Aspectos estruturais e ultraestruturais da zona glomerulosa da glândula adrenal de ratos com hipertensão renovascular tratados com alisquireno

• Ano de defesa: 2016
• Autor(a) principal: Matos, Verônica Soares de
• Orientador(a): Carvalho, Jorge José de
• Banca de defesa: Faria, Suzana Côrte-real , Matsuura, Cristiane , Rocha, Vinícius Novaes
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade do Estado do Rio de Janeiro
• Programa de Pós-Graduação: Programa de Pós-Graduação em Fisiopatologia Clínica e Experimental
• Departamento: Centro Biomédico::Faculdade de Ciências Médicas
• País: BR
• Palavras-chave em Português: Glândula Adrenal; Zona glomerulosa; Aldosterona; Sistema Renina Angiotensina aldosterona; 2R1C; Alisquireno; Agentes hipotensivos Uso terapêutico; Hipertensão Tratamento; Sistema renina-angiotensina; Glândulas suprarrenais; Anti-hipertensivos; Zona Glomerulosa
• Palavras-chave em Inglês: Adrenal Gland; Glomerulosa zone; Aldosterone; Renin Angiotensin aldosterone System; 2K1C; Aliskiren
• Área do conhecimento CNPq: CNPQ::CIENCIAS BIOLOGICAS::MORFOLOGIA
• Link de acesso: http://www.bdtd.uerj.br/handle/1/12784

Hypertension is considered to be one of the risk factors for developing cardiovascular diseases. This pathology is manifested not only as an elevation of blood pressure, but also involves structural and functional changes of target organs, causing, for example, left ventricular hypertrophy and development of kidney disease. Can be classified as primary (essential), no cause attributable, or secondary, which is a result of an identifiable cause. Renal artery stenosis is the most common cause of this type of hypertension. The model two kidneys one clip (2K1C) resembles the renovascular hypertension in humans, showing hyperactivity of the Renin angiotensin aldosterone (RAAS). The adrenal glands are one of the major homeostatic organs of mammals, are formed by two distinct and endocrine organs consist of a cortex and an inner Medulla coated by a capsule composed of collagen, fibroblasts, elastic fibers and some smooth muscle fibers. The Mineralocorticoid aldosterone is secreted by adrenal glands, governed by the RAAS and acts in target organs such as heart, blood vessels and kidneys in order to keep track of blood volume, electrolyte balance and blood pressure (BP). Recent studies enhance the action of aldosterone as key hormone in the development of the hypertension. The RAAS is a hormonal cascade that through its multiple interactions contributes to cardiovascular homeostasis, additionally regulates also the endothelium response to inflammation. Excessive or activation of this deregulation has been recognized as an element of importance in the pathogenesis of cardiovascular, renal diseases and hypertension. The aliskiren is a direct blocker of RAAS, decreasing the activity of Renin and plasma concentration of angiotensin II and aldosterone inhibition. Several studies are underway to assess the effectiveness of aliskiren on protection of target organs. In this work, we evaluated the effects of structural and ultrastructural alisquireno of the zone glomerulosa of the adrenal gland of rats 2K1C. PCNA expression was evaluated, as well as Bax/Bcl2 and AT1 by imunoperoxidade. Through transmission electron microscopy observed ultrastructural changes in organelles in animals 2K1C. It was observed that the aliskiren was able to reduce the BP and minimize structural and ultrastructural damage in the zona glomerulosa.