Obtenção, caracterização e avaliação farmacológica de derivados dos monoterpenos carvacrol e timol

• Ano de defesa: 2017
• Autor(a) principal: Mesquita, Bruna Marques de
• Orientador(a): Lemos, Telma Leda Gomes de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Derivados; Carvacrol; Timol; Acetilcolinesterase; Larvicida
• Link de acesso: http://www.repositorio.ufc.br/handle/riufc/27555

Based on the vast literature on the therapeutic properties of the monoterpenes carvacrol and thymol, these compounds were used to obtain derivatives and the pharmacological activities of them were evaluated. Modifications were made to the hydroxyl group of C-1, obtaining eighteen derivatives of carvacrol (1a-1i) and thymol (2a-2i), with satisfactory yields. The structures were confirmed by spectroscopic methods, such as GC/MS, IR, 1H and 13C NMR. The compounds obtained and their precursors were submitted to an inhibition test of the acetylcholinesterase enzyme using the colorimetric method in which derivatives 1b and 2b showed positive results against the enzyme. Their cytotoxic activity in vitro were evaluated against SF295 (glioblastoma), HCT116 (colon - human) and PC3 (prostate) cells by the MTT method. Results showed weak cytoxiticy activity and also larvicidal activity to larvae of Aedes aegypti in the third stage, presenting significant results for derivatives 1a, 1b, 1c, 1h, 2a, 2b, 2c and 2h.