Estudo de compatibilidade entre cafeína, dipirona e citrato de orfenadrina

• Ano de defesa: 2016
• Autor(a) principal: Alencar, Laianne Carla Batista
• Orientador(a): Medeiros, Ana Claudia Dantas de
• Banca de defesa: Pinto, Márcia Ferraz , Correia, Lidiane Pinto
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual da Paraíba
• Programa de Pós-Graduação: Programa de Pós-Graduação em Ciências Farmacêuticas - PPGCF
• Departamento: Pró-Reitoria de Pós-Graduação e Pesquisa - PRPGP
• País: BR
• Palavras-chave em Português: Compatibilidade química; Técnicas analíticas; Dipirona; Cafeína; Citrato de orfenadrina
• Palavras-chave em Inglês: Analytical techniques; Dipyrone; Caffeine; Orphenadrine citrate
• Área do conhecimento CNPq: CIENCIAS DA SAUDE
• Link de acesso: https://repositorio.uepb.edu.br/handle/123456789/73284

The development of a new pharmaceutical form involves a number of preliminary analyzes, which constitute the pre-formulation study, which will be gathered information about the physical, chemical and mechanical properties of the formulation constituents. Therefore, it is necessary to investigate the compatibility of active pharmaceutical ingredients and excipients of the final product by means of thermoanalytical and non-thermal techniques as possible interactions can alter and compromise the efficacy, safety and quality of the product. Therefore, the primary objective of this study is to assess the compatibility of the active pharmaceutical inputs dipyrone, and caffeine citrate orfenandrina each other and excipients. The differential scanning calorimetry (DSC) was performed in ratios of 2, 5 and 10 ° C / min^-1, coupled with differential thermal analysis (DTA), infrared spectroscopy (FTIR) and x-ray diffraction (XRD). All DSC curves were obtained melting points of the active pharmaceutical ingredients, especi ally the values of the melting point found in the heating rate of 2 ° C / min, which were 237.75 ° C, 222.36 ° C and 140 , 41 ° C for caffeine, dipyrone and orphenadrine citrate, respectively. While, in the cooling curves was not identified any polymorphism. The quaternary DTA curves evaluated aerosil selection at the expense of pregelatinized starch and microcrystalline cellulose 101. From the curves of the binary mixture, those containing dipyrone showed greater mismatch indication, whereas the mixtures of the active pharmaceutical ingredients from themselves were compatible, since the characteristic peaks thereof were identified without changing considerably, its thermal events. In the infrared spectra there is a chemical interaction of carboxymethylcellulose with caffeine, moreover, the spectra containing the binary mixtures dipyrone there was suppression on the free hydroxyl bands glycolate starch, carboxymethylcellulose, starch and croscarmellose sodium, a similar result occurred with the starch glycolate opposite orphenadrine citrate. The XRD patterns did not identify displacement or removal of significant robins to characterize some sort of incompatibility. Through evaluation by different analytical techniques across the various preparations, it was observed that the IFA may be sold simultaneously in view of their physical and chemical compatibility.