Relação dos resultados das corionariografias com o risco de exposição alimentar a desreguladores endócrinos

• Ano de defesa: 2018
• Autor(a) principal: Santos, Cristiane Pastor dos
• Orientador(a): Clapauch, Ruth
• Banca de defesa: Barbosa, Carolina Monteiro de Lemos , Collett-solberg, Paulo Ferrez , Guimarães, Marilia Martins
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade do Estado do Rio de Janeiro
• Programa de Pós-Graduação: Programa de Pós-Graduação em Fisiopatologia Clínica e Experimental
• Departamento: Centro Biomédico::Faculdade de Ciências Médicas
• País: BR
• Palavras-chave em Português: Bisfenol A; Ftalatos; Desreguladores endócrinos; Doença arterial coronariana; Calculadora Syntax score I; Cateterismo cardíaco; Fatores de risco; Alimentos Contaminação Aspectos endócrinos; Alimentos Contaminação Fatores de risco; Sistema cardiovascular Doenças Fatores de risco; Produtos químicos de desregulação endócrina Toxidade
• Palavras-chave em Inglês: Bisphenol A.; Phtalates; Endocrine disruptors; Coronary artery disease; Syntax score I; Cardiac catheterization; Risk factors
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::ENDOCRINOLOGIA
• Link de acesso: http://www.bdtd.uerj.br/handle/1/12715

Cardiovascular diseases are the main cause of death in Brazil, among them, the most prevalent is coronary artery disease (CAD). The Brazilian Society of Cardiology, describes some risk factors related to CAD, however new studies have shown that some compounds described as endocrine disrupters may be related to CAD and the most studied of them is Bisphenol A and phthalates. Through the questionnaire dietary risk diet for exposure to endocrine disrupters, it is possible to infer a contamination by endocrine disrupters.One of the exams that diagnose CAD is the cardiac catheterization, which is evaluated by the Syntax score I. The Syntax score is a validated quantitative evaluation algorithm that estimates the extent of coronary artery disease, with the purpose of suggesting the ideal treatment for each patient. To correlate the risk of food exposure to endocrine disrupters, through the dietary risk questionnaire for exposure to endocrine disrupters,with coronary lesions evaluated by the Syntax score, in order to identify dietary risk factors for coronary lesions in men and women. This is an exploratory, analytical, case-control, field-based field survey with a qualitative data approach. The patients were recruited in Hemodynamic outpatient clinic of Pedro Ernesto University Hospital. In this study, 141 people, 60 controls (35 women and 25 men) and 81 cases (24 women and 57 men) were investigated. Analysis of the data was performed with a description of the demographic characteristics and cardiovascular and proxys variables for endocrine disrupters and their relationship with coronary lesions. The group consisted of 141 subjects for the study. Regarding the outcome of coronary disease assessed by the Syntax Score, 42.6% of the patients comprised the Control group, without coronary lesion. In the Cases group, the lesions of low complexity were predominant 46.1%, followed by those of intermediate complexity with 7.1% and 4.3% of high complexity. This study showed that, based on the response to the dietary risk questionnaire for exposure to endocrine disrupters, the use of plastic bags and film paper in the study population was quite prevalent. Individuals who used film paper (PVC) were 2.08 fold more likely to present coronary lesions when compared to those who did not use film paper and those who used plastic bags presented 2.43 fold more risk for coronary lesion when compared to those who did not use plastic bags.