Gels and sponges nanocomposites based in chitosan, poly (n-vinyl caprolactam) and sio2 applied as drug delivery system

Detalhes bibliográficos
Ano de defesa: 2023
Autor(a) principal: Cutrim, Fiama Martins
Orientador(a): Camargo, Emerson Rodrigues de lattes
Banca de defesa: Não Informado pela instituição
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: eng
Instituição de defesa: Universidade Federal de São Carlos
Câmpus São Carlos
Programa de Pós-Graduação: Programa de Pós-Graduação em Química - PPGQ
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Inglês:
Chitosan
PNVCL
SiO2
Área do conhecimento CNPq:
CIENCIAS EXATAS E DA TERRA::QUIMICA::FISICO-QUIMICA
Link de acesso: https://repositorio.ufscar.br/handle/20.500.14289/18255
Resumo: Chitosan (Ch) is a suitable biomaterial for biological applications like drug delivery systems (DDS) due to biocompatibility, cationic responsiveness, and adjustable morphology forming nanoparticles, films, sponges, etc. For these reasons, this study reports the results of the synthesis and characterization of chitosan composite with poly (n-vinyl caprolactam) (PNVCL) and SiO2 for the application as DDS for the treatment of vulvovaginal candidiasis (VVC). The materials loaded with clotrimazole (CTZ) were obtained. The physical-chemical properties show that the materials have good thermal stability considering the application. The biomechanical properties are adequate and can be adjusted according to the insertion of PNVCL or PNVCL-SiO2. The materials were tested for activity against Candida species, and the antifungal activity was maintained with the drug associated with the materials. Cytotoxicity studies using female genital tract cell lines were performed, showing biocompatibility. According to the results obtained so far, the chitosan sponges and its composites appear to be an excellent formulation to be used in the treatment of VVC because they can maintain the antifungal activity of CTZ and due to their biocompatibility.
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spelling Cutrim, Fiama MartinsCamargo, Emerson Rodrigues dehttp://lattes.cnpq.br/7720754304065239Neves, José dashttp://lattes.cnpq.br/7420241120849172ce6aa3d0-7a32-4985-adc9-456acbed3a032023-07-10T14:33:30Z2023-07-10T14:33:30Z2023-06-14CUTRIM, Fiama Martins. Gels and sponges nanocomposites based in chitosan, poly (n-vinyl caprolactam) and sio2 applied as drug delivery system. 2023. Tese (Doutorado em Química) – Universidade Federal de São Carlos, São Carlos, 2023. Disponível em: https://repositorio.ufscar.br/handle/20.500.14289/18255.https://repositorio.ufscar.br/handle/20.500.14289/18255Chitosan (Ch) is a suitable biomaterial for biological applications like drug delivery systems (DDS) due to biocompatibility, cationic responsiveness, and adjustable morphology forming nanoparticles, films, sponges, etc. For these reasons, this study reports the results of the synthesis and characterization of chitosan composite with poly (n-vinyl caprolactam) (PNVCL) and SiO2 for the application as DDS for the treatment of vulvovaginal candidiasis (VVC). The materials loaded with clotrimazole (CTZ) were obtained. The physical-chemical properties show that the materials have good thermal stability considering the application. The biomechanical properties are adequate and can be adjusted according to the insertion of PNVCL or PNVCL-SiO2. The materials were tested for activity against Candida species, and the antifungal activity was maintained with the drug associated with the materials. Cytotoxicity studies using female genital tract cell lines were performed, showing biocompatibility. According to the results obtained so far, the chitosan sponges and its composites appear to be an excellent formulation to be used in the treatment of VVC because they can maintain the antifungal activity of CTZ and due to their biocompatibility.GÉIS E ESPONJAS NANOCOMPÓSITOS A BASE DE QUITOSANA, POLI (N-VINIL CAPROLACTAMA) E SIO2 APLICADOS COMO SISTEMAS DE LIBERAÇÃO DE MEDICAMENTOS. Quitosana é um biomaterial promissor para ablicação biológica como em sistemas de liberação de medicamentos (DDS) devido a características como biocompatibilidade, responsividade catiónica, ajuste da morfologia, podendo formar nanopartículas, filmes, esponjas, etc. Por isso, esse estudo reporta os resultados da síntese e caracterização de compósitos de quitosana com poli (n-vinil caprolactama) (PNVCL) e SiO2 para aplicação como DDS para o tratamento de candidíase vulvovaginal (VVC). Foram obtidas esponjas desses materiais e também esponjas carregadas com clotrimazol (CTZ). As propriedades físico-químicas estudadas, mostraram que os materiais possuem características térmicas adequadas considerando sua aplicação. O estudo das propriedades biomecanicas mostraram que os compósitos são adequados para aplicação e que a rigidez pode ser ajustada com a inserção de PNVCL ou PNVCL-SiO2. Os materiais foram testados para atividade anti candida na qual observou-se que a atividade do fármaco foi mantida com sua associação aos biomateriais. O estudo da citotoxicidade usando linhas celulares do trato vaginal feminino indicou a biocompatibilidade dos materiais. De acordo com os resultados, as esponjas de quitosana e seus compósitos são promissoras para aplicação no tratamento de candidíase vulvovaginal devido à sua capacidade de manter a atividade do fármaco e serem biocompatíveis.Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico do Maranhão (FAPEMA)BD-02176/19engUniversidade Federal de São CarlosCâmpus São CarlosPrograma de Pós-Graduação em Química - PPGQUFSCarAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessChitosanPNVCLSiO2CIENCIAS EXATAS E DA TERRA::QUIMICA::FISICO-QUIMICAGels and sponges nanocomposites based in chitosan, poly (n-vinyl caprolactam) and sio2 applied as drug delivery systemGéis e esponjas nanocompósitos a base de quitosana, poli (n-vinil caprolactama) e SiO2 aplicados como sistemas de liberação de medicamentosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis6006005082eee2-7a17-49c1-9a15-2a479b52df0freponame:Repositório Institucional da UFSCARinstname:Universidade Federal de São Carlos (UFSCAR)instacron:UFSCARTHUMBNAILFMC_tesefinal.pdf.jpgFMC_tesefinal.pdf.jpgGenerated Thumbnailimage/jpeg6198https://repositorio.ufscar.br/bitstreams/9e8c90e6-70b2-42c2-b6af-cc2df6b63296/downloadf4a8d483ffd31dbfb16fd45ec0322bcfMD59falseAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8810https://repositorio.ufscar.br/bitstreams/314c854b-42b9-4c10-97b5-470bdd01b072/downloadf337d95da1fce0a22c77480e5e9a7aecMD56falseAnonymousREADORIGINALFMC_tesefinal.pdfFMC_tesefinal.pdfTese de Doutoradoapplication/pdf4670356https://repositorio.ufscar.br/bitstreams/f21822ff-090d-4181-b5e7-20d3042ceeab/downloadfdd80564f8c92029d389b8e281839685MD57trueAnonymousREADTEXTFMC_tesefinal.pdf.txtFMC_tesefinal.pdf.txtExtracted texttext/plain147145https://repositorio.ufscar.br/bitstreams/6a5b9514-4cab-4844-80ff-37207123f431/download98d042ddd985f034922ce4b611788e0bMD58falseAnonymousREAD20.500.14289/182552025-02-05 23:58:59.561http://creativecommons.org/licenses/by-nc-nd/3.0/br/Attribution-NonCommercial-NoDerivs 3.0 Brazilopen.accessoai:repositorio.ufscar.br:20.500.14289/18255https://repositorio.ufscar.brRepositório InstitucionalPUBhttps://repositorio.ufscar.br/oai/requestrepositorio.sibi@ufscar.bropendoar:43222025-02-06T02:58:59Repositório Institucional da UFSCAR - Universidade Federal de São Carlos (UFSCAR)false
dc.title.eng.fl_str_mv Gels and sponges nanocomposites based in chitosan, poly (n-vinyl caprolactam) and sio2 applied as drug delivery system
dc.title.alternative.por.fl_str_mv Géis e esponjas nanocompósitos a base de quitosana, poli (n-vinil caprolactama) e SiO2 aplicados como sistemas de liberação de medicamentos
title Gels and sponges nanocomposites based in chitosan, poly (n-vinyl caprolactam) and sio2 applied as drug delivery system
spellingShingle Gels and sponges nanocomposites based in chitosan, poly (n-vinyl caprolactam) and sio2 applied as drug delivery system
Cutrim, Fiama Martins
Chitosan
PNVCL
SiO2
CIENCIAS EXATAS E DA TERRA::QUIMICA::FISICO-QUIMICA
title_short Gels and sponges nanocomposites based in chitosan, poly (n-vinyl caprolactam) and sio2 applied as drug delivery system
title_full Gels and sponges nanocomposites based in chitosan, poly (n-vinyl caprolactam) and sio2 applied as drug delivery system
title_fullStr Gels and sponges nanocomposites based in chitosan, poly (n-vinyl caprolactam) and sio2 applied as drug delivery system
title_full_unstemmed Gels and sponges nanocomposites based in chitosan, poly (n-vinyl caprolactam) and sio2 applied as drug delivery system
title_sort Gels and sponges nanocomposites based in chitosan, poly (n-vinyl caprolactam) and sio2 applied as drug delivery system
author Cutrim, Fiama Martins
author_facet Cutrim, Fiama Martins
author_role author
dc.contributor.authorlattes.por.fl_str_mv http://lattes.cnpq.br/7420241120849172
dc.contributor.author.fl_str_mv Cutrim, Fiama Martins
dc.contributor.advisor1.fl_str_mv Camargo, Emerson Rodrigues de
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/7720754304065239
dc.contributor.advisor-co1.fl_str_mv Neves, José das
dc.contributor.authorID.fl_str_mv ce6aa3d0-7a32-4985-adc9-456acbed3a03
contributor_str_mv Camargo, Emerson Rodrigues de
Neves, José das
dc.subject.eng.fl_str_mv Chitosan
PNVCL
SiO2
topic Chitosan
PNVCL
SiO2
CIENCIAS EXATAS E DA TERRA::QUIMICA::FISICO-QUIMICA
dc.subject.cnpq.fl_str_mv CIENCIAS EXATAS E DA TERRA::QUIMICA::FISICO-QUIMICA
description Chitosan (Ch) is a suitable biomaterial for biological applications like drug delivery systems (DDS) due to biocompatibility, cationic responsiveness, and adjustable morphology forming nanoparticles, films, sponges, etc. For these reasons, this study reports the results of the synthesis and characterization of chitosan composite with poly (n-vinyl caprolactam) (PNVCL) and SiO2 for the application as DDS for the treatment of vulvovaginal candidiasis (VVC). The materials loaded with clotrimazole (CTZ) were obtained. The physical-chemical properties show that the materials have good thermal stability considering the application. The biomechanical properties are adequate and can be adjusted according to the insertion of PNVCL or PNVCL-SiO2. The materials were tested for activity against Candida species, and the antifungal activity was maintained with the drug associated with the materials. Cytotoxicity studies using female genital tract cell lines were performed, showing biocompatibility. According to the results obtained so far, the chitosan sponges and its composites appear to be an excellent formulation to be used in the treatment of VVC because they can maintain the antifungal activity of CTZ and due to their biocompatibility.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-07-10T14:33:30Z
dc.date.available.fl_str_mv 2023-07-10T14:33:30Z
dc.date.issued.fl_str_mv 2023-06-14
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv CUTRIM, Fiama Martins. Gels and sponges nanocomposites based in chitosan, poly (n-vinyl caprolactam) and sio2 applied as drug delivery system. 2023. Tese (Doutorado em Química) – Universidade Federal de São Carlos, São Carlos, 2023. Disponível em: https://repositorio.ufscar.br/handle/20.500.14289/18255.
dc.identifier.uri.fl_str_mv https://repositorio.ufscar.br/handle/20.500.14289/18255
identifier_str_mv CUTRIM, Fiama Martins. Gels and sponges nanocomposites based in chitosan, poly (n-vinyl caprolactam) and sio2 applied as drug delivery system. 2023. Tese (Doutorado em Química) – Universidade Federal de São Carlos, São Carlos, 2023. Disponível em: https://repositorio.ufscar.br/handle/20.500.14289/18255.
url https://repositorio.ufscar.br/handle/20.500.14289/18255
dc.language.iso.fl_str_mv eng
language eng
dc.relation.confidence.fl_str_mv 600
600
dc.relation.authority.fl_str_mv 5082eee2-7a17-49c1-9a15-2a479b52df0f
dc.rights.driver.fl_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de São Carlos
Câmpus São Carlos
dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Química - PPGQ
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publisher.none.fl_str_mv Universidade Federal de São Carlos
Câmpus São Carlos
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