Avaliação do estado nutricional relativo a retinol, beta caroteno e zinco em pacientes com imunodeficiência comum variável

• Ano de defesa: 2010
• Autor(a) principal: Santos-Valente, Elisangela Calheiro dos [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• dARK ID: ark:/48912/001300001t3b5
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Beta carotene; Nutritional status; Risk groups nutrition; Vitamin A; Zinc; Common variable immunodeficiency; Beta caroteno; Estado nutricional; Nutrição de grupos de risco; Vitamina A; Zinco; Imunodeficiência de variável comum
• Link de acesso: https://repositorio.unifesp.br/handle/11600/9086

Introduction: Common Variable Immunodeficiency (CVI) patients presenting diarrhea and weight loss probably have impaired nutrient ingestion and absorption. Objectives: To compare vitamin A and zinc levels in CVI patients and healthy controls and also compare those levels with gastrointestinal (GI) symptoms and bacterial translocation. Methods: CVI patients from the Immunology outpatients clinic from the Federal University of Sao Paulo and age and gender-matched healthy controls underwent nutritional and laboratorial evaluation with CBC, C reactive protein (CRP), lipopolysaccharide (LPS), soluble CD14 (sCD14), retinol, beta carotene, serum and erythrocyte zinc. Results: Seventeen patients (mean age 28.54y) and 17 controls were included in the study. Retinol levels were lower in patients compared to controls: 1.99 ( }0.67) and 2.72ƒÊmol/L ( }0.96), respectively, p=0.014. Likewise, serum zinc levels were 50.0 (50-100) in the patients and 100.0ƒÊg/dL (50-150) in the control group, (p=0.020). For erythrocyte zinc the levels were 37.32 ( }10.51) for patients and 44.91ƒÊgZn/gHb ( }7.67) for controls, p=0.045. CRP levels were higher among patients: 4.99 (0.15-34.51), compared to controls: 0.55mg/L (0.17-6.06), p=0.004. There was no difference in the translocation marker levels between the groups. A tendency of lower retinol was seem in those patients with severe GI symptoms compared with those with mild/absent symptoms and health controls. Conclusions: CVI patients presented significant lower retinol and zinc levels and higher CRP levels than the healthy controls with no evidence of bacterial translocation. Nonetheless, those patients with severe GI symptoms tend to have lower retinol levels than the other patients.