Obtenção de estruturas porosas altamente bioativas via sinterização do Biosilicato®

• Ano de defesa: 2009
• Autor(a) principal: Crovace, Murilo Camuri
• Orientador(a): Rodrigues, Ana Candida Martins
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Carlos
• Programa de Pós-Graduação: Programa de Pós-Graduação em Ciência e Engenharia de Materiais - PPGCEM
• País: BR
• Palavras-chave em Português: Engenharia de materiais; Biomateriais; Ossos - enxerto; Vitrocerâmica; Biosilicato
• Área do conhecimento CNPq: ENGENHARIAS::ENGENHARIA DE MATERIAIS E METALURGICA
• Link de acesso: https://repositorio.ufscar.br/handle/20.500.14289/813

In the present work, scaffolds were obtained through the controlled sintering of Biosilicate®. This material possesses good mechanical properties and its bioactivity level is comparable to that of bioglasses, making it an interesting candidate for use as a scaffold to stimulate bone tissue regeneration. Previous studies have found that a secondary crystalline phase is formed when Biosilicate® is heat-treated at high temperatures (T > 700°C). The in vitro bioactivity tests revealed that the presence of the secondary phase is not harmful, but instead enhances the bioactivity of Biosilicate® to a level comparable to that of Bioglass - 45S5. Two different techniques were used in the synthesis of scaffolds: (1) the addition of porogen agents, and (2) the replication method. Five porogen agents were tested and compared: naphthalene, cassava starch, corn starch, polyethylene beads and carbon black. The first technique yielded scaffolds with a total porosity of 67 to 87% in a highly interconnected porous structure. The best result was achieved with carbon black, which resulted in an average pore size of 230 μm and a total porosity of 87%, making it the most promising porogen agent for application as a scaffold. The replication technique led to the formation of scaffolds with a total porosity of 96% and open cells in the range of 435 945 μm, with an average cell size of 650 μm.