Influ?ncia do volume de uma formula??o pour-on de fipronil na efic?cia sobre Ctenocephalides felis felis e Rhipicephalus sanguineus em c?es

Detalhes bibliográficos
Ano de defesa: 2014
Autor(a) principal: Silva, Diego Dias da lattes
Orientador(a): Scott, Fabio Barbour lattes
Banca de defesa: Martins, Isabela Vilhena Freire, Fernandes, Julio Israel
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal Rural do Rio de Janeiro
Programa de Pós-Graduação: Programa de P?s-Gradua??o em Ci?ncias Veterin?rias
Departamento: Instituto de Veterin?ria
País: Brasil
Palavras-chave em Português:
Fenilpirazole
Volume
Efic?cia
Palavras-chave em Inglês:
Phenylpyrazole
Efficacy
Área do conhecimento CNPq:
Medicina Veterin?ria
Link de acesso: https://tede.ufrrj.br/jspui/handle/jspui/2882
Resumo: Given the relationship between various components of a formulation can positively or negatively interfere with the action of the active ingredient, the present study aimed to evaluate the influence of the volume of pour-on formulation containing fipronil used in dogs, maintaining the recommended dose of active ingredient, on the effectiveness against Ctenocephalides felis felis and Rhipicephalus sanguineus. For this purpose, 24 dogs were divided into four groups: control, which remained untreated, and treated groups A, B and C, medicated with 1.34 mL, 2.68 mL and 5.36 mL of a topical solution containing 10.7%, 5.3% and 1.8% fipronil, respectively. Each dog was infested two days before treatment and weekly after that with 100 samples of non-fed adult C. f. felis and 50 non-fed adults of R. sanguineus, keeping for both, equal sex ratio. The evaluation of immediate efficacy occurred two days after treatment and residual efficacy assessments were performed weekly, always 48 hours after each infestation. To this purpose, was proceeded the removal and counting of fleas and ticks, by manual grooming and/or by comb- test method, and the calculation of the efficacy made by Abbott?s formula. The group treated with 5.36 mL of 1.8% fipronil solution showed efficacy against R. sanguineus greater than 90% for 28 days, higher than groups treated with 1.34 mL and 2.68 mL of 10,7% and 5,3% fipronil solutions, which presented protection against re-infestation for 21 days period. In the two subsequent weekly assessments the highest volume remained superior to the others, although not reaching satisfactory levels of protection. Residual efficacy above 95% against C. f. felis was obtained up to 35 days by the three tested volumes. Despite fleacide efficacy less than 95% obtained in the 42? day after the treatment by all tested volumes, the 2.68 mL and 5.36 mL volumes were superior than 1.34 ml volume. It is concluded that the increased volume of topically solution of fipronil applied in dogs, maintaining the recommended dose of the active ingredient, increased its residual efficacy against C. f. felis and R. sanguineus, showing that simple changes in ectoparasiticide topical formulations may significantly modify the degree of protection provided
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spelling Scott, Fabio Barbour001.382.167-97http://lattes.cnpq.br/1217253540572819Azevedo, Tha?s Ribeiro Correia086.063.187-79http://lattes.cnpq.br/6049103053269712Martins, Isabela Vilhena FreireFernandes, Julio Israel112.713.937-19http://lattes.cnpq.br/0795462260494202Silva, Diego Dias da2019-09-11T13:16:21Z2014-02-28SILVA, Diego Dias da. Influ?ncia do volume de uma formula??o pour-on de fipronil na efic?cia sobre Ctenocephalides felis felis e Rhipicephalus sanguineus em c?es. 2014. 47 f. Disserta??o (Programa de P?s-Gradua??o em Ci?ncias Veterin?rias) - Universidade Federal Rural do Rio de Janeiro, Serop?dica.https://tede.ufrrj.br/jspui/handle/jspui/2882Given the relationship between various components of a formulation can positively or negatively interfere with the action of the active ingredient, the present study aimed to evaluate the influence of the volume of pour-on formulation containing fipronil used in dogs, maintaining the recommended dose of active ingredient, on the effectiveness against Ctenocephalides felis felis and Rhipicephalus sanguineus. For this purpose, 24 dogs were divided into four groups: control, which remained untreated, and treated groups A, B and C, medicated with 1.34 mL, 2.68 mL and 5.36 mL of a topical solution containing 10.7%, 5.3% and 1.8% fipronil, respectively. Each dog was infested two days before treatment and weekly after that with 100 samples of non-fed adult C. f. felis and 50 non-fed adults of R. sanguineus, keeping for both, equal sex ratio. The evaluation of immediate efficacy occurred two days after treatment and residual efficacy assessments were performed weekly, always 48 hours after each infestation. To this purpose, was proceeded the removal and counting of fleas and ticks, by manual grooming and/or by comb- test method, and the calculation of the efficacy made by Abbott?s formula. The group treated with 5.36 mL of 1.8% fipronil solution showed efficacy against R. sanguineus greater than 90% for 28 days, higher than groups treated with 1.34 mL and 2.68 mL of 10,7% and 5,3% fipronil solutions, which presented protection against re-infestation for 21 days period. In the two subsequent weekly assessments the highest volume remained superior to the others, although not reaching satisfactory levels of protection. Residual efficacy above 95% against C. f. felis was obtained up to 35 days by the three tested volumes. Despite fleacide efficacy less than 95% obtained in the 42? day after the treatment by all tested volumes, the 2.68 mL and 5.36 mL volumes were superior than 1.34 ml volume. It is concluded that the increased volume of topically solution of fipronil applied in dogs, maintaining the recommended dose of the active ingredient, increased its residual efficacy against C. f. felis and R. sanguineus, showing that simple changes in ectoparasiticide topical formulations may significantly modify the degree of protection providedTendo em vista que a rela??o entre diversos componentes de uma formula??o pode interferir positiva ou negativamente na a??o do princ?pio ativo, o presente trabalho teve por objetivo avaliar a influ?ncia do volume de formula??o pour-on contendo fipronil empregado em c?es, mantendo-se a dose preconizada do princ?pio ativo, sobre a efic?cia contra Ctenocephalides felis felis e Rhipicephalus sanguineus. Para isso, foram utilizados 24 c?es divididos em quatro grupos: controle, o qual permaneceu sem tratamento, e os grupos tratados A, B e C, medicados com 1,34mL, 2,68mL e 5,36mL de solu??o contendo 10,7%, 5,3% e 1,8% de fipronil, respectivamente. Cada c?o foi infestado dois dias antes do tratamento e semanalmente ap?s o mesmo com 100 exemplares adultos n?o alimentados de C. f. felis e 50 adultos n?o alimentados de R. sanguineus, mantendo-se, para ambos, igual propor??o entre os sexos. A avalia??o de efic?cia imediata ocorreu dois ap?s o tratamento e as avalia??es de efic?cia residual foram realizadas semanalmente, sempre 48 horas ap?s as infesta??es. Para tal, procedeu-se a retirada e contagem das pulgas e carrapatos, por cata??o manual e/ou m?todo ?comb-test? e os c?lculos de efic?cia efetuados pela da f?rmula de Abbott. O grupo tratado com 5,36mL de solu??o de fipronil apresentou efic?cia contra R. sanguineus superior a 90% por 28 dias, sendo superior aos grupos medicados com 1,34mL e 2,68mL, os quais apresentaram-se protegidos contra reinfesta??es por um per?odo de 21 dias. Nas duas avalia??es semanais subsequentes o maior volume manteve-se superior aos demais, mesmo n?o atingindo n?veis satisfat?rios de prote??o. Efic?cia residual acima de 95% contra C. f. felis foi obtida por at? 35 dias pelos tr?s volumes testados. Apesar das efic?cias pulguicidas inferiores a 95% obtidas no quadrag?simo segundo dia ap?s o tratamento, os volumes de 2,68mL e 5,36mL apresentaram-se superiores ao volume de 1,34mL. Conclui-se, portanto, que o aumento do volume aplicado de solu??o pour-on de fipronil em c?es, mantendo-se a dose preconizada do princ?pio ativo, elevou significativamente sua efic?cia residual contra C. f. felis e R. sanguineus, evidenciando que simples altera??es nas formula??es ectoparasiticidas t?picas podem alterar de forma significativa o grau de prote??o fornecidoSubmitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2019-09-11T13:16:21Z No. of bitstreams: 1 2014 - Diego Dias da Silva.pdf: 2648378 bytes, checksum: 304a0f0bdc442763503a88e0245efc7d (MD5)Made available in DSpace on 2019-09-11T13:16:21Z (GMT). No. of bitstreams: 1 2014 - Diego Dias da Silva.pdf: 2648378 bytes, checksum: 304a0f0bdc442763503a88e0245efc7d (MD5) Previous issue date: 2014-02-28Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPQapplication/pdfhttps://tede.ufrrj.br/retrieve/10572/2014%20-%20Diego%20Dias%20da%20Silva.pdf.jpghttps://tede.ufrrj.br/retrieve/16358/2014%20-%20Diego%20Dias%20da%20Silva.pdf.jpghttps://tede.ufrrj.br/retrieve/22662/2014%20-%20Diego%20Dias%20da%20Silva.pdf.jpghttps://tede.ufrrj.br/retrieve/29042/2014%20-%20Diego%20Dias%20da%20Silva.pdf.jpghttps://tede.ufrrj.br/retrieve/35394/2014%20-%20Diego%20Dias%20da%20Silva.pdf.jpghttps://tede.ufrrj.br/retrieve/41790/2014%20-%20Diego%20Dias%20da%20Silva.pdf.jpghttps://tede.ufrrj.br/retrieve/48192/2014%20-%20Diego%20Dias%20da%20Silva.pdf.jpghttps://tede.ufrrj.br/retrieve/54644/2014%20-%20Diego%20Dias%20da%20Silva.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Ci?ncias Veterin?riasUFRRJBrasilInstituto de Veterin?riaAAJOUD, A.; RAVANEL, P.; TISSUT, M. 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dc.title.por.fl_str_mv Influ?ncia do volume de uma formula??o pour-on de fipronil na efic?cia sobre Ctenocephalides felis felis e Rhipicephalus sanguineus em c?es
dc.title.alternative.eng.fl_str_mv Influence of the volume of a pour-on formulation of fipronil on the effectiveness against Ctenocephalides felis felis and Rhipicephalus sanguineus in dogs
title Influ?ncia do volume de uma formula??o pour-on de fipronil na efic?cia sobre Ctenocephalides felis felis e Rhipicephalus sanguineus em c?es
spellingShingle Influ?ncia do volume de uma formula??o pour-on de fipronil na efic?cia sobre Ctenocephalides felis felis e Rhipicephalus sanguineus em c?es
Silva, Diego Dias da
Fenilpirazole
Volume
Efic?cia
Phenylpyrazole
Efficacy
Medicina Veterin?ria
title_short Influ?ncia do volume de uma formula??o pour-on de fipronil na efic?cia sobre Ctenocephalides felis felis e Rhipicephalus sanguineus em c?es
title_full Influ?ncia do volume de uma formula??o pour-on de fipronil na efic?cia sobre Ctenocephalides felis felis e Rhipicephalus sanguineus em c?es
title_fullStr Influ?ncia do volume de uma formula??o pour-on de fipronil na efic?cia sobre Ctenocephalides felis felis e Rhipicephalus sanguineus em c?es
title_full_unstemmed Influ?ncia do volume de uma formula??o pour-on de fipronil na efic?cia sobre Ctenocephalides felis felis e Rhipicephalus sanguineus em c?es
title_sort Influ?ncia do volume de uma formula??o pour-on de fipronil na efic?cia sobre Ctenocephalides felis felis e Rhipicephalus sanguineus em c?es
author Silva, Diego Dias da
author_facet Silva, Diego Dias da
author_role author
dc.contributor.advisor1.fl_str_mv Scott, Fabio Barbour
dc.contributor.advisor1ID.fl_str_mv 001.382.167-97
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/1217253540572819
dc.contributor.advisor-co1.fl_str_mv Azevedo, Tha?s Ribeiro Correia
dc.contributor.advisor-co1ID.fl_str_mv 086.063.187-79
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/6049103053269712
dc.contributor.referee1.fl_str_mv Martins, Isabela Vilhena Freire
dc.contributor.referee2.fl_str_mv Fernandes, Julio Israel
dc.contributor.authorID.fl_str_mv 112.713.937-19
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/0795462260494202
dc.contributor.author.fl_str_mv Silva, Diego Dias da
contributor_str_mv Scott, Fabio Barbour
Azevedo, Tha?s Ribeiro Correia
Martins, Isabela Vilhena Freire
Fernandes, Julio Israel
dc.subject.por.fl_str_mv Fenilpirazole
Volume
Efic?cia
topic Fenilpirazole
Volume
Efic?cia
Phenylpyrazole
Efficacy
Medicina Veterin?ria
dc.subject.eng.fl_str_mv Phenylpyrazole
Efficacy
dc.subject.cnpq.fl_str_mv Medicina Veterin?ria
description Given the relationship between various components of a formulation can positively or negatively interfere with the action of the active ingredient, the present study aimed to evaluate the influence of the volume of pour-on formulation containing fipronil used in dogs, maintaining the recommended dose of active ingredient, on the effectiveness against Ctenocephalides felis felis and Rhipicephalus sanguineus. For this purpose, 24 dogs were divided into four groups: control, which remained untreated, and treated groups A, B and C, medicated with 1.34 mL, 2.68 mL and 5.36 mL of a topical solution containing 10.7%, 5.3% and 1.8% fipronil, respectively. Each dog was infested two days before treatment and weekly after that with 100 samples of non-fed adult C. f. felis and 50 non-fed adults of R. sanguineus, keeping for both, equal sex ratio. The evaluation of immediate efficacy occurred two days after treatment and residual efficacy assessments were performed weekly, always 48 hours after each infestation. To this purpose, was proceeded the removal and counting of fleas and ticks, by manual grooming and/or by comb- test method, and the calculation of the efficacy made by Abbott?s formula. The group treated with 5.36 mL of 1.8% fipronil solution showed efficacy against R. sanguineus greater than 90% for 28 days, higher than groups treated with 1.34 mL and 2.68 mL of 10,7% and 5,3% fipronil solutions, which presented protection against re-infestation for 21 days period. In the two subsequent weekly assessments the highest volume remained superior to the others, although not reaching satisfactory levels of protection. Residual efficacy above 95% against C. f. felis was obtained up to 35 days by the three tested volumes. Despite fleacide efficacy less than 95% obtained in the 42? day after the treatment by all tested volumes, the 2.68 mL and 5.36 mL volumes were superior than 1.34 ml volume. It is concluded that the increased volume of topically solution of fipronil applied in dogs, maintaining the recommended dose of the active ingredient, increased its residual efficacy against C. f. felis and R. sanguineus, showing that simple changes in ectoparasiticide topical formulations may significantly modify the degree of protection provided
publishDate 2014
dc.date.issued.fl_str_mv 2014-02-28
dc.date.accessioned.fl_str_mv 2019-09-11T13:16:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Diego Dias da. Influ?ncia do volume de uma formula??o pour-on de fipronil na efic?cia sobre Ctenocephalides felis felis e Rhipicephalus sanguineus em c?es. 2014. 47 f. Disserta??o (Programa de P?s-Gradua??o em Ci?ncias Veterin?rias) - Universidade Federal Rural do Rio de Janeiro, Serop?dica.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/2882
identifier_str_mv SILVA, Diego Dias da. Influ?ncia do volume de uma formula??o pour-on de fipronil na efic?cia sobre Ctenocephalides felis felis e Rhipicephalus sanguineus em c?es. 2014. 47 f. Disserta??o (Programa de P?s-Gradua??o em Ci?ncias Veterin?rias) - Universidade Federal Rural do Rio de Janeiro, Serop?dica.
url https://tede.ufrrj.br/jspui/handle/jspui/2882
dc.language.iso.fl_str_mv por
language por
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