Análise de fatores preditivos para tumorigenese no câncer de pulmão
Ano de defesa: | 2013 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | |
Tipo de documento: | Dissertação |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Mato Grosso
Brasil Faculdade de Medicina (FM) UFMT CUC - Cuiabá Programa de Pós-Graduação em Ciências da Saúde |
Programa de Pós-Graduação: |
Não Informado pela instituição
|
Departamento: |
Não Informado pela instituição
|
País: |
Não Informado pela instituição
|
Palavras-chave em Português: | |
Link de acesso: | http://ri.ufmt.br/handle/1/1630 |
Resumo: | The aim of this study was to evaluate the expression of biological markers (p53, ANXA1, EGFR, VEGF) in lung cancer patients: large cell carcinoma, squamous cell carcinoma and adenocarcinoma. Compared the control tissue with cancer cells, stronger staining of ANXA1 was observed in adenocarcinoma, squamous cell carcinoma and large-cell carcinoma. The analysis in ANXA1 posttranslation modification in lung cancer indicated that ANXA1-serine27- phosphorylation immunostaining in large-cell carcinoma was similar to control tissue, but was increased adenocarcinoma and squamous cell carcinoma. However, ANXA1-tyrosine21-phosphorylation immunoreactivity was detected with higher levels in the adenocarcinoma and squamous cell carcinoma and it was intensely detected I large-cell carcinoma. In the VEGF expression, it was significantly higher in adenocarcinoma, squamous cell carcinoma and large-cell carcinoma when compared with control tissue. About the p53, a stepwise increment of expression was found in the adenocarcinoma cells when compared to control tissue. A moderate to intense expression of p53 was shown to have a statistical significant increase in squamous cell carcinoma and large cell carcinoma. Finaly, EGFR immunohistochemical expression was significantly higher in cancer cells when compared with control tissue. In conclusion, we have identified potential candidates for biomarkers in lung adenocarcinoma, squamous cell carcinoma and large cell carcinoma. The proteins: ANXA1, EGFR, VEGF and p53 were found to be differentially expressed among lung cancer tissue. Also, the ANXA1 Tyr21 phosphorylation showed a closed relation with EGFR expression, which according to previous studies indicates an important mechanism in cell proliferation and differentiation. The correlation of those proteins during cell carcinogenesis need to be further validated. The present findings suggested that those proteins might be reliable biomarkers for prognosis of lung cancer. Our results reported here, combined with future studies, could have clinical value in predicting the prognosis of lung cancer, and identifying lung cancer patients that are at high risk of progression. |
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Análise de fatores preditivos para tumorigenese no câncer de pulmãoCâncer de pulmãop53anexina-A1VEGFEGFRCNPQ::CIENCIAS DA SAUDE::MEDICINALung câncerp53annexin-A1VEGFEGFR.The aim of this study was to evaluate the expression of biological markers (p53, ANXA1, EGFR, VEGF) in lung cancer patients: large cell carcinoma, squamous cell carcinoma and adenocarcinoma. Compared the control tissue with cancer cells, stronger staining of ANXA1 was observed in adenocarcinoma, squamous cell carcinoma and large-cell carcinoma. The analysis in ANXA1 posttranslation modification in lung cancer indicated that ANXA1-serine27- phosphorylation immunostaining in large-cell carcinoma was similar to control tissue, but was increased adenocarcinoma and squamous cell carcinoma. However, ANXA1-tyrosine21-phosphorylation immunoreactivity was detected with higher levels in the adenocarcinoma and squamous cell carcinoma and it was intensely detected I large-cell carcinoma. In the VEGF expression, it was significantly higher in adenocarcinoma, squamous cell carcinoma and large-cell carcinoma when compared with control tissue. About the p53, a stepwise increment of expression was found in the adenocarcinoma cells when compared to control tissue. A moderate to intense expression of p53 was shown to have a statistical significant increase in squamous cell carcinoma and large cell carcinoma. Finaly, EGFR immunohistochemical expression was significantly higher in cancer cells when compared with control tissue. In conclusion, we have identified potential candidates for biomarkers in lung adenocarcinoma, squamous cell carcinoma and large cell carcinoma. The proteins: ANXA1, EGFR, VEGF and p53 were found to be differentially expressed among lung cancer tissue. Also, the ANXA1 Tyr21 phosphorylation showed a closed relation with EGFR expression, which according to previous studies indicates an important mechanism in cell proliferation and differentiation. The correlation of those proteins during cell carcinogenesis need to be further validated. The present findings suggested that those proteins might be reliable biomarkers for prognosis of lung cancer. Our results reported here, combined with future studies, could have clinical value in predicting the prognosis of lung cancer, and identifying lung cancer patients that are at high risk of progression.FAPEMATO objetivo desse trabalho foi avaliar a expressão dos marcadores biológicos (p53, ANXA1, EGFR, VEGF) em pacientes com câncer pulmonar: carcinoma de células grandes, carcinoma epidermóide e adenocarcinoma. Em comparação com o tecido de controle de células cancerosas, com coloração mais forte do ANXA1 foi observada no adenocarcinoma, carcinoma de células epidermóide e carcinoma de células grandes. A análise ANXA1 modificação pós-tradução em câncer de pulmão indicou que imunofluorescência em ANXA1-serina 27 fosforilada em carcinoma de células grandes foi semelhante ao tecido controle, mas foi aumentado no adenocarcinoma e no carcinoma de células epidermóide. No entanto, imuno-ANXA1-tyrosina 21 fosforilada foi detectado com níveis mais elevados no adenocarcinoma e no carcinoma de células epidermóide e foi intensamente detectado no carcinoma de células grandes. Na expressão de VEGF, que era significativamente mais elevada no adenocarcinoma, carcinoma de células epidermóide e carcinoma de células grandes, quando comparados ao tecido controle. Sobre o p53, um aumento gradual de expressão foi encontrado nas células de adenocarcinoma, quando comparado com o tecido controle. A expressão moderada a intensa de p53 mostrou ter um aumento estatisticamente significativo no carcinoma epidermóide e carcinoma de células grandes. Finalmente, expressão EGFR de imunofluorescência foi significativamente maior nas células do câncer, quando comparado com o tecido controle. Nós identificamos potenciais candidatos para biomarcadores em ADC, CEC e LCC. As proteínas ANXA1, EGFR, VEGF e p53 foram observadas diferencialmente expressas entre os diferentes cânceres de pulmão. Além disso, a fosforilação ANXA1-Tyr21 mostrou uma estreita relação com a expressão do EGFR, o que de acordo com estudos anteriores indicam um mecanismo importante na proliferação e diferenciação celular. A correlação das proteínas durante a carcinogênese tem a necessidade de continuar a ser validado. Os achados sugerem que essas proteínas podem ser biomarcadores confiáveis para o prognóstico do câncer de pulmão. O resultado relatado aqui, combinado com estudos futuros, poderia ter valor clínico em predizer o prognóstico do câncer de pulmão, e identificação de pacientes com câncer de pulmão que estão em alto risco de progressão.Universidade Federal de Mato GrossoBrasilFaculdade de Medicina (FM)UFMT CUC - CuiabáPrograma de Pós-Graduação em Ciências da SaúdeDamazo, Amílcar Sabinohttp://lattes.cnpq.br/3708368867452889Damazo, Amílcar Sabino165.559.138-00http://lattes.cnpq.br/3708368867452889Crotti, Pedro Luis Reis165.559.138-00http://lattes.cnpq.br/2929183762019296165.559.138-00Sampaio, André Luiz Franco028.042.357-85http://lattes.cnpq.br/9141932858980243Custodio, Maria Angélica Damazo2019-11-28T15:26:18Z2013-11-262019-11-28T15:26:18Z2013-11-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisCUSTÓDIO, Maria Angélica Damazo. Análise de fatores preditivos para tumorigenese no câncer de pulmão. 2013. 55 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Mato Grosso, Faculdade de Medicina, Cuiabá, 2013.http://ri.ufmt.br/handle/1/1630porinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMTinstname:Universidade Federal de Mato Grosso (UFMT)instacron:UFMT2019-12-08T06:02:12Zoai:localhost:1/1630Repositório InstitucionalPUBhttp://ri.ufmt.br/oai/requestjordanbiblio@gmail.comopendoar:2019-12-08T06:02:12Repositório Institucional da UFMT - Universidade Federal de Mato Grosso (UFMT)false |
dc.title.none.fl_str_mv |
Análise de fatores preditivos para tumorigenese no câncer de pulmão |
title |
Análise de fatores preditivos para tumorigenese no câncer de pulmão |
spellingShingle |
Análise de fatores preditivos para tumorigenese no câncer de pulmão Custodio, Maria Angélica Damazo Câncer de pulmão p53 anexina-A1 VEGF EGFR CNPQ::CIENCIAS DA SAUDE::MEDICINA Lung câncer p53 annexin-A1 VEGF EGFR. |
title_short |
Análise de fatores preditivos para tumorigenese no câncer de pulmão |
title_full |
Análise de fatores preditivos para tumorigenese no câncer de pulmão |
title_fullStr |
Análise de fatores preditivos para tumorigenese no câncer de pulmão |
title_full_unstemmed |
Análise de fatores preditivos para tumorigenese no câncer de pulmão |
title_sort |
Análise de fatores preditivos para tumorigenese no câncer de pulmão |
author |
Custodio, Maria Angélica Damazo |
author_facet |
Custodio, Maria Angélica Damazo |
author_role |
author |
dc.contributor.none.fl_str_mv |
Damazo, Amílcar Sabino http://lattes.cnpq.br/3708368867452889 Damazo, Amílcar Sabino 165.559.138-00 http://lattes.cnpq.br/3708368867452889 Crotti, Pedro Luis Reis 165.559.138-00 http://lattes.cnpq.br/2929183762019296 165.559.138-00 Sampaio, André Luiz Franco 028.042.357-85 http://lattes.cnpq.br/9141932858980243 |
dc.contributor.author.fl_str_mv |
Custodio, Maria Angélica Damazo |
dc.subject.por.fl_str_mv |
Câncer de pulmão p53 anexina-A1 VEGF EGFR CNPQ::CIENCIAS DA SAUDE::MEDICINA Lung câncer p53 annexin-A1 VEGF EGFR. |
topic |
Câncer de pulmão p53 anexina-A1 VEGF EGFR CNPQ::CIENCIAS DA SAUDE::MEDICINA Lung câncer p53 annexin-A1 VEGF EGFR. |
description |
The aim of this study was to evaluate the expression of biological markers (p53, ANXA1, EGFR, VEGF) in lung cancer patients: large cell carcinoma, squamous cell carcinoma and adenocarcinoma. Compared the control tissue with cancer cells, stronger staining of ANXA1 was observed in adenocarcinoma, squamous cell carcinoma and large-cell carcinoma. The analysis in ANXA1 posttranslation modification in lung cancer indicated that ANXA1-serine27- phosphorylation immunostaining in large-cell carcinoma was similar to control tissue, but was increased adenocarcinoma and squamous cell carcinoma. However, ANXA1-tyrosine21-phosphorylation immunoreactivity was detected with higher levels in the adenocarcinoma and squamous cell carcinoma and it was intensely detected I large-cell carcinoma. In the VEGF expression, it was significantly higher in adenocarcinoma, squamous cell carcinoma and large-cell carcinoma when compared with control tissue. About the p53, a stepwise increment of expression was found in the adenocarcinoma cells when compared to control tissue. A moderate to intense expression of p53 was shown to have a statistical significant increase in squamous cell carcinoma and large cell carcinoma. Finaly, EGFR immunohistochemical expression was significantly higher in cancer cells when compared with control tissue. In conclusion, we have identified potential candidates for biomarkers in lung adenocarcinoma, squamous cell carcinoma and large cell carcinoma. The proteins: ANXA1, EGFR, VEGF and p53 were found to be differentially expressed among lung cancer tissue. Also, the ANXA1 Tyr21 phosphorylation showed a closed relation with EGFR expression, which according to previous studies indicates an important mechanism in cell proliferation and differentiation. The correlation of those proteins during cell carcinogenesis need to be further validated. The present findings suggested that those proteins might be reliable biomarkers for prognosis of lung cancer. Our results reported here, combined with future studies, could have clinical value in predicting the prognosis of lung cancer, and identifying lung cancer patients that are at high risk of progression. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-11-26 2013-11-22 2019-11-28T15:26:18Z 2019-11-28T15:26:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
CUSTÓDIO, Maria Angélica Damazo. Análise de fatores preditivos para tumorigenese no câncer de pulmão. 2013. 55 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Mato Grosso, Faculdade de Medicina, Cuiabá, 2013. http://ri.ufmt.br/handle/1/1630 |
identifier_str_mv |
CUSTÓDIO, Maria Angélica Damazo. Análise de fatores preditivos para tumorigenese no câncer de pulmão. 2013. 55 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Mato Grosso, Faculdade de Medicina, Cuiabá, 2013. |
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http://ri.ufmt.br/handle/1/1630 |
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openAccess |
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Universidade Federal de Mato Grosso Brasil Faculdade de Medicina (FM) UFMT CUC - Cuiabá Programa de Pós-Graduação em Ciências da Saúde |
publisher.none.fl_str_mv |
Universidade Federal de Mato Grosso Brasil Faculdade de Medicina (FM) UFMT CUC - Cuiabá Programa de Pós-Graduação em Ciências da Saúde |
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reponame:Repositório Institucional da UFMT instname:Universidade Federal de Mato Grosso (UFMT) instacron:UFMT |
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Repositório Institucional da UFMT - Universidade Federal de Mato Grosso (UFMT) |
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jordanbiblio@gmail.com |
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