Avalia??o da curva de concentra??o plasm?tica e efic?cia da ivermectina oral em c?es contra Ctenocephalides felis felis e Rhipicephalus sanguineus

Detalhes bibliográficos
Ano de defesa: 2012
Autor(a) principal: Magalh?es, Viviane de Souza lattes
Orientador(a): Scott, Fabio Barbour lattes
Banca de defesa: Fernandes, Julio Israel, Gon?alves, Jos? Carlos Saraiva
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal Rural do Rio de Janeiro
Programa de Pós-Graduação: Programa de P?s-Gradua??o em Ci?ncias Veterin?rias
Departamento: Instituto de Veterin?ria
País: Brasil
Palavras-chave em Português:
macrolactonas,
farmacocin?tica
cromatografia l?quida
Palavras-chave em Inglês:
macrolactones, ,
pharmacokinetics
liquid chromatography
Área do conhecimento CNPq:
Medicina Veterin?ria
Link de acesso: https://tede.ufrrj.br/jspui/handle/jspui/3660
Resumo: getting closer and concern for the control of diseases increasing. This control is often performed with the use of chemicals known as insecticides. Among them, ivermectin is extremely widespread use because of its proven safety. Its use in dogs is suitable for the treatment of mite dermodicosi and heartworm prevention, but is extremely informally used for the control of fleas and ticks. Among the most common ectoparasites in dogs are the Rhipcephalus sanguineus tick and Ctenocephalides felis felis flea. In order to evaluate the efficacy of ivermectin against these parasites, along with treatment follow the profile of plasma tested formulation of ivermectin, a method was developed for quantification of ivermectin in canine plasma using liquid chromatography with fluorescence detection. This method was validated based on the recommendations of the National Agency of Sanitary Surveillance for validation of analytical methods and bioanalytical, Resolution RE n ? 899/2003. The samples collected during the test effectiveness using this method were analyzed and showed good bioavailability with Cmax 350 ng.mL-1 in four (4) hour and at AUC of 8411. Although the formulation have shown good absorption efficacy values found for Rhipcephalus sanguineus and Ctenocephalides felis felis were very low showing this is not the most appropriate treatment for the control of these parasites.
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spelling Scott, Fabio Barbourhttp://lattes.cnpq.br/1217253540572819Fernandes, Julio IsraelGon?alves, Jos? Carlos SaraivaCPF: 057.185.477-00http://lattes.cnpq.br/1129995417777144Magalh?es, Viviane de Souza2020-06-23T18:49:35Z2012-02-24MAGALH~ES, Viviane de Souza. Avalia??o da curva de concentra??o plasm?tica e efic?cia da ivermectina oral em c?es contra Ctenocephalides felis felis e Rhipicephalus sanguineus. 2012. 56 f. Disserta??o (Mestrado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2012.https://tede.ufrrj.br/jspui/handle/jspui/3660getting closer and concern for the control of diseases increasing. This control is often performed with the use of chemicals known as insecticides. Among them, ivermectin is extremely widespread use because of its proven safety. Its use in dogs is suitable for the treatment of mite dermodicosi and heartworm prevention, but is extremely informally used for the control of fleas and ticks. Among the most common ectoparasites in dogs are the Rhipcephalus sanguineus tick and Ctenocephalides felis felis flea. In order to evaluate the efficacy of ivermectin against these parasites, along with treatment follow the profile of plasma tested formulation of ivermectin, a method was developed for quantification of ivermectin in canine plasma using liquid chromatography with fluorescence detection. This method was validated based on the recommendations of the National Agency of Sanitary Surveillance for validation of analytical methods and bioanalytical, Resolution RE n ? 899/2003. The samples collected during the test effectiveness using this method were analyzed and showed good bioavailability with Cmax 350 ng.mL-1 in four (4) hour and at AUC of 8411. Although the formulation have shown good absorption efficacy values found for Rhipcephalus sanguineus and Ctenocephalides felis felis were very low showing this is not the most appropriate treatment for the control of these parasites.Com o aumento crescente de animais de companhia nos lares familiares o relacionamento humano-animal est? cada vez mais estreito e a preocupa??o com o controle de doen?as cada vez maior. Este controle muitas vezes ? realizado com a utiliza??o de produtos qu?micos, chamados de inseticidas. Entre os estes, a ivermectina tem seu uso extremamente difundido devido sua seguran?a comprovada. Seu uso em c?es ? aconselhado para o tratamento da sarna demod?cica e na preven??o da dirofilariose, por?m informalmente ? extremamente utilizado para o controle de pulgas e carrapatos. Entre os ectoparasitas mais comum nos c?es est?o o carrapato Rhipcephalus sanguineus e a pulga Ctenocephalides felis felis. Com o objetivo de avaliar a efic?cia da ivermectina contra esses parasitas e juntamente ao tratamento acompanhar o perfil plasm?tico da formula??o de ivermectina testada, foi desenvolvido um m?todo de quantifica??o de ivermectina em plasma canino, utilizando cromatografia l?quida com detec??o por fluoresc?ncia. Este m?todo foi validado tendo como base as recomenda??es da Ag?ncia Nacional de Vigil?ncia Sanit?ria para valida??o de m?todos anal?ticos e bional?ticos, a Resolu??o RE n?899, de 29 de maio de 2003. As amostras coletas durante o teste de efic?cia foram analisadas atrav?s deste m?todo e demonstraram boa biodisponibilidade com Cmax de 350 ng.mL-1 em quatro (4) horas e AUC de 8411. Apesar de a formula??o ter apresentado boa absor??o os valores de efic?cia encontrados para Rhipcephalus sanguineus e Ctenocephalides felis felis foram muito baixos demonstrando este n?o ser o tratamento mais adequado para o controle destes parasitas.Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2020-06-23T18:49:35Z No. of bitstreams: 1 2012 - Viviane de Souza Magalhaes.pdf: 714699 bytes, checksum: 8f75dd67146e550e9f353c43fe40fc0f (MD5)Made available in DSpace on 2020-06-23T18:49:35Z (GMT). No. of bitstreams: 1 2012 - Viviane de Souza Magalhaes.pdf: 714699 bytes, checksum: 8f75dd67146e550e9f353c43fe40fc0f (MD5) Previous issue date: 2012-02-24CNPq - Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gicoapplication/pdfhttps://tede.ufrrj.br/retrieve/60820/2012%20-%20Viviane%20de%20Souza%20Magalhaes.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Ci?ncias Veterin?riasUFRRJBrasilInstituto de Veterin?riaALVINERIE, M.; DUPUY, J.; EECKHOUTTE, C.; SUTRA, J. F. Enhanced absorption of pour-on ivermectin formulation in rats by co-administration of the multidrug-resistantreversing agent verapamil. Parasitology research, 11, 920-922, 1999. ANALFAPET. Associa??o Nacional de Fabricantes de Produtos para Animais de Estima??o ? 2009 Dispon?vel em: <https://www.s2publication.com.br/imprensa/Release TextoS2Publicom.aspx?press_release_id=22913>. Acesso em 25 de 02 de 2011. ANOV?, C. M.; HUTTA, M. 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Journal of occupational health psychology, 6, 81-87, 2001. ZAKSON-AIKEN, M.; GREGORY, L. M.; MEINKE, P. T.; SHOOP, W. L. Systemic activity of the avermectins against the cat flea (Siphonaptera: Pulicidae). Journal of Medical Entomology, 38, 576-580, 2001. 56 ZENNER, L.; DREVON-GAILLOT, E.; MARCY-L??TOILE. Combate qu?mico e controle dos carrapatos em c?es e gatos. 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dc.title.por.fl_str_mv Avalia??o da curva de concentra??o plasm?tica e efic?cia da ivermectina oral em c?es contra Ctenocephalides felis felis e Rhipicephalus sanguineus
dc.title.alternative.eng.fl_str_mv Evaluation of plasma concentration curve and efficacy of ivermectin following oral administration in dogs against Ctenocephalides felis felis and Rhipicephalus sanguineus
title Avalia??o da curva de concentra??o plasm?tica e efic?cia da ivermectina oral em c?es contra Ctenocephalides felis felis e Rhipicephalus sanguineus
spellingShingle Avalia??o da curva de concentra??o plasm?tica e efic?cia da ivermectina oral em c?es contra Ctenocephalides felis felis e Rhipicephalus sanguineus
Magalh?es, Viviane de Souza
macrolactonas,
farmacocin?tica
cromatografia l?quida
macrolactones, ,
pharmacokinetics
liquid chromatography
Medicina Veterin?ria
title_short Avalia??o da curva de concentra??o plasm?tica e efic?cia da ivermectina oral em c?es contra Ctenocephalides felis felis e Rhipicephalus sanguineus
title_full Avalia??o da curva de concentra??o plasm?tica e efic?cia da ivermectina oral em c?es contra Ctenocephalides felis felis e Rhipicephalus sanguineus
title_fullStr Avalia??o da curva de concentra??o plasm?tica e efic?cia da ivermectina oral em c?es contra Ctenocephalides felis felis e Rhipicephalus sanguineus
title_full_unstemmed Avalia??o da curva de concentra??o plasm?tica e efic?cia da ivermectina oral em c?es contra Ctenocephalides felis felis e Rhipicephalus sanguineus
title_sort Avalia??o da curva de concentra??o plasm?tica e efic?cia da ivermectina oral em c?es contra Ctenocephalides felis felis e Rhipicephalus sanguineus
author Magalh?es, Viviane de Souza
author_facet Magalh?es, Viviane de Souza
author_role author
dc.contributor.advisor1.fl_str_mv Scott, Fabio Barbour
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/1217253540572819
dc.contributor.referee1.fl_str_mv Fernandes, Julio Israel
dc.contributor.referee2.fl_str_mv Gon?alves, Jos? Carlos Saraiva
dc.contributor.authorID.fl_str_mv CPF: 057.185.477-00
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1129995417777144
dc.contributor.author.fl_str_mv Magalh?es, Viviane de Souza
contributor_str_mv Scott, Fabio Barbour
Fernandes, Julio Israel
Gon?alves, Jos? Carlos Saraiva
dc.subject.por.fl_str_mv macrolactonas,
farmacocin?tica
cromatografia l?quida
topic macrolactonas,
farmacocin?tica
cromatografia l?quida
macrolactones, ,
pharmacokinetics
liquid chromatography
Medicina Veterin?ria
dc.subject.eng.fl_str_mv macrolactones, ,
pharmacokinetics
liquid chromatography
dc.subject.cnpq.fl_str_mv Medicina Veterin?ria
description getting closer and concern for the control of diseases increasing. This control is often performed with the use of chemicals known as insecticides. Among them, ivermectin is extremely widespread use because of its proven safety. Its use in dogs is suitable for the treatment of mite dermodicosi and heartworm prevention, but is extremely informally used for the control of fleas and ticks. Among the most common ectoparasites in dogs are the Rhipcephalus sanguineus tick and Ctenocephalides felis felis flea. In order to evaluate the efficacy of ivermectin against these parasites, along with treatment follow the profile of plasma tested formulation of ivermectin, a method was developed for quantification of ivermectin in canine plasma using liquid chromatography with fluorescence detection. This method was validated based on the recommendations of the National Agency of Sanitary Surveillance for validation of analytical methods and bioanalytical, Resolution RE n ? 899/2003. The samples collected during the test effectiveness using this method were analyzed and showed good bioavailability with Cmax 350 ng.mL-1 in four (4) hour and at AUC of 8411. Although the formulation have shown good absorption efficacy values found for Rhipcephalus sanguineus and Ctenocephalides felis felis were very low showing this is not the most appropriate treatment for the control of these parasites.
publishDate 2012
dc.date.issued.fl_str_mv 2012-02-24
dc.date.accessioned.fl_str_mv 2020-06-23T18:49:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv MAGALH~ES, Viviane de Souza. Avalia??o da curva de concentra??o plasm?tica e efic?cia da ivermectina oral em c?es contra Ctenocephalides felis felis e Rhipicephalus sanguineus. 2012. 56 f. Disserta??o (Mestrado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2012.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/3660
identifier_str_mv MAGALH~ES, Viviane de Souza. Avalia??o da curva de concentra??o plasm?tica e efic?cia da ivermectina oral em c?es contra Ctenocephalides felis felis e Rhipicephalus sanguineus. 2012. 56 f. Disserta??o (Mestrado em Ci?ncias Veterin?rias) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2012.
url https://tede.ufrrj.br/jspui/handle/jspui/3660
dc.language.iso.fl_str_mv por
language por
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repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da UFRRJ - Universidade Federal Rural do Rio de Janeiro (UFRRJ)
repository.mail.fl_str_mv bibliot@ufrrj.br||bibliot@ufrrj.br
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