Contribuição ao Conhecimento de Erythrina velutina Willd. (Fabaceae-Faboideae): Uma abordagem Farmacobotânica, Química e Farmacologica.

• Ano de defesa: 2011
• Autor(a) principal: Melo, Ingrid Christie Alexandrino Ribeiro de
• Orientador(a): Agra, Maria de Fátima
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal da Paraí­ba
• Programa de Pós-Graduação: Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos
• Departamento: Farmacologia
• País: BR
• Palavras-chave em Português: Erythrina velutina; Mulungu; Ansiedade; Sedação; Alcalóides
• Palavras-chave em Inglês: Erythrina velutina; Mulungu; Anxiety; Sedation; Alkaloids
• Área do conhecimento CNPq: CIENCIAS BIOLOGICAS::FARMACOLOGIA
• Link de acesso: https://repositorio.ufpb.br/jspui/handle/tede/6869

Erythrina velutina Willd., is a plant species native to the caatinga of northeastern Brazil, known popularly as ―mulungu‖. Its leaves are used as a decoction in folk medicine as a remedy for anxiety and as a sedative. The aim of this work was to perform an interdisciplinary study of the species, combining a pharmacobotanical, chemical and pharmacological approach to investigate the basis of its popular use in folk medicine. Morphological and morphodiagnosis studies were performed to estabilish the identity of the species. For anatomical characterization cross section preparations of the blade, petiole and petiolule were performed as well as paradermic preparations on both sides of the blade leaflets. The sections were cleared, stained with safranin and/or safrablue, observed and photographed under an optical microscope. The pharmacological study involved the selection of extracts from the bark and leaves with CNS depressant pharmacological profile using a behavioural screening and further pharmacological tests with emphasis on evaluation of the anxiolytic/sedative activity. To chemically characterize the active methanolic fraction (Fr.MeOH) obtained from the aqueous extract of the leaves, theusing Amberlite XAD-2® further fractionation and preparative purification was done using HPLC and spectroscopicl analysis by 1H and 13C NMR. The pharmacobotanical study showed the presence of distinctive parameters for Erythrina velutina, easily identifiable, and of great importance to its quality control. The pharmacological profile of Fr.MeOH is characteristic of drugs sedative and its chemical characterization revealed the presence of alkaloids that are probably responsible for the sedative effects observed in pharmacological tests of this study.