Avalia??o do potencial antinociceptivo do polissacar?deo obtido a partir da levedura Rhodotorulaoryzicola
| Ano de defesa: | 2017 |
|---|---|
| Autor(a) principal: | |
| Orientador(a): | |
| Banca de defesa: | |
| Tipo de documento: | Dissertação |
| Tipo de acesso: | Acesso aberto |
| Idioma: | por |
| Instituição de defesa: |
Universidade Estadual de Feira de Santana
|
| Programa de Pós-Graduação: |
Mestrado Acad?mico em Biotecnologia
|
| Departamento: |
DEPARTAMENTO DE CI?NCIAS BIOL?GICAS
|
| País: |
Brasil
|
| Palavras-chave em Português: | |
| Palavras-chave em Inglês: | |
| Área do conhecimento CNPq: | |
| Link de acesso: | http://tede2.uefs.br:8080/handle/tede/793 |
Resumo: | The yeasts are constituted by different macromolecules, among them the polysaccharides. The pharmaceutical industry has used polysaccharides as an important raw material for the development of new drugs, since they present several pharmacological activities, such as antitumor, antioxidant, anti-inflammatory, antinociceptive and immunomodulatory activities. The yeast Rhodotorulaoryzicola, present in the semi-arid region of Bahia, deserves to be highlighted, since it is still little explored in relation to its biotechnological potential. The present study analyzed the possible antinociceptive effect of the polysaccharide obtained from yeast R. oryzicola, through pain models in mice. This study was approved by the Commission of Ethics in the Use of Animals of the State University of Feira de Santana (06/2013). Intraperitoneal administration of the polysaccharide (9 and 27 mg/kg) showed dose-dependent inhibition of the number of abdominal writhes induced by acetic acid. In the formalin test, pre-treatment with the polysaccharide (27 mg/kg) showed antinociceptive activity only in the second phase of the test. It was observed that the polysaccharide (9, 27 and 81 mg/kg) altered the thermal stimulus response threshold used in the tail withdrawal test, thus indicating a possible central action presence. In the model of mechanical hypernociception induced by CFA, pre-treatment with the polysaccharide (27 and 81 mg/kg) inhibited CFA-induced hypernociception. Ratifying the specificity of the antinociceptive action, the polysaccharide (27 mg/kg) did not change the motor behavior of the animals in the rota rod and open field models. The structural characterization showed mannosyl residues involved in ?-3,6-type binding, suggesting that the sample is amannan. The results demonstrate that the polysaccharide has an efficient antinociceptive activity, indicating its development for the treatment of inflammatory pain conditions |
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Lima, Fl?via Oliveirahttp://lattes.cnpq.br/896516732630485505290576541http://lattes.cnpq.br/2268657707580890Ferraz, Fl?via Menezes2019-07-15T22:15:33Z2017-09-28FERRAZ, Fl?via Menezes. Avalia??o do potencial antinociceptivo do polissacar?deo obtido a partir da levedura Rhodotorulaoryzicola. 2017. 64f. Disserta??o (Mestrado Acad?mico em Biotecnologia) - Universidade Estadual de Feira de Santana, Feira de Santana, 2017.http://tede2.uefs.br:8080/handle/tede/793The yeasts are constituted by different macromolecules, among them the polysaccharides. The pharmaceutical industry has used polysaccharides as an important raw material for the development of new drugs, since they present several pharmacological activities, such as antitumor, antioxidant, anti-inflammatory, antinociceptive and immunomodulatory activities. The yeast Rhodotorulaoryzicola, present in the semi-arid region of Bahia, deserves to be highlighted, since it is still little explored in relation to its biotechnological potential. The present study analyzed the possible antinociceptive effect of the polysaccharide obtained from yeast R. oryzicola, through pain models in mice. This study was approved by the Commission of Ethics in the Use of Animals of the State University of Feira de Santana (06/2013). Intraperitoneal administration of the polysaccharide (9 and 27 mg/kg) showed dose-dependent inhibition of the number of abdominal writhes induced by acetic acid. In the formalin test, pre-treatment with the polysaccharide (27 mg/kg) showed antinociceptive activity only in the second phase of the test. It was observed that the polysaccharide (9, 27 and 81 mg/kg) altered the thermal stimulus response threshold used in the tail withdrawal test, thus indicating a possible central action presence. In the model of mechanical hypernociception induced by CFA, pre-treatment with the polysaccharide (27 and 81 mg/kg) inhibited CFA-induced hypernociception. Ratifying the specificity of the antinociceptive action, the polysaccharide (27 mg/kg) did not change the motor behavior of the animals in the rota rod and open field models. The structural characterization showed mannosyl residues involved in ?-3,6-type binding, suggesting that the sample is amannan. The results demonstrate that the polysaccharide has an efficient antinociceptive activity, indicating its development for the treatment of inflammatory pain conditionsAs leveduras s?o constitu?das por diferentes macromol?culas, dentre elas os polissacar?deos. A ind?stria farmac?utica tem utilizado os polissacar?deos como uma importante mat?ria-prima para o desenvolvimento de novos medicamentos, uma vez que estes apresentam diversas atividades farmacol?gicas, a exemplo das atividades antitumoral, antioxidante, anti-inflamat?ria, antinociceptiva e imunomoduladora. A levedura Rhodotorulaoryzicola, presente no semi?rido baiano, merece destaque visto que ainda ? pouco explorada em rela??o a seu potencial biotecnol?gico. O presente trabalho analisou o poss?vel efeito antinociceptivo do polissacar?deo obtido a partir da levedura R. oryzicola, atrav?s de modelos de dor em camundongos. Este estudo foi aprovado pela Comiss?o de ?tica no Uso de Animais da Universidade Estadual de Feira de Santana (06/2013). A administra??o intraperitoneal do polissacar?deo (9 e 27 mg/kg) apresentou uma inibi??o de modo dose-dependente do n?mero de contor??es abdominais induzidas pelo ?cido ac?tico. No teste de formalina, o pr?-tratamento com o polissacar?deo (27 mg/kg) apresentou atividade antinociceptiva apenas na segunda fase do teste. Observou-se que o polissacar?deo (9, 27 e 81 mg/kg) alterou o limiar de resposta ao est?mulo t?rmico utilizado no teste de retirada de cauda, indicando assim uma poss?vel presen?a de a??o central. No modelo da hipernocicep??o mec?nica induzida por CFA, o pr?-tratamento com o polissacar?deo (27 e 81 mg/kg) inibiu a hipernocicep??o induzida pelo CFA. Ratificando a especificidade da a??o antinociceptiva, o polissacar?deo (27 mg/kg) n?o alterou o comportamento motor dos animais nos modelos do cilindro girat?rio e do campo aberto. A caracteriza??o estrutural mostrou res?duos demanosil envolvidos em liga??o do tipo ?-3,6, sugerindo que a amostra seja uma manana.Os resultados comprovam que o polissacar?deo apresenta uma eficiente atividade antinociceptiva, indicando o desenvolvimento deste para o tratamento de condi??es de dor inflamat?riaSubmitted by Verena Pereira (verenagoncalves@uefs.br) on 2019-07-15T22:15:32Z No. of bitstreams: 1 DISSERTA??O_ESCRITA_VERS?O_FINAL.pdf: 1765139 bytes, checksum: 4484f609260a7e21932357f4b4379b99 (MD5)Made available in DSpace on 2019-07-15T22:15:33Z (GMT). No. of bitstreams: 1 DISSERTA??O_ESCRITA_VERS?O_FINAL.pdf: 1765139 bytes, checksum: 4484f609260a7e21932357f4b4379b99 (MD5) Previous issue date: 2017-09-28application/pdfhttp://tede2.uefs.br:8080/retrieve/5410/DISSERTA%c3%87%c3%83O_ESCRITA_VERS%c3%83O_FINAL.pdf.jpgporUniversidade Estadual de Feira de SantanaMestrado Acad?mico em BiotecnologiaUEFSBrasilDEPARTAMENTO DE CI?NCIAS BIOL?GICASRhodotorulaoryzicolaDorAntinocicep??oPolissacar?deoAntinociceptionPolysaccharideRhodotorulaoryzicolaPainCIENCIAS BIOLOGICAS::FARMACOLOGIAAvalia??o do potencial antinociceptivo do polissacar?deo obtido a partir da levedura Rhodotorulaoryzicolainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-54735432730516527826006006005026123383450589282700814650651154363info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UEFSinstname:Universidade Estadual de Feira de Santana (UEFS)instacron:UEFSTHUMBNAILDISSERTA??O_ESCRITA_VERS?O_FINAL.pdf.jpgDISSERTA??O_ESCRITA_VERS?O_FINAL.pdf.jpgimage/jpeg4089http://tede2.uefs.br:8080/bitstream/tede/793/4/DISSERTA%C3%87%C3%83O_ESCRITA_VERS%C3%83O_FINAL.pdf.jpg0227f73e2bbcd06cb1d54c7caced5df7MD54TEXTDISSERTA??O_ESCRITA_VERS?O_FINAL.pdf.txtDISSERTA??O_ESCRITA_VERS?O_FINAL.pdf.txttext/plain90328http://tede2.uefs.br:8080/bitstream/tede/793/3/DISSERTA%C3%87%C3%83O_ESCRITA_VERS%C3%83O_FINAL.pdf.txt37457cecde2d755c4577cbd3b6ab5cd6MD53ORIGINALDISSERTA??O_ESCRITA_VERS?O_FINAL.pdfDISSERTA??O_ESCRITA_VERS?O_FINAL.pdfapplication/pdf1765139http://tede2.uefs.br:8080/bitstream/tede/793/2/DISSERTA%C3%87%C3%83O_ESCRITA_VERS%C3%83O_FINAL.pdf4484f609260a7e21932357f4b4379b99MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82089http://tede2.uefs.br:8080/bitstream/tede/793/1/license.txt7b5ba3d2445355f386edab96125d42b7MD51tede/7932025-09-10 01:12:07.72oai:tede2.uefs.br:8080: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.uefs.br:8080/PUBhttp://tede2.uefs.br:8080/oai/requestbcuefs@uefs.br|| bcref@uefs.br||bcuefs@uefs.bropendoar:2025-09-10T04:12:07Biblioteca Digital de Teses e Dissertações da UEFS - Universidade Estadual de Feira de Santana (UEFS)false |
| dc.title.por.fl_str_mv |
Avalia??o do potencial antinociceptivo do polissacar?deo obtido a partir da levedura Rhodotorulaoryzicola |
| title |
Avalia??o do potencial antinociceptivo do polissacar?deo obtido a partir da levedura Rhodotorulaoryzicola |
| spellingShingle |
Avalia??o do potencial antinociceptivo do polissacar?deo obtido a partir da levedura Rhodotorulaoryzicola Ferraz, Fl?via Menezes Rhodotorulaoryzicola Dor Antinocicep??o Polissacar?deo Antinociception Polysaccharide Rhodotorulaoryzicola Pain CIENCIAS BIOLOGICAS::FARMACOLOGIA |
| title_short |
Avalia??o do potencial antinociceptivo do polissacar?deo obtido a partir da levedura Rhodotorulaoryzicola |
| title_full |
Avalia??o do potencial antinociceptivo do polissacar?deo obtido a partir da levedura Rhodotorulaoryzicola |
| title_fullStr |
Avalia??o do potencial antinociceptivo do polissacar?deo obtido a partir da levedura Rhodotorulaoryzicola |
| title_full_unstemmed |
Avalia??o do potencial antinociceptivo do polissacar?deo obtido a partir da levedura Rhodotorulaoryzicola |
| title_sort |
Avalia??o do potencial antinociceptivo do polissacar?deo obtido a partir da levedura Rhodotorulaoryzicola |
| author |
Ferraz, Fl?via Menezes |
| author_facet |
Ferraz, Fl?via Menezes |
| author_role |
author |
| dc.contributor.advisor1.fl_str_mv |
Lima, Fl?via Oliveira |
| dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/8965167326304855 |
| dc.contributor.authorID.fl_str_mv |
05290576541 |
| dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/2268657707580890 |
| dc.contributor.author.fl_str_mv |
Ferraz, Fl?via Menezes |
| contributor_str_mv |
Lima, Fl?via Oliveira |
| dc.subject.por.fl_str_mv |
Rhodotorulaoryzicola Dor Antinocicep??o Polissacar?deo Antinociception Polysaccharide |
| topic |
Rhodotorulaoryzicola Dor Antinocicep??o Polissacar?deo Antinociception Polysaccharide Rhodotorulaoryzicola Pain CIENCIAS BIOLOGICAS::FARMACOLOGIA |
| dc.subject.eng.fl_str_mv |
Rhodotorulaoryzicola Pain |
| dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::FARMACOLOGIA |
| description |
The yeasts are constituted by different macromolecules, among them the polysaccharides. The pharmaceutical industry has used polysaccharides as an important raw material for the development of new drugs, since they present several pharmacological activities, such as antitumor, antioxidant, anti-inflammatory, antinociceptive and immunomodulatory activities. The yeast Rhodotorulaoryzicola, present in the semi-arid region of Bahia, deserves to be highlighted, since it is still little explored in relation to its biotechnological potential. The present study analyzed the possible antinociceptive effect of the polysaccharide obtained from yeast R. oryzicola, through pain models in mice. This study was approved by the Commission of Ethics in the Use of Animals of the State University of Feira de Santana (06/2013). Intraperitoneal administration of the polysaccharide (9 and 27 mg/kg) showed dose-dependent inhibition of the number of abdominal writhes induced by acetic acid. In the formalin test, pre-treatment with the polysaccharide (27 mg/kg) showed antinociceptive activity only in the second phase of the test. It was observed that the polysaccharide (9, 27 and 81 mg/kg) altered the thermal stimulus response threshold used in the tail withdrawal test, thus indicating a possible central action presence. In the model of mechanical hypernociception induced by CFA, pre-treatment with the polysaccharide (27 and 81 mg/kg) inhibited CFA-induced hypernociception. Ratifying the specificity of the antinociceptive action, the polysaccharide (27 mg/kg) did not change the motor behavior of the animals in the rota rod and open field models. The structural characterization showed mannosyl residues involved in ?-3,6-type binding, suggesting that the sample is amannan. The results demonstrate that the polysaccharide has an efficient antinociceptive activity, indicating its development for the treatment of inflammatory pain conditions |
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2017 |
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2017-09-28 |
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2019-07-15T22:15:33Z |
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FERRAZ, Fl?via Menezes. Avalia??o do potencial antinociceptivo do polissacar?deo obtido a partir da levedura Rhodotorulaoryzicola. 2017. 64f. Disserta??o (Mestrado Acad?mico em Biotecnologia) - Universidade Estadual de Feira de Santana, Feira de Santana, 2017. |
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http://tede2.uefs.br:8080/handle/tede/793 |
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FERRAZ, Fl?via Menezes. Avalia??o do potencial antinociceptivo do polissacar?deo obtido a partir da levedura Rhodotorulaoryzicola. 2017. 64f. Disserta??o (Mestrado Acad?mico em Biotecnologia) - Universidade Estadual de Feira de Santana, Feira de Santana, 2017. |
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