Efeito do canabidiol no processo cicatricial de defeitos ?sseos cr?ticos mecanicamente induzidos em calota craniana de ratos : avalia??o cl?nica e histol?gica
Ano de defesa: | 2018 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Pontif?cia Universidade Cat?lica do Rio Grande do Sul
|
Programa de Pós-Graduação: |
Programa de P?s-Gradua??o em Odontologia
|
Departamento: |
Escola de Ci?ncias da Sa?de
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://tede2.pucrs.br/tede2/handle/tede/8189 |
Resumo: | Maxillofacial fractures of traumatic origin have a high incidence in the world population. These can be treated in different ways, ranging from conservative methods to widely invasive procedures. Among the multiple possibilities of treatment of this type of disease is the use of herbal medicines, where cannabidiol (CBD) is inserted. This is the main non-psychomimetic component of Cannabis sativa (Can-ns) and plays potent anti-inflammatory, antioxidant and analgesic effects in a variety of pathological conditions. The present dissertation is structured in the form of 2 scientific papers. The first one consists of a literature review, whose objective was to evaluate the mechanisms of action of CBD that may be involved in bone repair. The results of this study suggest that CBD is unable substance of interfering in the healing process of bone defects from its anti-inflammatory and antioxidant potential. The second is an experiment in an animal model, using 64 Wistar rats, divided into two groups (test with CBD and control). At the periods of two, four, six and eight weeks, they were evaluated clinically and histologically in the cicatricial process of mechanically induced bone defects in the skull cap of rats. It was found that the CBD exerted a beneficial effect in the fourth week after treatment where an increase in the mean of neoformed bone within the defect was observed, however, no statistically significant difference was observed in the healing process of the bone defects at the times analyzed. These results suggest the need to deepen the theme, aiming at a better understanding of the possible effects of CBD on bone metabolism and repair. |
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Figueiredo, Maria Ant?nia Zancanaro dehttp://lattes.cnpq.br/7020624513991209http://lattes.cnpq.br/6252302386335213Noronha, Rafael de Ara?jo2018-07-04T14:52:03Z2018-03-28http://tede2.pucrs.br/tede2/handle/tede/8189Maxillofacial fractures of traumatic origin have a high incidence in the world population. These can be treated in different ways, ranging from conservative methods to widely invasive procedures. Among the multiple possibilities of treatment of this type of disease is the use of herbal medicines, where cannabidiol (CBD) is inserted. This is the main non-psychomimetic component of Cannabis sativa (Can-ns) and plays potent anti-inflammatory, antioxidant and analgesic effects in a variety of pathological conditions. The present dissertation is structured in the form of 2 scientific papers. The first one consists of a literature review, whose objective was to evaluate the mechanisms of action of CBD that may be involved in bone repair. The results of this study suggest that CBD is unable substance of interfering in the healing process of bone defects from its anti-inflammatory and antioxidant potential. The second is an experiment in an animal model, using 64 Wistar rats, divided into two groups (test with CBD and control). At the periods of two, four, six and eight weeks, they were evaluated clinically and histologically in the cicatricial process of mechanically induced bone defects in the skull cap of rats. It was found that the CBD exerted a beneficial effect in the fourth week after treatment where an increase in the mean of neoformed bone within the defect was observed, however, no statistically significant difference was observed in the healing process of the bone defects at the times analyzed. These results suggest the need to deepen the theme, aiming at a better understanding of the possible effects of CBD on bone metabolism and repair.As fraturas ?sseas bucofaciais de origem traum?tica possuem uma elevada incid?ncia na popula??o mundial. Estas podem ser tratadas de distintas formas, que variam desde m?todos conservadores at? procedimentos amplamente invasivos. Dentre as m?ltiplas possibilidades de tratamento deste tipo de enfermidade, est? a utiliza??o de fitoter?picos, onde insere-se o canabidiol (CBD). Esse ? o principal componente n?o-psicomim?tico da Cannabis sativa (Can-ns) e desempenha potentes efeitos anti-inflamat?rios, antioxidantes e analg?sicos em diversas condi??es patol?gicas. A presente disserta??o est? estruturada na forma de 2 artigos cient?ficos. No primeiro foi realizada uma revis?o de literatura, cujo objetivo foi avaliar os mecanismos de a??o do CBD que possam estar envolvidos no reparo ?sseo. Os resultados deste estudo sugerem que o CBD ? uma subst?ncia capaz de interferir no processo cicatricial de defeitos ?sseos a partir do seu potencial antiinflamat?rio. O segundo trata de um experimento desenvolvido em modelo animal, utilizando 64 ratos Wistar, divididos randomicamente em 2 grupos (teste com CBD e controle). Avaliou-se cl?nica e histologicamente o efeito da administra??o intraperitoneal do CBD, na dose de 10 mg/kg/dia, por duas, 4, 6 e 8 semanas, no processo cicatricial de defeitos ?sseos mecanicamente induzidos em calota craniana de ratos. Constatou-se que o CDB exerceu um efeito ben?fico na quarta semana p?s tratamento onde observou-se um aumento na m?dia de osso neoformado no interior do defeito. Contudo n?o foi observada diferen?a estatisticamente significativa no processo cicatricial dos defeitos ?sseos nos tempos analisados. Estes resultados sugerem a necessidade de aprofundar o tema, visando uma melhor compreens?o sobre poss?veis efeitos do uso do CBD no metabolismo e reparo ?sseo.Submitted by PPG Odontologia (odontologia-pg@pucrs.br) on 2018-06-27T16:07:31Z No. of bitstreams: 1 RAFAEL_DE_ARAUJO_NORONHA_DIS.pdf: 673617 bytes, checksum: 0e6162f0003c8204cabce0b4b4b0a140 (MD5)Approved for entry into archive by Sheila Dias (sheila.dias@pucrs.br) on 2018-07-04T14:34:33Z (GMT) No. of bitstreams: 1 RAFAEL_DE_ARAUJO_NORONHA_DIS.pdf: 673617 bytes, checksum: 0e6162f0003c8204cabce0b4b4b0a140 (MD5)Made available in DSpace on 2018-07-04T14:52:03Z (GMT). No. of bitstreams: 1 RAFAEL_DE_ARAUJO_NORONHA_DIS.pdf: 673617 bytes, checksum: 0e6162f0003c8204cabce0b4b4b0a140 (MD5) Previous issue date: 2018-03-28Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPESapplication/pdfhttp://tede2.pucrs.br:80/tede2/retrieve/172723/RAFAEL_DE_ARAUJO_NORONHA_DIS.pdf.jpgporPontif?cia Universidade Cat?lica do Rio Grande do SulPrograma de P?s-Gradua??o em OdontologiaPUCRSBrasilEscola de Ci?ncias da Sa?deCanabidiolCanabinoidesCannabis SativaConsolida??o da FraturaRegenera??o ?sseaPatologia ?sseaCannabidiolCannabinoidsCannabis SativaBone RegenerationFracture HealingBone PathologyCIENCIAS DA SAUDE::ODONTOLOGIAEfeito do canabidiol no processo cicatricial de defeitos ?sseos cr?ticos mecanicamente induzidos em calota craniana de ratos : avalia??o cl?nica e histol?gicainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisTrabalho n?o apresenta restri??o para publica??o-8096554818733665164500500600-20704984698792443492075167498588264571info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da PUC_RSinstname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSTHUMBNAILRAFAEL_DE_ARAUJO_NORONHA_DIS.pdf.jpgRAFAEL_DE_ARAUJO_NORONHA_DIS.pdf.jpgimage/jpeg5142http://tede2.pucrs.br/tede2/bitstream/tede/8189/4/RAFAEL_DE_ARAUJO_NORONHA_DIS.pdf.jpg3119fd00d65697b72d5394ac311a02ccMD54TEXTRAFAEL_DE_ARAUJO_NORONHA_DIS.pdf.txtRAFAEL_DE_ARAUJO_NORONHA_DIS.pdf.txttext/plain97182http://tede2.pucrs.br/tede2/bitstream/tede/8189/3/RAFAEL_DE_ARAUJO_NORONHA_DIS.pdf.txtd31ceb0d20ed1b169d514cc7c1aab913MD53ORIGINALRAFAEL_DE_ARAUJO_NORONHA_DIS.pdfRAFAEL_DE_ARAUJO_NORONHA_DIS.pdfapplication/pdf673617http://tede2.pucrs.br/tede2/bitstream/tede/8189/2/RAFAEL_DE_ARAUJO_NORONHA_DIS.pdf0e6162f0003c8204cabce0b4b4b0a140MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8610http://tede2.pucrs.br/tede2/bitstream/tede/8189/1/license.txt5a9d6006225b368ef605ba16b4f6d1beMD51tede/81892018-07-04 12:01:19.282oai:tede2.pucrs.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.pucrs.br/tede2/PRIhttps://tede2.pucrs.br/oai/requestbiblioteca.central@pucrs.br||opendoar:2018-07-04T15:01:19Biblioteca Digital de Teses e Dissertações da PUC_RS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.por.fl_str_mv |
Efeito do canabidiol no processo cicatricial de defeitos ?sseos cr?ticos mecanicamente induzidos em calota craniana de ratos : avalia??o cl?nica e histol?gica |
title |
Efeito do canabidiol no processo cicatricial de defeitos ?sseos cr?ticos mecanicamente induzidos em calota craniana de ratos : avalia??o cl?nica e histol?gica |
spellingShingle |
Efeito do canabidiol no processo cicatricial de defeitos ?sseos cr?ticos mecanicamente induzidos em calota craniana de ratos : avalia??o cl?nica e histol?gica Noronha, Rafael de Ara?jo Canabidiol Canabinoides Cannabis Sativa Consolida??o da Fratura Regenera??o ?ssea Patologia ?ssea Cannabidiol Cannabinoids Cannabis Sativa Bone Regeneration Fracture Healing Bone Pathology CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Efeito do canabidiol no processo cicatricial de defeitos ?sseos cr?ticos mecanicamente induzidos em calota craniana de ratos : avalia??o cl?nica e histol?gica |
title_full |
Efeito do canabidiol no processo cicatricial de defeitos ?sseos cr?ticos mecanicamente induzidos em calota craniana de ratos : avalia??o cl?nica e histol?gica |
title_fullStr |
Efeito do canabidiol no processo cicatricial de defeitos ?sseos cr?ticos mecanicamente induzidos em calota craniana de ratos : avalia??o cl?nica e histol?gica |
title_full_unstemmed |
Efeito do canabidiol no processo cicatricial de defeitos ?sseos cr?ticos mecanicamente induzidos em calota craniana de ratos : avalia??o cl?nica e histol?gica |
title_sort |
Efeito do canabidiol no processo cicatricial de defeitos ?sseos cr?ticos mecanicamente induzidos em calota craniana de ratos : avalia??o cl?nica e histol?gica |
author |
Noronha, Rafael de Ara?jo |
author_facet |
Noronha, Rafael de Ara?jo |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Figueiredo, Maria Ant?nia Zancanaro de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/7020624513991209 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6252302386335213 |
dc.contributor.author.fl_str_mv |
Noronha, Rafael de Ara?jo |
contributor_str_mv |
Figueiredo, Maria Ant?nia Zancanaro de |
dc.subject.por.fl_str_mv |
Canabidiol Canabinoides Cannabis Sativa Consolida??o da Fratura Regenera??o ?ssea Patologia ?ssea |
topic |
Canabidiol Canabinoides Cannabis Sativa Consolida??o da Fratura Regenera??o ?ssea Patologia ?ssea Cannabidiol Cannabinoids Cannabis Sativa Bone Regeneration Fracture Healing Bone Pathology CIENCIAS DA SAUDE::ODONTOLOGIA |
dc.subject.eng.fl_str_mv |
Cannabidiol Cannabinoids Cannabis Sativa Bone Regeneration Fracture Healing Bone Pathology |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
Maxillofacial fractures of traumatic origin have a high incidence in the world population. These can be treated in different ways, ranging from conservative methods to widely invasive procedures. Among the multiple possibilities of treatment of this type of disease is the use of herbal medicines, where cannabidiol (CBD) is inserted. This is the main non-psychomimetic component of Cannabis sativa (Can-ns) and plays potent anti-inflammatory, antioxidant and analgesic effects in a variety of pathological conditions. The present dissertation is structured in the form of 2 scientific papers. The first one consists of a literature review, whose objective was to evaluate the mechanisms of action of CBD that may be involved in bone repair. The results of this study suggest that CBD is unable substance of interfering in the healing process of bone defects from its anti-inflammatory and antioxidant potential. The second is an experiment in an animal model, using 64 Wistar rats, divided into two groups (test with CBD and control). At the periods of two, four, six and eight weeks, they were evaluated clinically and histologically in the cicatricial process of mechanically induced bone defects in the skull cap of rats. It was found that the CBD exerted a beneficial effect in the fourth week after treatment where an increase in the mean of neoformed bone within the defect was observed, however, no statistically significant difference was observed in the healing process of the bone defects at the times analyzed. These results suggest the need to deepen the theme, aiming at a better understanding of the possible effects of CBD on bone metabolism and repair. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-07-04T14:52:03Z |
dc.date.issued.fl_str_mv |
2018-03-28 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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masterThesis |
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publishedVersion |
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http://tede2.pucrs.br/tede2/handle/tede/8189 |
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http://tede2.pucrs.br/tede2/handle/tede/8189 |
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por |
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por |
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500 500 600 |
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2075167498588264571 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Pontif?cia Universidade Cat?lica do Rio Grande do Sul |
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Programa de P?s-Gradua??o em Odontologia |
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PUCRS |
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Brasil |
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Escola de Ci?ncias da Sa?de |
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Pontif?cia Universidade Cat?lica do Rio Grande do Sul |
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