Antipsicóticos em efluente hospitalar: ocorrência, método cromatográfico, avaliação de risco e ozonização
Ano de defesa: | 2018 |
---|---|
Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
Centro de Ciências Naturais e Exatas |
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Química
|
Departamento: |
Química
|
País: |
Brasil
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/16527 |
Resumo: | Residues of psychoactive drugs in environmental samples have received great attention in recent years due to the high consumption and the impacts they can cause to ecosystems and also to human health. The objective of this study was to establish chromatographic methods of HPLC-DAD-FLD and LC-ESI-MS, to verify the occurrence of six antipsychotic drugs (risperidone, olanzapine, haloperidol, clozapine, chlorpromazine and pimozide) in hospital effluent, in order to evaluate the preliminary ecotoxicological risk and to propose advanced oxidation processes for the degradation of analytes in the hospital effluent matrix. Initially, the solid-phase extraction and liquidliquid dispersion microextraction procedures were optimized through experimental designs and, subsequently, the procedures were validated as recommended by national and international rules. Both extraction procedures showed good linearity, quantification limits <1.4 μg L-1, good accuracy (recoveries from 70.2% to 101.2%) with RSD<20%, analytical curves with normal and homocedastic distribution and independent residuos for all the analytes. Extraction procedures were applied to quantify the six antipsychotics studied during a week of collection, in which olanzapine, clozapine, haloperidol, risperidone and chlorpromazine were found in at least one collection point. Preliminary assessment of the ecotoxicological risk was carried out through the risk quotient, and the analytes clozapine, chlorpromazine and risperidone show high environmental risk. Photolysis and ozonation processes were used to study the degradation of the antipsychotics. In both processes, the degradation of the selected pychodrugs was evaluated in hospital effluent with different pH values (5, 7 and 9) for 60 min. When comparing the process efficiencies, it can be concluded that the antipsychotics show greater degradation by the ozonization, and the degradation of all compounds was conform to a pseudo-first-order kinetics, in both processes. For the photolysis, the antipsychotic showing the lowest rate of degradation was clozapine, and chlorpromazine was degraded with higher efficiency. For this process, the half-life of the analytes ranged from 6.3 to 43.3 min. Applying ozonation, the antipsychotics clozapine and olanzapine showed higher and lower degradation rates, and the half-life times ranged from 3.9 to 15.1 min, respectively. Thus, advanced oxidation processes prove to be alternates (preand / or post-treatment) pertinent to the removal of antipsychotic residues from the hospital effluent matrix, since such psychoactive drugs show properties of persistence, bioaccumulation and toxicity to non-target organisms. |
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Biblioteca Digital de Teses e Dissertações do UFSM |
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2019-05-10T17:19:18Z2019-05-10T17:19:18Z2018-09-06http://repositorio.ufsm.br/handle/1/16527Residues of psychoactive drugs in environmental samples have received great attention in recent years due to the high consumption and the impacts they can cause to ecosystems and also to human health. The objective of this study was to establish chromatographic methods of HPLC-DAD-FLD and LC-ESI-MS, to verify the occurrence of six antipsychotic drugs (risperidone, olanzapine, haloperidol, clozapine, chlorpromazine and pimozide) in hospital effluent, in order to evaluate the preliminary ecotoxicological risk and to propose advanced oxidation processes for the degradation of analytes in the hospital effluent matrix. Initially, the solid-phase extraction and liquidliquid dispersion microextraction procedures were optimized through experimental designs and, subsequently, the procedures were validated as recommended by national and international rules. Both extraction procedures showed good linearity, quantification limits <1.4 μg L-1, good accuracy (recoveries from 70.2% to 101.2%) with RSD<20%, analytical curves with normal and homocedastic distribution and independent residuos for all the analytes. Extraction procedures were applied to quantify the six antipsychotics studied during a week of collection, in which olanzapine, clozapine, haloperidol, risperidone and chlorpromazine were found in at least one collection point. Preliminary assessment of the ecotoxicological risk was carried out through the risk quotient, and the analytes clozapine, chlorpromazine and risperidone show high environmental risk. Photolysis and ozonation processes were used to study the degradation of the antipsychotics. In both processes, the degradation of the selected pychodrugs was evaluated in hospital effluent with different pH values (5, 7 and 9) for 60 min. When comparing the process efficiencies, it can be concluded that the antipsychotics show greater degradation by the ozonization, and the degradation of all compounds was conform to a pseudo-first-order kinetics, in both processes. For the photolysis, the antipsychotic showing the lowest rate of degradation was clozapine, and chlorpromazine was degraded with higher efficiency. For this process, the half-life of the analytes ranged from 6.3 to 43.3 min. Applying ozonation, the antipsychotics clozapine and olanzapine showed higher and lower degradation rates, and the half-life times ranged from 3.9 to 15.1 min, respectively. Thus, advanced oxidation processes prove to be alternates (preand / or post-treatment) pertinent to the removal of antipsychotic residues from the hospital effluent matrix, since such psychoactive drugs show properties of persistence, bioaccumulation and toxicity to non-target organisms.Resíduos de fármacos psicoativos em amostras ambientais têm recebido grande atenção nos últimos anos, devido ao elevado consumo, aos impactos que podem causar aos ecossistemas e, também, à saúde humana. Os objetivos deste estudo consistem em estabelecer métodos cromatográficos por meio de HPLC-DAD-FLD e LC-ESI-MS, verificar a ocorrência de seis fármacos antipsicóticos (risperidona, olanzapina, haloperidol, clozapina, clorpromazina e pimozida) em efluente hospitalar, avaliar o risco preliminar ecotoxicológico e propor processos avançados de oxidação para a degradação dos analitos na matriz de efluente hospitalar. Inicialmente, os procedimentos de extração em fase sólida e microextração líquido-líquido dispersiva foram otimizados através de planejamentos experimentais e, posteriormente, os procedimentos foram validados conforme recomendado por normativas nacionais e internacionais. Ambos os procedimentos de extração demonstraram boa linearidade, limites de quantificação <1,4 μg L-1, boa exatidão (recuperações de 70,2% a 101,2%) com RSD<20%, curvas analíticas com distribuição normal, homocedástica e resíduos independentes para todos analitos. Os procedimentos de extração foram aplicados para a quantificação dos seis antipsicóticos estudados durante uma semana de coleta, na qual olanzapina, clozapina, haloperidol, risperidona e clorpromazina foram encontrados em, pelo menos, um ponto de coleta. A avaliação preliminar do risco ecotoxicológico foi feita através do quociente de risco e, os analitos clozapina, clorpromazina e risperidona, apresentaram risco elevado. Para o estudo da degradação dos antipsicóticos foram utilizados os processos de fotólise e ozonização. Em ambos os processos, a degradação dos antipsicóticos selecionados foi avaliada em efluente hospitalar com diferentes valores de pH (5, 7 e 9), durante 60 min. Quando comparadas as eficiências dos processos pode-se concluir que os antipsicóticos apresentam maior degradação utilizando-se ozonização; e a degradação de todos os compostos ajustou-se à cinética de pseudo-primeira ordem em ambos os processos. Para o processo de fotólise, o antipsicótico que apresentou a menor taxa de degradação foi a clozapina, e, a clorpromazina, foi o antipsicótico degradado com maior eficiência, sendo que, para esse processo, o tempo de meia-vida dos analitos variou de 6,3 a 43,3 min. Quando aplicada a ozonização, os antipsicóticos clozapina e olanzapina demonstraram maior e menor taxa de degradação, respectivamente, e os tempos de meia-vida variaram de 3,9 a 15,1 min. Assim, os processos avançados de oxidação demonstram ser alternativas (prée/ ou pós-tratamento) pertinentes à remoção de resíduos de antipsicóticos da matriz efluente hospitalar, uma vez que, tais psicofármacos apresentam propriedades de persistência, bioacumulação e toxicidade à organismos não-alvo.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESporUniversidade Federal de Santa MariaCentro de Ciências Naturais e ExatasPrograma de Pós-Graduação em QuímicaUFSMBrasilQuímicaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAntipsicóticosEfluente hospitalarMicroextração líquido-líquido dispersivaExtração em fase sólidaCromatografia líquidaProcessos avançados de oxidaçãoAntipsychoticsHospital effluentLiquid-liquid-dispersive microextractionSolid phase extractionLiquid chromatographyAdvanced oxidation processesCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICAAntipsicóticos em efluente hospitalar: ocorrência, método cromatográfico, avaliação de risco e ozonizaçãoAntipsychotics in hospital effluent: occurrence, chromatographic method, risk assessment and ozonationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisMartins, Ayrton Figueiredohttp://lattes.cnpq.br/2113532494494821Sirtori, Carlahttp://lattes.cnpq.br/4464252707748774Cabrera, Liziara da Costahttp://lattes.cnpq.br/2380427486727653Bizzi, Cezar Augustohttp://lattes.cnpq.br/2975070149037006Almeida, Carlos Alberto Araujo dehttp://lattes.cnpq.br/8218956827334831http://lattes.cnpq.br/8278974968183127Reichert, Jaqueline Fabiane100600000000600ade6000d-a348-4d49-a531-6500a65a153a8f9ea86b-8008-4ed1-9a8f-2d0a92c9c597e97ba5e1-bd70-4946-b35e-162e90baaf7b6234c603-d01d-4b51-9cac-f6f914e00a964f68e2ef-8a41-454c-95f8-e24b79255a5da94d5f18-0558-49b3-a28c-1d7bb19e3566reponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALTES_PPGQUIMICA_2018_REICHERT_JAQUELINE.pdfTES_PPGQUIMICA_2018_REICHERT_JAQUELINE.pdfTese de Doutoradoapplication/pdf3090194http://repositorio.ufsm.br/bitstream/1/16527/1/TES_PPGQUIMICA_2018_REICHERT_JAQUELINE.pdf35237442e551555fa97ca72e0490b81cMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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dc.title.por.fl_str_mv |
Antipsicóticos em efluente hospitalar: ocorrência, método cromatográfico, avaliação de risco e ozonização |
dc.title.alternative.eng.fl_str_mv |
Antipsychotics in hospital effluent: occurrence, chromatographic method, risk assessment and ozonation |
title |
Antipsicóticos em efluente hospitalar: ocorrência, método cromatográfico, avaliação de risco e ozonização |
spellingShingle |
Antipsicóticos em efluente hospitalar: ocorrência, método cromatográfico, avaliação de risco e ozonização Reichert, Jaqueline Fabiane Antipsicóticos Efluente hospitalar Microextração líquido-líquido dispersiva Extração em fase sólida Cromatografia líquida Processos avançados de oxidação Antipsychotics Hospital effluent Liquid-liquid-dispersive microextraction Solid phase extraction Liquid chromatography Advanced oxidation processes CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Antipsicóticos em efluente hospitalar: ocorrência, método cromatográfico, avaliação de risco e ozonização |
title_full |
Antipsicóticos em efluente hospitalar: ocorrência, método cromatográfico, avaliação de risco e ozonização |
title_fullStr |
Antipsicóticos em efluente hospitalar: ocorrência, método cromatográfico, avaliação de risco e ozonização |
title_full_unstemmed |
Antipsicóticos em efluente hospitalar: ocorrência, método cromatográfico, avaliação de risco e ozonização |
title_sort |
Antipsicóticos em efluente hospitalar: ocorrência, método cromatográfico, avaliação de risco e ozonização |
author |
Reichert, Jaqueline Fabiane |
author_facet |
Reichert, Jaqueline Fabiane |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Martins, Ayrton Figueiredo |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/2113532494494821 |
dc.contributor.referee1.fl_str_mv |
Sirtori, Carla |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/4464252707748774 |
dc.contributor.referee2.fl_str_mv |
Cabrera, Liziara da Costa |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/2380427486727653 |
dc.contributor.referee3.fl_str_mv |
Bizzi, Cezar Augusto |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/2975070149037006 |
dc.contributor.referee4.fl_str_mv |
Almeida, Carlos Alberto Araujo de |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/8218956827334831 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/8278974968183127 |
dc.contributor.author.fl_str_mv |
Reichert, Jaqueline Fabiane |
contributor_str_mv |
Martins, Ayrton Figueiredo Sirtori, Carla Cabrera, Liziara da Costa Bizzi, Cezar Augusto Almeida, Carlos Alberto Araujo de |
dc.subject.por.fl_str_mv |
Antipsicóticos Efluente hospitalar Microextração líquido-líquido dispersiva Extração em fase sólida Cromatografia líquida Processos avançados de oxidação |
topic |
Antipsicóticos Efluente hospitalar Microextração líquido-líquido dispersiva Extração em fase sólida Cromatografia líquida Processos avançados de oxidação Antipsychotics Hospital effluent Liquid-liquid-dispersive microextraction Solid phase extraction Liquid chromatography Advanced oxidation processes CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
Antipsychotics Hospital effluent Liquid-liquid-dispersive microextraction Solid phase extraction Liquid chromatography Advanced oxidation processes |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
Residues of psychoactive drugs in environmental samples have received great attention in recent years due to the high consumption and the impacts they can cause to ecosystems and also to human health. The objective of this study was to establish chromatographic methods of HPLC-DAD-FLD and LC-ESI-MS, to verify the occurrence of six antipsychotic drugs (risperidone, olanzapine, haloperidol, clozapine, chlorpromazine and pimozide) in hospital effluent, in order to evaluate the preliminary ecotoxicological risk and to propose advanced oxidation processes for the degradation of analytes in the hospital effluent matrix. Initially, the solid-phase extraction and liquidliquid dispersion microextraction procedures were optimized through experimental designs and, subsequently, the procedures were validated as recommended by national and international rules. Both extraction procedures showed good linearity, quantification limits <1.4 μg L-1, good accuracy (recoveries from 70.2% to 101.2%) with RSD<20%, analytical curves with normal and homocedastic distribution and independent residuos for all the analytes. Extraction procedures were applied to quantify the six antipsychotics studied during a week of collection, in which olanzapine, clozapine, haloperidol, risperidone and chlorpromazine were found in at least one collection point. Preliminary assessment of the ecotoxicological risk was carried out through the risk quotient, and the analytes clozapine, chlorpromazine and risperidone show high environmental risk. Photolysis and ozonation processes were used to study the degradation of the antipsychotics. In both processes, the degradation of the selected pychodrugs was evaluated in hospital effluent with different pH values (5, 7 and 9) for 60 min. When comparing the process efficiencies, it can be concluded that the antipsychotics show greater degradation by the ozonization, and the degradation of all compounds was conform to a pseudo-first-order kinetics, in both processes. For the photolysis, the antipsychotic showing the lowest rate of degradation was clozapine, and chlorpromazine was degraded with higher efficiency. For this process, the half-life of the analytes ranged from 6.3 to 43.3 min. Applying ozonation, the antipsychotics clozapine and olanzapine showed higher and lower degradation rates, and the half-life times ranged from 3.9 to 15.1 min, respectively. Thus, advanced oxidation processes prove to be alternates (preand / or post-treatment) pertinent to the removal of antipsychotic residues from the hospital effluent matrix, since such psychoactive drugs show properties of persistence, bioaccumulation and toxicity to non-target organisms. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-09-06 |
dc.date.accessioned.fl_str_mv |
2019-05-10T17:19:18Z |
dc.date.available.fl_str_mv |
2019-05-10T17:19:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/16527 |
url |
http://repositorio.ufsm.br/handle/1/16527 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
100600000000 |
dc.relation.confidence.fl_str_mv |
600 |
dc.relation.authority.fl_str_mv |
ade6000d-a348-4d49-a531-6500a65a153a 8f9ea86b-8008-4ed1-9a8f-2d0a92c9c597 e97ba5e1-bd70-4946-b35e-162e90baaf7b 6234c603-d01d-4b51-9cac-f6f914e00a96 4f68e2ef-8a41-454c-95f8-e24b79255a5d a94d5f18-0558-49b3-a28c-1d7bb19e3566 |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Naturais e Exatas |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Química |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Química |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Naturais e Exatas |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações do UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Biblioteca Digital de Teses e Dissertações do UFSM |
collection |
Biblioteca Digital de Teses e Dissertações do UFSM |
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MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
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1793240081140547584 |