Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos.

Detalhes bibliográficos
Ano de defesa: 2025
Autor(a) principal: Quina, Demetrio de Almeida lattes
Orientador(a): Oliveira, Renata Nunes lattes
Banca de defesa: Oliveira, Renata Nunes lattes, Bonci, Mário Mendes lattes, Bigansolli, Antonio Renato lattes, Middea, Antonieta lattes
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal Rural do Rio de Janeiro
Programa de Pós-Graduação: Programa de Pós-Graduação em Engenharia Química
Departamento: Instituto de Tecnologia
País: Brasil
Palavras-chave em Português:
Esporotricose felina
itraconazol
Alginato de Sódio
Palatabilidade
Feline sporotrichosis
Itraconazole
Sodium alginate
Palatability
Área do conhecimento CNPq:
Engenharia Química
Link de acesso: https://rima.ufrrj.br/jspui/handle/20.500.14407/24323
Resumo: A esporotricose felina é uma micose subcutânea de relevância zoonótica crescente no Brasil, especialmente no estado do Rio de Janeiro. O tratamento com itraconazol, embora eficaz, apresenta baixa adesão por parte dos gatos, devido à rejeição ao sabor amargo e à dificuldade de administração forçada. Esta dissertação propõe a encapsulação do fármaco itraconazol em esferas de alginato de sódio saborizadas com extrato de carne, visando maior palatabilidade, adesão voluntária e eficácia terapêutica. As esferas foram produzidas por gelificação iônica e caracterizadas por FTIR (Fourier transform infrared spectroscopy), Raman, MEV (Microscopia Eletrônica de Varredura), HPLC (High Performance Liquid Chromatography) e ensaios de inibição fúngica. Os resultados confirmaram o encapsulamento, a interação entre fármaco e matriz, e a atividade antifúngica das formulações, especialmente na presença de proteínas do extrato de carne, sugerindo possível sinergia com o fármaco. A proposta apresenta viabilidade tecnológica e potencial aplicação no controle da esporotricose, oferecendo uma alternativa eficaz, acessível e adaptada ao comportamento alimentar felino.
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spelling Quina, Demetrio de AlmeidaOliveira, Renata Nuneshttps://orcid.org/0000-0001-9782-269Xhttp://lattes.cnpq.br/9026953896544145Oliveira, Renata Nuneshttps://orcid.org/0000-0001-9782-269Xhttp://lattes.cnpq.br/9026953896544145Bonci, Mário Mendeshttps://orcid.org/0000-0002-3837-7378http://lattes.cnpq.br/6383796387620437Bigansolli, Antonio Renatohttps://orcid.org/0000-0002-0142-5989http://lattes.cnpq.br/5868109671445446Middea, Antonietahttp://lattes.cnpq.br/0641524479927336https://orcid.org/0009-0001-4963-5555http://lattes.cnpq.br/23811189309336982025-12-10T16:11:44Z2025-12-10T16:11:44Z2025-09-24QUINA, Demetrio de Almeida. Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos. 2025. 82 f. Dissertação (Mestrado em Engenharia Química) - Instituto de Tecnologia, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2025.https://rima.ufrrj.br/jspui/handle/20.500.14407/24323A esporotricose felina é uma micose subcutânea de relevância zoonótica crescente no Brasil, especialmente no estado do Rio de Janeiro. O tratamento com itraconazol, embora eficaz, apresenta baixa adesão por parte dos gatos, devido à rejeição ao sabor amargo e à dificuldade de administração forçada. Esta dissertação propõe a encapsulação do fármaco itraconazol em esferas de alginato de sódio saborizadas com extrato de carne, visando maior palatabilidade, adesão voluntária e eficácia terapêutica. As esferas foram produzidas por gelificação iônica e caracterizadas por FTIR (Fourier transform infrared spectroscopy), Raman, MEV (Microscopia Eletrônica de Varredura), HPLC (High Performance Liquid Chromatography) e ensaios de inibição fúngica. Os resultados confirmaram o encapsulamento, a interação entre fármaco e matriz, e a atividade antifúngica das formulações, especialmente na presença de proteínas do extrato de carne, sugerindo possível sinergia com o fármaco. A proposta apresenta viabilidade tecnológica e potencial aplicação no controle da esporotricose, oferecendo uma alternativa eficaz, acessível e adaptada ao comportamento alimentar felino.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESFeline sporotrichosis is a subcutaneous mycosis of increasing zoonotic relevance in Brazil, especially in the state of Rio de Janeiro. Although itraconazole is an effective treatment, it often shows low adherence by cats due to the drug's bitter taste and the difficulties of forced administration. This dissertation proposes the encapsulation of itraconazole in sodium alginate spheres flavored with meat extract, aiming to improve palatability, voluntary intake, and therapeutic efficacy. The spheres were produced by ionic gelation and characterized by FTIR, Raman spectroscopy, SEM, HPLC, and fungal growth inhibition assays. The results confirmed the encapsulation, interaction between the drug and the polymer matrix, and antifungal activity of the formulations, particularly in the presence of proteins from the meat extract, suggesting a possible synergistic effect. This approach demonstrates technological feasibility and potential application programs for controlling feline sporotrichosis, offering an effective, accessible, and behaviorally adapted alternative for veterinary treatment.porUniversidade Federal Rural do Rio de JaneiroPrograma de Pós-Graduação em Engenharia QuímicaUFRRJBrasilInstituto de TecnologiaEngenharia QuímicaEsporotricose felinaitraconazolAlginato de SódioPalatabilidadeFeline sporotrichosisItraconazoleSodium alginatePalatabilityEncapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos.Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisABOWSKA, M. B.; SKRODZKA, M.; SICIŃSKA, H.; MICHALAK, I.; DETYNA, J. Influence of cross-linking conditions on drying kinetics of alginate hydrogel. Gels, v. 9, n. 1, p. 63, 2023. 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dc.title.pt_BR.fl_str_mv Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos.
dc.title.alternative.en.fl_str_mv Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos.
title Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos.
spellingShingle Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos.
Quina, Demetrio de Almeida
Engenharia Química
Esporotricose felina
itraconazol
Alginato de Sódio
Palatabilidade
Feline sporotrichosis
Itraconazole
Sodium alginate
Palatability
title_short Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos.
title_full Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos.
title_fullStr Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos.
title_full_unstemmed Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos.
title_sort Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos.
author Quina, Demetrio de Almeida
author_facet Quina, Demetrio de Almeida
author_role author
dc.contributor.author.fl_str_mv Quina, Demetrio de Almeida
dc.contributor.advisor1.fl_str_mv Oliveira, Renata Nunes
dc.contributor.advisor1ID.fl_str_mv https://orcid.org/0000-0001-9782-269X
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/9026953896544145
dc.contributor.referee1.fl_str_mv Oliveira, Renata Nunes
dc.contributor.referee1ID.fl_str_mv https://orcid.org/0000-0001-9782-269X
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/9026953896544145
dc.contributor.referee2.fl_str_mv Bonci, Mário Mendes
dc.contributor.referee2ID.fl_str_mv https://orcid.org/0000-0002-3837-7378
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/6383796387620437
dc.contributor.referee3.fl_str_mv Bigansolli, Antonio Renato
dc.contributor.referee3ID.fl_str_mv https://orcid.org/0000-0002-0142-5989
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/5868109671445446
dc.contributor.referee4.fl_str_mv Middea, Antonieta
dc.contributor.referee4Lattes.fl_str_mv http://lattes.cnpq.br/0641524479927336
dc.contributor.authorID.fl_str_mv https://orcid.org/0009-0001-4963-5555
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/2381118930933698
contributor_str_mv Oliveira, Renata Nunes
Oliveira, Renata Nunes
Bonci, Mário Mendes
Bigansolli, Antonio Renato
Middea, Antonieta
dc.subject.cnpq.fl_str_mv Engenharia Química
topic Engenharia Química
Esporotricose felina
itraconazol
Alginato de Sódio
Palatabilidade
Feline sporotrichosis
Itraconazole
Sodium alginate
Palatability
dc.subject.por.fl_str_mv Esporotricose felina
itraconazol
Alginato de Sódio
Palatabilidade
Feline sporotrichosis
Itraconazole
Sodium alginate
Palatability
description A esporotricose felina é uma micose subcutânea de relevância zoonótica crescente no Brasil, especialmente no estado do Rio de Janeiro. O tratamento com itraconazol, embora eficaz, apresenta baixa adesão por parte dos gatos, devido à rejeição ao sabor amargo e à dificuldade de administração forçada. Esta dissertação propõe a encapsulação do fármaco itraconazol em esferas de alginato de sódio saborizadas com extrato de carne, visando maior palatabilidade, adesão voluntária e eficácia terapêutica. As esferas foram produzidas por gelificação iônica e caracterizadas por FTIR (Fourier transform infrared spectroscopy), Raman, MEV (Microscopia Eletrônica de Varredura), HPLC (High Performance Liquid Chromatography) e ensaios de inibição fúngica. Os resultados confirmaram o encapsulamento, a interação entre fármaco e matriz, e a atividade antifúngica das formulações, especialmente na presença de proteínas do extrato de carne, sugerindo possível sinergia com o fármaco. A proposta apresenta viabilidade tecnológica e potencial aplicação no controle da esporotricose, oferecendo uma alternativa eficaz, acessível e adaptada ao comportamento alimentar felino.
publishDate 2025
dc.date.accessioned.fl_str_mv 2025-12-10T16:11:44Z
dc.date.available.fl_str_mv 2025-12-10T16:11:44Z
dc.date.issued.fl_str_mv 2025-09-24
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv QUINA, Demetrio de Almeida. Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos. 2025. 82 f. Dissertação (Mestrado em Engenharia Química) - Instituto de Tecnologia, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2025.
dc.identifier.uri.fl_str_mv https://rima.ufrrj.br/jspui/handle/20.500.14407/24323
identifier_str_mv QUINA, Demetrio de Almeida. Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos. 2025. 82 f. Dissertação (Mestrado em Engenharia Química) - Instituto de Tecnologia, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2025.
url https://rima.ufrrj.br/jspui/handle/20.500.14407/24323
dc.language.iso.fl_str_mv por
language por
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