Investigação dos efeitos do treinamento de força sobre os níveis de hepcidina e biodisponibilidade de ferro em indivíduos idosos com doença renal em estágio terminal

• Ano de defesa: 2022
• Autor(a) principal: Moura, Sting Ray Gouveia
• Orientador(a): Rosa, Thiago dos Santos
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Católica de Brasília
• Programa de Pós-Graduação: Programa Stricto Sensu em Educação Física
• Departamento: Escola de Saúde e Medicina
• País: Brasil
• Palavras-chave em Português: Doença renal crônica; Treinamento de força; Metabolismo do ferro; Anemia; Diálise; Idosos
• Palavras-chave em Inglês: Dialysis; Old man; Iron metabolism; Strength Training; Chronic kidney disease
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA
• Link de acesso: https://bdtd.ucb.br:8443/jspui/handle/tede/3240

Chronic kidney disease (CKD) is determined as changes in kidney structure or function. Patients with end-stage renal disease have low availability of serum iron and anemia is one of the most common complications in chronic kidney disease and cardiovascular diseases are the main cause of morbidity and mortality. Physical training becomes a relevant treatment for anemia in elderly people with terminal chronic disease. Therefore, this project aims to: examine, in a 6-month period, the effects of Strength Training on the inflammatory profile, hepcidin and iron bioavailability in elderly people with end-stage renal disease. Regarding the methodological aspects, this is an experimental study, carried out in a period of six months of intervention, in end-stage chronic renal patients at the CINE (Integrated Center of Nephrology), HDC (Hemo Dialysis Center) and Renal Class clinics. The research was carried out with 157 patients with chronic kidney disease undergoing hemodialysis aged 60 years or older, able to practice physical exercises. Partial results showed that there was a significant increase in iron and a decrease in hepcidin in the strength training group compared to the control group. However, there were no significant differences for hemoglobin and ferritin. There was a significant decrease in TNF-α and IL-6 after the intervention. These results that strength training exercise may be a relevant therapy for CKD-related anemia. The present study opens perspective for the clinical application of Strength Training as an effective tool for future guidelines in the treatment of anemia in elderly individuals with end-stage CKD due to the potential effect on hepcidin reduction.