Efeito do ultrassom pulsado de baixa intensidade sobre o infiltrado inflamat??rio presente no m??sculo esquel??tico ap??s les??o aguda
Ano de defesa: | 2015 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Nove de Julho
|
Programa de Pós-Graduação: |
Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o
|
Departamento: |
Sa??de
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://bibliotecatede.uninove.br/handle/tede/1803 |
Resumo: | Muscle lesions although more common in athletes also affects sedentary people, leading to partial or total removal of the individual from their daily activities. The muscle repair process comprises interdependent phases orchestrated by immune cells that invade the tissue behind the injury occurrence. Delays or enhancements at different stages can lead to chronic inflammation cases or fibrosis, reinforcing the search for an alternative treatment. The therapeutic ultrasound (US) is widely used to treat muscle injuries, but lack scientific evidence to explain its mechanism of action. This study aimed aims to elucidate the role of US in the inflammatory infiltrate cells presentes on the muscle tissue behind acute injury. For this purpose, 45 Wistar rats will were used, separated into 3 groups (5 animals in the control group, 20 animals suffer injury and will not receive treatment and 20 animals suffer injury and will be treat with US). The adopted procedure is the cryoinjury lesion consisting of two bat applications of cooled in liquid nitrogen directly into the in tibialis anterior (TA) muscle. The US treatment and these groups will be evaluate after 1, 2, 3 and 7 days. The US treatment (stationary mode, pulse 1: 4, with a frequency of 1 MHz and intensity of 0.4 W / cm2) was performed daily for 3 minutes. At the end of the study, the animals were euthanized with an anesthetic overdosis and the TA muscles were removed for neutrophil infiltration analysis and the different phenotypes of macrophages during muscle remodeling by immunostaining (positive for CD68, CD80, CD163, CD206 and elastase). The images were analyzed and quantified using the Image J software (National Institute of Health - NIH, USA). Statistical analysis of data was performed according to evaluating the distribution of the same by & Kolmogorov Smirnov test. Treatment with US generated in the damaged areas of the treated muscles, reduction in the number of neutrophils (elastase +) during the periods 1 and 2 days, an increase of M1 macrophages (CD80 +) in one day period and reducing them in periods of 2, 3 and 7 days. It was also noted when comparing the injured muscles untreated, the US generated reduced profile macrophages M2a (CD206 +) on day 2 and increased this phenotype cells present on day 3. The labeling of total macrophages (CD68 +) uS-treated animals was lower than that present in untreated animals on days 2, 3 and 7. There was no difference in other temporal comparisons. As continuity and the intensity of cells presence with pro or anti inflammatory action can leading to chronic inflammation or fibrosis cases, attesting the US's ability can modulate the occurrence of these cells is an important step in understanding the therapeutic potential of this resource in the treatment of muscle injuries. |
id |
NOVE_cac9ed6b4b69f89d1d7c73447f752c4f |
---|---|
oai_identifier_str |
oai:localhost:tede/1803 |
network_acronym_str |
NOVE |
network_name_str |
Biblioteca Digital de Teses e Dissertações da Uninove |
repository_id_str |
|
spelling |
Fernandes, Kristianne Porta SantosFernandes, Kristianne Porta SantosFerrari, Raquel Agnelli MesquitaDurigan, Rita de C??ssia Marquetihttp://lattes.cnpq.br/6755212068254133Silva Junior, Evaldo Moreira da2018-06-19T13:32:21Z2015-12-10Silva Junior, Evaldo Moreira da. Efeito do ultrassom pulsado de baixa intensidade sobre o infiltrado inflamat??rio presente no m??sculo esquel??tico ap??s les??o aguda. 2015. 62 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo.http://bibliotecatede.uninove.br/handle/tede/1803Muscle lesions although more common in athletes also affects sedentary people, leading to partial or total removal of the individual from their daily activities. The muscle repair process comprises interdependent phases orchestrated by immune cells that invade the tissue behind the injury occurrence. Delays or enhancements at different stages can lead to chronic inflammation cases or fibrosis, reinforcing the search for an alternative treatment. The therapeutic ultrasound (US) is widely used to treat muscle injuries, but lack scientific evidence to explain its mechanism of action. This study aimed aims to elucidate the role of US in the inflammatory infiltrate cells presentes on the muscle tissue behind acute injury. For this purpose, 45 Wistar rats will were used, separated into 3 groups (5 animals in the control group, 20 animals suffer injury and will not receive treatment and 20 animals suffer injury and will be treat with US). The adopted procedure is the cryoinjury lesion consisting of two bat applications of cooled in liquid nitrogen directly into the in tibialis anterior (TA) muscle. The US treatment and these groups will be evaluate after 1, 2, 3 and 7 days. The US treatment (stationary mode, pulse 1: 4, with a frequency of 1 MHz and intensity of 0.4 W / cm2) was performed daily for 3 minutes. At the end of the study, the animals were euthanized with an anesthetic overdosis and the TA muscles were removed for neutrophil infiltration analysis and the different phenotypes of macrophages during muscle remodeling by immunostaining (positive for CD68, CD80, CD163, CD206 and elastase). The images were analyzed and quantified using the Image J software (National Institute of Health - NIH, USA). Statistical analysis of data was performed according to evaluating the distribution of the same by & Kolmogorov Smirnov test. Treatment with US generated in the damaged areas of the treated muscles, reduction in the number of neutrophils (elastase +) during the periods 1 and 2 days, an increase of M1 macrophages (CD80 +) in one day period and reducing them in periods of 2, 3 and 7 days. It was also noted when comparing the injured muscles untreated, the US generated reduced profile macrophages M2a (CD206 +) on day 2 and increased this phenotype cells present on day 3. The labeling of total macrophages (CD68 +) uS-treated animals was lower than that present in untreated animals on days 2, 3 and 7. There was no difference in other temporal comparisons. As continuity and the intensity of cells presence with pro or anti inflammatory action can leading to chronic inflammation or fibrosis cases, attesting the US's ability can modulate the occurrence of these cells is an important step in understanding the therapeutic potential of this resource in the treatment of muscle injuries.As les??es musculares embora mais comuns em atletas, atingem tamb??m os n??o praticantes de atividades f??sica, levando o indiv??duo ao afastamento de suas atividades di??rias. O reparo muscular compreende fases interdependentes orquestradas pelas c??lulas imunes que invadem o tecido logo ap??s a ocorr??ncia da les??o. O ultrassom (US) terap??utico ?? vastamente utilizado no tratamento de les??es musculares, por??m faltam evid??ncias cient??ficas que expliquem seu mecanismo de a????o. Este trabalho visou elucidar o papel do US sobre as c??lulas componentes do infiltrado inflamat??rio presente no tecido muscular ap??s les??o aguda. Para tanto, foram utilizados 45 ratos Wistar, separados em 3 grupos (5 animais no grupo controle, 20 animais sofreram les??o e n??o receberam tratamento e 20 animais sofreram les??o e foram tratados com US). O procedimento de les??o adotado foi a crioles??o com duas aplica????es de bast??o resfriado em nitrog??nio l??quido diretamente no m??sculo tibial anterior (TA). O US (modo estacion??rio, pulsado 1:4, com frequ??ncia de 1 MHz e intensidade de 0,4 W/cm2) foi aplicado diariamente por 3 minutos no respectivo m??sculo. Ao t??rmino dos per??odos experimentais (1, 2, 3 e 7 dias), os m??sculos TA foram analisados quanto a presen??a de neutr??filos e dos diferentes fen??tipos de macr??fagos por meio de imunomarca????o (positividade para elastase, CD68, CD80 e CD206). As imagens foram analisadas e quantificadas por meio do software Image J (NIH, EUA). A an??lise estat??stica dos dados foi realizada de acordo com a avalia????o da distribui????o dos mesmos pelo teste de Kolmogorov & Smirnov. O tratamento com US gerou, nas ??reas lesionadas dos m??sculos tratados, redu????o no n??mero de neutr??filos (elastase+) nos per??odos de 1 e 2 dias, aumento de macr??fagos M1 (CD80+) no per??odo de 1 dia e redu????o destes nos per??odos de 2, 3 e 7 dias. Tamb??m foi poss??vel observar quando da compara????o com os m??sculos lesionados n??o tratados, que o US gerou diminui????o de macr??fagos de perfil M2a (CD206+) no dia 2 e aumento da presen??a de c??lulas deste fen??tipo no dia 3. A marca????o de macr??fagos totais (CD68+) nos animais tratados com US foi menor do que a presente nos animais n??o tratados nos dias 2, 3 e 7. N??o houve diferen??a nas demais compara????es temporais. Como continuidade e a intensidade da presen??a de c??lulas com a????o pr?? ou anti inflamat??ria pode levar a quadros de inflama????o cr??nica ou de fibrose, a comprova????o da capacidade do US em modular a ocorr??ncia destas c??lulas representa uma importante passo para a compreens??o do potencial terap??utico deste recurso no tratamento de les??es musculares.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-06-19T13:32:21Z No. of bitstreams: 1 Evaldo Moreira da Silva Junior.pdf: 1681061 bytes, checksum: 3c8938d092baff83e502672b6d6a1b69 (MD5)Made available in DSpace on 2018-06-19T13:32:21Z (GMT). No. of bitstreams: 1 Evaldo Moreira da Silva Junior.pdf: 1681061 bytes, checksum: 3c8938d092baff83e502672b6d6a1b69 (MD5) Previous issue date: 2015-12-10application/pdfporUniversidade Nove de JulhoPrograma de P??s-Gradua????o em Ci??ncias da Reabilita????oUNINOVEBrasilSa??deultrassomreparo muscularc??lulas inflamat??riasmacr??fagosultrasoundmuscle repairinflammatory cellsmacrophagesCIENCIAS DA SAUDEEfeito do ultrassom pulsado de baixa intensidade sobre o infiltrado inflamat??rio presente no m??sculo esquel??tico ap??s les??o agudaEffect of low intensity pulsed ultrasound on the inflammatory infiltrate present in skeletal muscle after acute injuryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALEvaldo Moreira da Silva Junior.pdfEvaldo Moreira da Silva Junior.pdfapplication/pdf1681061http://localhost:8080/tede/bitstream/tede/1803/2/Evaldo+Moreira+da+Silva+Junior.pdf3c8938d092baff83e502672b6d6a1b69MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/1803/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/18032018-06-19 10:32:22.003oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2018-06-19T13:32:22Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Efeito do ultrassom pulsado de baixa intensidade sobre o infiltrado inflamat??rio presente no m??sculo esquel??tico ap??s les??o aguda |
dc.title.alternative.eng.fl_str_mv |
Effect of low intensity pulsed ultrasound on the inflammatory infiltrate present in skeletal muscle after acute injury |
title |
Efeito do ultrassom pulsado de baixa intensidade sobre o infiltrado inflamat??rio presente no m??sculo esquel??tico ap??s les??o aguda |
spellingShingle |
Efeito do ultrassom pulsado de baixa intensidade sobre o infiltrado inflamat??rio presente no m??sculo esquel??tico ap??s les??o aguda Silva Junior, Evaldo Moreira da ultrassom reparo muscular c??lulas inflamat??rias macr??fagos ultrasound muscle repair inflammatory cells macrophages CIENCIAS DA SAUDE |
title_short |
Efeito do ultrassom pulsado de baixa intensidade sobre o infiltrado inflamat??rio presente no m??sculo esquel??tico ap??s les??o aguda |
title_full |
Efeito do ultrassom pulsado de baixa intensidade sobre o infiltrado inflamat??rio presente no m??sculo esquel??tico ap??s les??o aguda |
title_fullStr |
Efeito do ultrassom pulsado de baixa intensidade sobre o infiltrado inflamat??rio presente no m??sculo esquel??tico ap??s les??o aguda |
title_full_unstemmed |
Efeito do ultrassom pulsado de baixa intensidade sobre o infiltrado inflamat??rio presente no m??sculo esquel??tico ap??s les??o aguda |
title_sort |
Efeito do ultrassom pulsado de baixa intensidade sobre o infiltrado inflamat??rio presente no m??sculo esquel??tico ap??s les??o aguda |
author |
Silva Junior, Evaldo Moreira da |
author_facet |
Silva Junior, Evaldo Moreira da |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Fernandes, Kristianne Porta Santos |
dc.contributor.referee1.fl_str_mv |
Fernandes, Kristianne Porta Santos |
dc.contributor.referee2.fl_str_mv |
Ferrari, Raquel Agnelli Mesquita |
dc.contributor.referee3.fl_str_mv |
Durigan, Rita de C??ssia Marqueti |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6755212068254133 |
dc.contributor.author.fl_str_mv |
Silva Junior, Evaldo Moreira da |
contributor_str_mv |
Fernandes, Kristianne Porta Santos Fernandes, Kristianne Porta Santos Ferrari, Raquel Agnelli Mesquita Durigan, Rita de C??ssia Marqueti |
dc.subject.por.fl_str_mv |
ultrassom reparo muscular c??lulas inflamat??rias macr??fagos |
topic |
ultrassom reparo muscular c??lulas inflamat??rias macr??fagos ultrasound muscle repair inflammatory cells macrophages CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
ultrasound muscle repair inflammatory cells macrophages |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Muscle lesions although more common in athletes also affects sedentary people, leading to partial or total removal of the individual from their daily activities. The muscle repair process comprises interdependent phases orchestrated by immune cells that invade the tissue behind the injury occurrence. Delays or enhancements at different stages can lead to chronic inflammation cases or fibrosis, reinforcing the search for an alternative treatment. The therapeutic ultrasound (US) is widely used to treat muscle injuries, but lack scientific evidence to explain its mechanism of action. This study aimed aims to elucidate the role of US in the inflammatory infiltrate cells presentes on the muscle tissue behind acute injury. For this purpose, 45 Wistar rats will were used, separated into 3 groups (5 animals in the control group, 20 animals suffer injury and will not receive treatment and 20 animals suffer injury and will be treat with US). The adopted procedure is the cryoinjury lesion consisting of two bat applications of cooled in liquid nitrogen directly into the in tibialis anterior (TA) muscle. The US treatment and these groups will be evaluate after 1, 2, 3 and 7 days. The US treatment (stationary mode, pulse 1: 4, with a frequency of 1 MHz and intensity of 0.4 W / cm2) was performed daily for 3 minutes. At the end of the study, the animals were euthanized with an anesthetic overdosis and the TA muscles were removed for neutrophil infiltration analysis and the different phenotypes of macrophages during muscle remodeling by immunostaining (positive for CD68, CD80, CD163, CD206 and elastase). The images were analyzed and quantified using the Image J software (National Institute of Health - NIH, USA). Statistical analysis of data was performed according to evaluating the distribution of the same by & Kolmogorov Smirnov test. Treatment with US generated in the damaged areas of the treated muscles, reduction in the number of neutrophils (elastase +) during the periods 1 and 2 days, an increase of M1 macrophages (CD80 +) in one day period and reducing them in periods of 2, 3 and 7 days. It was also noted when comparing the injured muscles untreated, the US generated reduced profile macrophages M2a (CD206 +) on day 2 and increased this phenotype cells present on day 3. The labeling of total macrophages (CD68 +) uS-treated animals was lower than that present in untreated animals on days 2, 3 and 7. There was no difference in other temporal comparisons. As continuity and the intensity of cells presence with pro or anti inflammatory action can leading to chronic inflammation or fibrosis cases, attesting the US's ability can modulate the occurrence of these cells is an important step in understanding the therapeutic potential of this resource in the treatment of muscle injuries. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-12-10 |
dc.date.accessioned.fl_str_mv |
2018-06-19T13:32:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Silva Junior, Evaldo Moreira da. Efeito do ultrassom pulsado de baixa intensidade sobre o infiltrado inflamat??rio presente no m??sculo esquel??tico ap??s les??o aguda. 2015. 62 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/1803 |
identifier_str_mv |
Silva Junior, Evaldo Moreira da. Efeito do ultrassom pulsado de baixa intensidade sobre o infiltrado inflamat??rio presente no m??sculo esquel??tico ap??s les??o aguda. 2015. 62 f. Disserta????o( Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o) - Universidade Nove de Julho, S??o Paulo. |
url |
http://bibliotecatede.uninove.br/handle/tede/1803 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
8765449414823306929 |
dc.relation.confidence.fl_str_mv |
600 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Nove de Julho |
dc.publisher.program.fl_str_mv |
Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o |
dc.publisher.initials.fl_str_mv |
UNINOVE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Sa??de |
publisher.none.fl_str_mv |
Universidade Nove de Julho |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da Uninove instname:Universidade Nove de Julho (UNINOVE) instacron:UNINOVE |
instname_str |
Universidade Nove de Julho (UNINOVE) |
instacron_str |
UNINOVE |
institution |
UNINOVE |
reponame_str |
Biblioteca Digital de Teses e Dissertações da Uninove |
collection |
Biblioteca Digital de Teses e Dissertações da Uninove |
bitstream.url.fl_str_mv |
http://localhost:8080/tede/bitstream/tede/1803/2/Evaldo+Moreira+da+Silva+Junior.pdf http://localhost:8080/tede/bitstream/tede/1803/1/license.txt |
bitstream.checksum.fl_str_mv |
3c8938d092baff83e502672b6d6a1b69 bd3efa91386c1718a7f26a329fdcb468 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE) |
repository.mail.fl_str_mv |
bibliotecatede@uninove.br||bibliotecatede@uninove.br |
_version_ |
1797250754740748288 |