Comparação entre as técnicas de panfotocoagulação utilizando laser 577 nm de multidisparos versus panfotocoagulação convencional no tratamento da retinopatia diabética

• Ano de defesa: 2021
• Autor(a) principal: Passos, Renato Magalhaes [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• dARK ID: ark:/48912/0013000021fjk
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Diabetic Retinopathy; Laser Photocoagulation; Laser Therapy; Blindness/Prevention & Control; Retinopatia Diabética; Fotocoagulação A Laser; Terapia A Laser; Cegueira/Prevenção & Controle
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=11182764; https://repositorio.unifesp.br/handle/11600/68328

Purpose: To compare the outcomes after panretinal photocoagulation (PRP) with two different strategies for treating diabetic retinopathy (DR), based in criteria such as laser parameters, therapeutic response, and patient tolerance. Methods: This single-center, randomized clinical study included 41 eyes with proliferative or severe non-proliferative DR. They were treated in group 1 with 577 nanometer (nm) multispot laser and 20 milliseconds (ms) pulse duration, while in group 2 they were treated with so-called conventional PRP with 532 nm single-spot laser and 100 ms pulse duration. The outcomes included functional evaluation with best-corrected visual acuity (BCVA) and structural evaluation with imaging methods (OCT and fluorescein angiogram) at baseline, 6 and 12 months. Other variables included laser parameters, number of PRP applications required, and results of a subjective pain analysis. Results: The multispot laser (group 1) required fewer PRP applications and more laser spots delivered (P<0.001) to compensate for lower fluence/pulse duration and provided a similar pain sensibility compared with single-spot laser. Both groups maintained the initial VAs and CRTs; about 50% of cases had vitreomacular interface changes and improved macular edema, with similar angiographic improvements after 12 months. New vessels regression was seen less frequently in both groups, possibly because of baseline disease severity rather than the treatment modality. Conclusions: Multispot laser demonstrated to be equivalent and non-inferior to conventional treatment with single spot laser for diabetic retinopathy, offering some advantages such as smaller number of sessions to finish PRP and a lower fluence to obtain the desired results, producing less retinal iatrogenic damage.