Fitoquímica e atividade antimicrobiana de Campomanesia adamantium (Cambess.) O. Berg (Myrtaceae)

• Ano de defesa: 2014
• Autor(a) principal: Sá, Stone de
• Orientador(a): Paula, José Realino de
• Banca de defesa: Paula, José Realino de, Santos, Pierre Alexandre dos, Morais, Sandra Ribeiro
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso embargado
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Programa de Pós-graduação em Ciências Farmacêuticas (FF)
• Departamento: Faculdade de Farmácia - FF (RMG)
• País: Brasil
• Palavras-chave em Português: Ácido valoneico; Estictano-3,22-diol; Prospecção fitoquímica; Microdiluição em caldo; Plantas do cerrado; Concentração inibitória mínima
• Palavras-chave em Inglês: Broth microdilution; Medicinal plants; MIC; Brazilian Savanna; Valoneic acid; Sticnano-2,3-diol
• Área do conhecimento CNPq: CIENCIAS DA SAUDE::FARMACIA
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tede/13902

Campomanesia adamantium (Cambess.) O. Berg is a native fruit species of the Cerrado biome, belonging to the Myrtaceae family, popularly known as guabiroba-do campo. Pharmacological studies and popular use of the plant indicate great antimicrobial potential. The present study aimed to phytochemical screening of the species, and to evaluate the antimicrobial profile. In phytochemical screening were used chromatographic and spectrometric techniques and for antimicrobial activity, microdilution test broth. It was possible to evaluate chemical composition and percent yield of the essential oil of leaves and flowers Campomanesia adamantium and volatile terpene compounds of the hexane fraction. In addition, novel compounds were identified in species such as estictano-3,22-diol, hydrolyzable tannins precursors such as gallic acid and valoneico acid. The phytochemicals results contribute to the scientific validation of etnomedicinal use of the species also add phytochemical information that cooperate for the study of genus. To evaluate the antimicrobial activity test was used microdilution broth, which allowed to determine the minimum inhibitory concentration (MIC) against strains of Gram positive and Gram negative bacteria and fungi Evaluation of the antimicrobial activity of C. adamantium, obtained in the present study revealed great potential antibibacteriano (hexane fraction) and antifungal (aqueous fraction, concentrated aqueous fraction of tannins and the compound isolated vanoleico acid). The isolated valoneico acid contributes to the antifungal activity of the extract.