A influência da síndrome dos ovários policísticos nos aspectos imunes celular e humoral

• Ano de defesa: 2017
• Autor(a) principal: Santos, Jacqueliny Conceição Lima
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Mato Grosso; Brasil; Faculdade de Medicina (FM); UFMT CUC - Cuiabá; Programa de Pós-Graduação em Ciências da Saúde
• Palavras-chave em Português: Imunidade; Síndrome do ovário policístico; Citocinas; CNPQ::CIENCIAS DA SAUDE; Immunity; Polycystic ovarian syndrome; Cytokines
• Link de acesso: http://ri.ufmt.br/handle/1/4157

Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women of reproductive age. It has a diversity of phenotypes, however, it is known that women with PCOS have polycystic ovaries, chronic anovulation, hyperandrogenism and gonadotrophin abnormalities. In addition to also exhibiting metabolic and endocrine abnormalities that are associated with obesity, type 2 diabetes and dyslipidemia. This variety of clinical and metabolic aspects in PCOS can lead to the risk of developing cardiovascular diseases, as well as the occurrence of low-grade chronic inflammation, often seen in PCOS, which may be associated with insulin resistance and obesity. This inflammatory process leads to the action of the immune system, resulting in the secretion of proinflammatory cytokines such as Interferon gamma (INF- γ) and anti-inflammatory cytokines such as interleukin 4 (IL4) and immunoglobulins IgA, IgG, IgD, IgE and IgM present in the blood, called antibodies, produced and secreted by the accumulation of visceral fat. Knowing the mechanisms of the chronic inflammatory process in women with PCOS can enable a better understanding of the disease, as well as the prevention of the clinical and metabolic consequences of the syndrome. Thus, this study seeks to understand how these cells of the immune system act in the syndrome, seeking a better understanding of how this inflammatory process happens.