subject.por.fl_str_mv |
Alumínio Silício Hidroxialuminosilicatos Soluções de nutrição parenteral δ-ALA-D TBARS |
topic |
Alumínio Silício Hidroxialuminosilicatos Soluções de nutrição parenteral δ-ALA-D TBARS Aluminium Silicon Hydroxyaluminosilicates Solutions for parenteral nutrition CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
Aluminium Silicon Hydroxyaluminosilicates Solutions for parenteral nutrition |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
Aluminium (Al) and silicon (Si) are contaminants found in substances used in the parenteral nutrition (PN). Because of its large volume, nutrition and infusion solutions are pharmaceutical products parenterally administered, which present higher risks of adverse effects when contaminated. Insoluble and biologically inert species of hydroxyaluminosilicates (HAS) may be formed in solutions containing Al and Si when pH > 4.5. This chemical interaction is considered of great interest in biology because of its possible role in detoxification or protection against metal toxicity. In this study the Al bioavailability was investigated in the presence of Si and some PN components in vivo. Al and Si body distribution in Wistar rats was analyzed after 60 administrations of Al 0.5 mg/kg/day and/or Si 2 mg/kg/day in the presence or absence of calcium gluconate or potassium dihydrogenphosphate in concentrations similar to those used in the PN solutions. δ -Aminolevulinic acid dehydratase enzyme activity and tiobarbituric acid reactive species (TBARS) content was also evaluated in animal tissues. Tissue digestion methods were optimized for the determination of both Al and Si in the same samples by Graphite Furnace Atomic Absorption Spectrometry (GFAAS). Better Al and Si recoveries in animal tissue samples occurred after dissolution with tetramethylammonium hydroxide (TMAH) using Si 15 mg/L as modifier for Al determination and Pd 2 g/L for Si. Before the measurements, graphite furnace was coated with Zr following a specific heating program. Al accumulated in all tissues, especially in the liver, kidneys, bones and blood. Si decreased Al accumulation, this effect was less pronounced in the presence of PN components though. Si tissue accumulation was also observed, mainly when administered together with phosphate. Although Al was deposited in the tissues, pronounced toxicity effects were not observed. Increase in lipidic peroxidation was observed in a few tissues. When δ-ALA-D activity was altered, it was increased in Al treated groups, mainly in Ca gluconate treatment. As a conclusion, Si did not decrease Al deposition and therefore the metal biodisponibility amidst the NP components. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-12-10 |
dc.date.accessioned.fl_str_mv |
2017-05-25 |
dc.date.available.fl_str_mv |
2017-05-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
KUNZ, Simone Noremberg. Hydroxyaluminosilicates and the biodisponibility of aluminum: evaluation in vivo. 2012. 148 f. Tese (Doutorado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/4243 |
identifier_str_mv |
KUNZ, Simone Noremberg. Hydroxyaluminosilicates and the biodisponibility of aluminum: evaluation in vivo. 2012. 148 f. Tese (Doutorado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2012. |
url |
http://repositorio.ufsm.br/handle/1/4243 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
100600000000 |
dc.relation.confidence.fl_str_mv |
400 500 300 300 300 |
dc.relation.authority.fl_str_mv |
1c5af0ad-15cf-4a7e-9b25-b8b6b1363ae6 ad728a4e-21cd-4584-8496-77f2cebab966 c6535786-ba5f-48c8-a150-789fe5ce6907 035e47ec-538a-4917-9af7-bab98608a1ad |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Química |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
BR |
dc.publisher.department.fl_str_mv |
Química |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações do UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Biblioteca Digital de Teses e Dissertações do UFSM |
collection |
Biblioteca Digital de Teses e Dissertações do UFSM |
bitstream.url.fl_str_mv |
http://repositorio.ufsm.br/bitstream/1/4243/1/NOREMBERG%2c%20SIMONE%20MORAES%20DA%20SILVA.pdf http://repositorio.ufsm.br/bitstream/1/4243/2/NOREMBERG%2c%20SIMONE%20MORAES%20DA%20SILVA.pdf.txt http://repositorio.ufsm.br/bitstream/1/4243/3/NOREMBERG%2c%20SIMONE%20MORAES%20DA%20SILVA.pdf.jpg |
bitstream.checksum.fl_str_mv |
3fd4355587aa5938517db61741a7e653 3808d6e71b25951be3998611e0de752d 74485394f1e74d9c8fb83f18b816a7b0 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
_version_ |
1793239972876124160 |