Obtenção de novos heterociclos derivados do ácido levulínico
Ano de defesa: | 2013 |
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Autor(a) principal: | |
Orientador(a): | |
Banca de defesa: | , , , |
Tipo de documento: | Tese |
Tipo de acesso: | Acesso aberto |
Idioma: | por |
Instituição de defesa: |
Universidade Federal de Santa Maria
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Química
|
Departamento: |
Química
|
País: |
BR
|
Palavras-chave em Português: | |
Palavras-chave em Inglês: | |
Área do conhecimento CNPq: | |
Link de acesso: | http://repositorio.ufsm.br/handle/1/4263 |
Resumo: | This study describes the attainment of twenty three (23) bis-heterocycles derived from the Levulinic Acid: Bis-Pyrazoles (6a-k) by the reaction of cyclecondensation between the 3-(5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-il)propanohidrazidamand a series of replaced β-alcoxiviniltrifluorometilcetonas. 1,3,4-oxadiazole 2-5-disubstituted (8-11) by reactions like [4 + 1] [OCNN+C], through the reactions of cyclecondensation between the 3-(5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl)propanohidrazida with different orthoesters as well as with carbon disulfide. It was also produced hydrazides (16c-d, g-h e 17c-d, g-h) derived of synthesized pyrimidines, to be used as precursorsn in the synthesis of bis-heterocycles, derivatizated of the reaction of those with some β- Ketones alcoxiviniltrifluormetil. The bis-heterocycles were obtained by the ordinary methodology, with efficiency between 61-97%.It was also gotten other original compounds (3i-k, 5), used as precursors in this study. The structure of these synthesized compounds were confirmed by the data of RMN 1H, 13C, besides the data of mass spectrometry. |
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2017-05-182017-05-182013-09-30FRIGO, Leandro Marcon. Attainment of new heterocycles derived from levulinic acid. 2013. 230 f. Tese (Doutorado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2013.http://repositorio.ufsm.br/handle/1/4263This study describes the attainment of twenty three (23) bis-heterocycles derived from the Levulinic Acid: Bis-Pyrazoles (6a-k) by the reaction of cyclecondensation between the 3-(5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-il)propanohidrazidamand a series of replaced β-alcoxiviniltrifluorometilcetonas. 1,3,4-oxadiazole 2-5-disubstituted (8-11) by reactions like [4 + 1] [OCNN+C], through the reactions of cyclecondensation between the 3-(5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl)propanohidrazida with different orthoesters as well as with carbon disulfide. It was also produced hydrazides (16c-d, g-h e 17c-d, g-h) derived of synthesized pyrimidines, to be used as precursorsn in the synthesis of bis-heterocycles, derivatizated of the reaction of those with some β- Ketones alcoxiviniltrifluormetil. The bis-heterocycles were obtained by the ordinary methodology, with efficiency between 61-97%.It was also gotten other original compounds (3i-k, 5), used as precursors in this study. The structure of these synthesized compounds were confirmed by the data of RMN 1H, 13C, besides the data of mass spectrometry.Este trabalho descreve a obtenção de 23 novos bis-heterociclos derivados do Ácido Levulínico: Bis-Pirazóis (6a-k) a partir da reação de ciclocondensação entre o 3-(5-(trifluorometil)-4,5-dihidro-1H-pirazol-3-il)propanohidrazida e uma série de β-alcoxiviniltrifluorometilcetonas substituídas; 1,3,4-oxadiazóis 2-5-dissubstituídos (8-11) via reações do tipo [4 + 1] [OCNN+C], através de reações de ciclocondensação entre a 3-(5-(trifluorometil)-4,5-dihidro-1H-pirazol-3-il)propanohidrazida com diferentes ortoésteres, bem como com dissulfeto de carbono. Foram produzidas ainda, hidrazidas( 16c-d, g-h e 17c-d, g-h) derivadas de pirimidinas sintetizadas, para serem utilizadas como precursores na síntese de bis-heterociclos, derivatizados da reação destas com algumas β-alcoxiviniltrifluormetil cetonas. Os bis-heterociclos foram obtidos por metodologia convencional, com rendimentos entre 61-97%. Foram obtidos ainda outros compostos inéditos (3i-k, 5) utilizados como precursores nesse trabalho. As estruturas dos compostos sintetizados foram confirmadas por dados de RMN 1H, 13C, além de dados de espectrometria de massas.Conselho Nacional de Desenvolvimento Científico e Tecnológicoapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em QuímicaUFSMBRQuímicaOxadiazóisPirimidinasPirazóisBis-heterociclosOxadiazolePyrimidinesPyrazolesBis-heterocyclesCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICAObtenção de novos heterociclos derivados do ácido levulínicoAttainment of new heterocycles derived from levulinic acidinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisFlores, Alex Fabiani Clarohttp://lattes.cnpq.br/1159954352174167Morel, Ademir Fariashttp://lattes.cnpq.br/3554994385525333Siqueira, Geonir Machadohttp://lattes.cnpq.br/3245577879591660Mostardeiro, Marco Aureliohttp://lattes.cnpq.br/6195396264565980Beck, Paulo Henriquehttp://lattes.cnpq.br/4175014494565472http://lattes.cnpq.br/3667993659461271Frigo, Leandro Marcon1006000000004003005005003003003008a4555ae-c246-4b1a-adac-bf3b2784da08b9c70ee1-03cf-46d9-a2c3-087aa581f24f22df5f67-c304-4742-b982-4d1e6d30aecc39dc23ab-ef8b-429d-9c37-d1efcde74a4c1ec253ee-25dd-4b17-801e-c4bf7312a9d8ca1df483-94db-4ec1-824c-b40d1aad0037info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALFRIGO, LEANDRO MARCON.pdfapplication/pdf18769634http://repositorio.ufsm.br/bitstream/1/4263/1/FRIGO%2c%20LEANDRO%20MARCON.pdfec574254180abe9ef35e075e52f076b3MD51TEXTFRIGO, LEANDRO MARCON.pdf.txtFRIGO, LEANDRO MARCON.pdf.txtExtracted texttext/plain209559http://repositorio.ufsm.br/bitstream/1/4263/2/FRIGO%2c%20LEANDRO%20MARCON.pdf.txte4d24ce117991afaad3c07b79ed2d553MD52THUMBNAILFRIGO, LEANDRO MARCON.pdf.jpgFRIGO, LEANDRO MARCON.pdf.jpgIM Thumbnailimage/jpeg5805http://repositorio.ufsm.br/bitstream/1/4263/3/FRIGO%2c%20LEANDRO%20MARCON.pdf.jpgab23b0ac8baae2b2d57f8ee4ada33bf7MD531/42632022-08-29 14:16:26.093oai:repositorio.ufsm.br:1/4263Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2022-08-29T17:16:26Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Obtenção de novos heterociclos derivados do ácido levulínico |
dc.title.alternative.eng.fl_str_mv |
Attainment of new heterocycles derived from levulinic acid |
title |
Obtenção de novos heterociclos derivados do ácido levulínico |
spellingShingle |
Obtenção de novos heterociclos derivados do ácido levulínico Frigo, Leandro Marcon Oxadiazóis Pirimidinas Pirazóis Bis-heterociclos Oxadiazole Pyrimidines Pyrazoles Bis-heterocycles CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Obtenção de novos heterociclos derivados do ácido levulínico |
title_full |
Obtenção de novos heterociclos derivados do ácido levulínico |
title_fullStr |
Obtenção de novos heterociclos derivados do ácido levulínico |
title_full_unstemmed |
Obtenção de novos heterociclos derivados do ácido levulínico |
title_sort |
Obtenção de novos heterociclos derivados do ácido levulínico |
author |
Frigo, Leandro Marcon |
author_facet |
Frigo, Leandro Marcon |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Flores, Alex Fabiani Claro |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1159954352174167 |
dc.contributor.referee1.fl_str_mv |
Morel, Ademir Farias |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/3554994385525333 |
dc.contributor.referee2.fl_str_mv |
Siqueira, Geonir Machado |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/3245577879591660 |
dc.contributor.referee3.fl_str_mv |
Mostardeiro, Marco Aurelio |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/6195396264565980 |
dc.contributor.referee4.fl_str_mv |
Beck, Paulo Henrique |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/4175014494565472 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3667993659461271 |
dc.contributor.author.fl_str_mv |
Frigo, Leandro Marcon |
contributor_str_mv |
Flores, Alex Fabiani Claro Morel, Ademir Farias Siqueira, Geonir Machado Mostardeiro, Marco Aurelio Beck, Paulo Henrique |
dc.subject.por.fl_str_mv |
Oxadiazóis Pirimidinas Pirazóis Bis-heterociclos |
topic |
Oxadiazóis Pirimidinas Pirazóis Bis-heterociclos Oxadiazole Pyrimidines Pyrazoles Bis-heterocycles CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
Oxadiazole Pyrimidines Pyrazoles Bis-heterocycles |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
This study describes the attainment of twenty three (23) bis-heterocycles derived from the Levulinic Acid: Bis-Pyrazoles (6a-k) by the reaction of cyclecondensation between the 3-(5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-il)propanohidrazidamand a series of replaced β-alcoxiviniltrifluorometilcetonas. 1,3,4-oxadiazole 2-5-disubstituted (8-11) by reactions like [4 + 1] [OCNN+C], through the reactions of cyclecondensation between the 3-(5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl)propanohidrazida with different orthoesters as well as with carbon disulfide. It was also produced hydrazides (16c-d, g-h e 17c-d, g-h) derived of synthesized pyrimidines, to be used as precursorsn in the synthesis of bis-heterocycles, derivatizated of the reaction of those with some β- Ketones alcoxiviniltrifluormetil. The bis-heterocycles were obtained by the ordinary methodology, with efficiency between 61-97%.It was also gotten other original compounds (3i-k, 5), used as precursors in this study. The structure of these synthesized compounds were confirmed by the data of RMN 1H, 13C, besides the data of mass spectrometry. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-09-30 |
dc.date.accessioned.fl_str_mv |
2017-05-18 |
dc.date.available.fl_str_mv |
2017-05-18 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FRIGO, Leandro Marcon. Attainment of new heterocycles derived from levulinic acid. 2013. 230 f. Tese (Doutorado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/4263 |
identifier_str_mv |
FRIGO, Leandro Marcon. Attainment of new heterocycles derived from levulinic acid. 2013. 230 f. Tese (Doutorado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2013. |
url |
http://repositorio.ufsm.br/handle/1/4263 |
dc.language.iso.fl_str_mv |
por |
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por |
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100600000000 |
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openAccess |
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Universidade Federal de Santa Maria |
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Programa de Pós-Graduação em Química |
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UFSM |
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BR |
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Química |
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Universidade Federal de Santa Maria |
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