Análise fractal de feridas dérmicas de coelhos tratadas com plasma rico em plaquetas e rosuvastatina

Detalhes bibliográficos
Ano de defesa: 2018
Autor(a) principal: Taniguchi, Bianca Ayumi Lima lattes
Orientador(a): Laposy, Cecília Braga lattes
Banca de defesa: Teixeira, Giovana Rampazzo lattes, Nai, Gisele Alborghetti lattes
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade do Oeste Paulista
Programa de Pós-Graduação: Mestrado em Ciência Animal
Departamento: Mestrado em Ciência Animal
País: Brasil
Palavras-chave em Português:
coelhos, dimensão fractal, PRP, rosuvastatina tópica, feridas
Palavras-chave em Inglês:
rabbits, fractal dimension, PRP, topical rosuvastatin, wounds
Área do conhecimento CNPq:
CIENCIAS AGRARIAS::MEDICINA VETERINARIA
Link de acesso: http://bdtd.unoeste.br:8080/jspui/handle/jspui/1114
Resumo: The cicatricial process comprises a sequence of events and cellular interacting to restore damaged tissue. Biomaterials such as platelet rich plasma (PRP) were widely used for a healing promotion, due to the better distribution of collagen. In addition, studies show that biomaterial-associated statistics can improve endothelial function and increase re-epithelialization. Analysis of collagen architecture is critical when it comes to healing. A form of evaluation used to individualize the changes in the history and quantify as the existing changes, more precisely, because it is a technique that is independent of the evaluator. This is a research program to evaluate the use of rosuvastatin (RSV) associated with autologous PRP in serial form, to analyze how the ability of expression through the fractal dimension. 100 skin biopsies induced experimentally by male adults, treated or not with PRP, RSV and association, were followed at 7,14 and 17 days. In all procedures there was a decrease in the DF, verified up to 170 days. The WF of the Wounds That Know the Departure of the Different Doses Seven Days (P <0.05), It was verified that, unlike PRP in a serious way, the reorganization of the fibers in the initial healing process can be favored. The use of DF for collagen evaluation proved to be reliable.
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spelling Laposy, Cecília Bragahttp://lattes.cnpq.br/6243360005165063Teixeira, Giovana Rampazzohttp://lattes.cnpq.br/2315704053720238Nai, Gisele Alborghettihttp://lattes.cnpq.br/60576062158501640969162855http://lattes.cnpq.br/0303722693043709Taniguchi, Bianca Ayumi Lima2018-11-22T13:38:33Z2018-09-27Taniguchi, Bianca Ayumi Lima. Análise fractal de feridas dérmicas de coelhos tratadas com plasma rico em plaquetas e rosuvastatina. 2018. 33f. Dissertação (Mestrado em Ciência Animal) - Universidade do Oeste Paulista, Presidente Prudente, 2018.http://bdtd.unoeste.br:8080/jspui/handle/jspui/1114The cicatricial process comprises a sequence of events and cellular interacting to restore damaged tissue. Biomaterials such as platelet rich plasma (PRP) were widely used for a healing promotion, due to the better distribution of collagen. In addition, studies show that biomaterial-associated statistics can improve endothelial function and increase re-epithelialization. Analysis of collagen architecture is critical when it comes to healing. A form of evaluation used to individualize the changes in the history and quantify as the existing changes, more precisely, because it is a technique that is independent of the evaluator. This is a research program to evaluate the use of rosuvastatin (RSV) associated with autologous PRP in serial form, to analyze how the ability of expression through the fractal dimension. 100 skin biopsies induced experimentally by male adults, treated or not with PRP, RSV and association, were followed at 7,14 and 17 days. In all procedures there was a decrease in the DF, verified up to 170 days. The WF of the Wounds That Know the Departure of the Different Doses Seven Days (P <0.05), It was verified that, unlike PRP in a serious way, the reorganization of the fibers in the initial healing process can be favored. The use of DF for collagen evaluation proved to be reliable.O processo cicatricial compreende uma sequência de eventos moleculares e celulares que interagem para restaurar o tecido lesado. Os biomateriais como o plasma rico em plaquetas (PRP) têm sido muito utilizados para a promoção de cicatrização, pela melhor distribuição do colágeno. Além disso, estudos mostram que as estatinas associadas a biomateriais podem melhorar a função endotelial e aumentar a reepitelização. A análise da arquitetura do colágeno é fundamental quando se trata de cicatrização. Uma forma de avaliação utilizada para identificar alterações estruturais na pele é a dimensão fractal, que permite caracterizar estruturas irregulares em lâminas histológicas e quantificar as alterações existentes, de maneira mais precisa, pois se trata de uma técnica que independe do avaliador. Este estudo teve por objetivo verificar a viabilidade do uso da rosuvastatina (RSV) associada ou não ao PRP autólogo de forma seriada, para analisar as fibras colágenas por meio da dimensão fractal. Foram utilizadas 100 biopsias de feridas de pele induzidas experimentalmente de coelhos adultos, machos, tratadas ou não com PRP, RSV e associação, que foram acompanhadas aos 7,14 e 17 dias. Em todos os tratamentos houve uma diminuição da DF, verificada até o 170 dia. A DF das feridas que receberam diferentes tratamentos foi menor nos primeiros sete dias (P<0,05), mostrando que a adição da RSV ao PRP de forma seriada pode favorecer a reorganização das fibras no processo de cicatrização inicial. A utilização da DF para avaliação de colágeno mostrou-se confiável.Submitted by Michele Mologni (mologni@unoeste.br) on 2018-11-22T13:38:33Z No. of bitstreams: 1 Bianca Ayumi Lima Taniguchi .pdf: 5557065 bytes, checksum: e2b995ff334324fa8c28140520d66d2b (MD5)Made available in DSpace on 2018-11-22T13:38:33Z (GMT). No. of bitstreams: 1 Bianca Ayumi Lima Taniguchi .pdf: 5557065 bytes, checksum: e2b995ff334324fa8c28140520d66d2b (MD5) Previous issue date: 2018-09-27application/pdfhttp://bdtd.unoeste.br:8080/jspui/retrieve/2867/Bianca%20Ayumi%20Lima%20Taniguchi%20.pdf.jpgporUniversidade do Oeste PaulistaMestrado em Ciência AnimalUNOESTEBrasilMestrado em Ciência Animalcoelhos, dimensão fractal, PRP, rosuvastatina tópica, feridasrabbits, fractal dimension, PRP, topical rosuvastatin, woundsCIENCIAS AGRARIAS::MEDICINA VETERINARIAAnálise fractal de feridas dérmicas de coelhos tratadas com plasma rico em plaquetas e rosuvastatinaFractal analysis of dermal wounds from rabbits treated with platelet rich plasma and rosuvastatininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis18867256397436141355005006001886725639743614135453670264235017319info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UNOESTEinstname:Universidade do Oeste Paulista (UNOESTE)instacron:UNOESTETHUMBNAILBianca Ayumi Lima Taniguchi .pdf.jpgBianca Ayumi Lima Taniguchi .pdf.jpgimage/jpeg2163http://bdtd.unoeste.br:8080/tede/bitstream/jspui/1114/3/Bianca+Ayumi+Lima+Taniguchi+.pdf.jpga9fa3011115c3dadbde84696a3684b78MD53ORIGINALBianca Ayumi Lima Taniguchi .pdfBianca Ayumi Lima Taniguchi .pdfapplication/pdf5557065http://bdtd.unoeste.br:8080/tede/bitstream/jspui/1114/2/Bianca+Ayumi+Lima+Taniguchi+.pdfe2b995ff334324fa8c28140520d66d2bMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82067http://bdtd.unoeste.br:8080/tede/bitstream/jspui/1114/1/license.txt47745281809acb27fb322a97f2d9cb88MD51jspui/11142018-11-23 00:59:58.41oai:bdtd.unoeste.br: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 Digital de Teses e Dissertaçõeshttp://bdtd.unoeste.br:8080/jspui/PUBhttp://bdtd.unoeste.br:8080/oai/requestbdtd@unoeste.bropendoar:2018-11-23T02:59:58Biblioteca Digital de Teses e Dissertações da UNOESTE - Universidade do Oeste Paulista (UNOESTE)false
dc.title.por.fl_str_mv Análise fractal de feridas dérmicas de coelhos tratadas com plasma rico em plaquetas e rosuvastatina
dc.title.alternative.eng.fl_str_mv Fractal analysis of dermal wounds from rabbits treated with platelet rich plasma and rosuvastatin
title Análise fractal de feridas dérmicas de coelhos tratadas com plasma rico em plaquetas e rosuvastatina
spellingShingle Análise fractal de feridas dérmicas de coelhos tratadas com plasma rico em plaquetas e rosuvastatina
Taniguchi, Bianca Ayumi Lima
coelhos, dimensão fractal, PRP, rosuvastatina tópica, feridas
rabbits, fractal dimension, PRP, topical rosuvastatin, wounds
CIENCIAS AGRARIAS::MEDICINA VETERINARIA
title_short Análise fractal de feridas dérmicas de coelhos tratadas com plasma rico em plaquetas e rosuvastatina
title_full Análise fractal de feridas dérmicas de coelhos tratadas com plasma rico em plaquetas e rosuvastatina
title_fullStr Análise fractal de feridas dérmicas de coelhos tratadas com plasma rico em plaquetas e rosuvastatina
title_full_unstemmed Análise fractal de feridas dérmicas de coelhos tratadas com plasma rico em plaquetas e rosuvastatina
title_sort Análise fractal de feridas dérmicas de coelhos tratadas com plasma rico em plaquetas e rosuvastatina
author Taniguchi, Bianca Ayumi Lima
author_facet Taniguchi, Bianca Ayumi Lima
author_role author
dc.contributor.advisor1.fl_str_mv Laposy, Cecília Braga
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/6243360005165063
dc.contributor.referee1.fl_str_mv Teixeira, Giovana Rampazzo
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/2315704053720238
dc.contributor.referee2.fl_str_mv Nai, Gisele Alborghetti
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/605760621585016
dc.contributor.authorID.fl_str_mv 40969162855
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/0303722693043709
dc.contributor.author.fl_str_mv Taniguchi, Bianca Ayumi Lima
contributor_str_mv Laposy, Cecília Braga
Teixeira, Giovana Rampazzo
Nai, Gisele Alborghetti
dc.subject.por.fl_str_mv coelhos, dimensão fractal, PRP, rosuvastatina tópica, feridas
topic coelhos, dimensão fractal, PRP, rosuvastatina tópica, feridas
rabbits, fractal dimension, PRP, topical rosuvastatin, wounds
CIENCIAS AGRARIAS::MEDICINA VETERINARIA
dc.subject.eng.fl_str_mv rabbits, fractal dimension, PRP, topical rosuvastatin, wounds
dc.subject.cnpq.fl_str_mv CIENCIAS AGRARIAS::MEDICINA VETERINARIA
description The cicatricial process comprises a sequence of events and cellular interacting to restore damaged tissue. Biomaterials such as platelet rich plasma (PRP) were widely used for a healing promotion, due to the better distribution of collagen. In addition, studies show that biomaterial-associated statistics can improve endothelial function and increase re-epithelialization. Analysis of collagen architecture is critical when it comes to healing. A form of evaluation used to individualize the changes in the history and quantify as the existing changes, more precisely, because it is a technique that is independent of the evaluator. This is a research program to evaluate the use of rosuvastatin (RSV) associated with autologous PRP in serial form, to analyze how the ability of expression through the fractal dimension. 100 skin biopsies induced experimentally by male adults, treated or not with PRP, RSV and association, were followed at 7,14 and 17 days. In all procedures there was a decrease in the DF, verified up to 170 days. The WF of the Wounds That Know the Departure of the Different Doses Seven Days (P <0.05), It was verified that, unlike PRP in a serious way, the reorganization of the fibers in the initial healing process can be favored. The use of DF for collagen evaluation proved to be reliable.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-11-22T13:38:33Z
dc.date.issued.fl_str_mv 2018-09-27
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dc.identifier.citation.fl_str_mv Taniguchi, Bianca Ayumi Lima. Análise fractal de feridas dérmicas de coelhos tratadas com plasma rico em plaquetas e rosuvastatina. 2018. 33f. Dissertação (Mestrado em Ciência Animal) - Universidade do Oeste Paulista, Presidente Prudente, 2018.
dc.identifier.uri.fl_str_mv http://bdtd.unoeste.br:8080/jspui/handle/jspui/1114
identifier_str_mv Taniguchi, Bianca Ayumi Lima. Análise fractal de feridas dérmicas de coelhos tratadas com plasma rico em plaquetas e rosuvastatina. 2018. 33f. Dissertação (Mestrado em Ciência Animal) - Universidade do Oeste Paulista, Presidente Prudente, 2018.
url http://bdtd.unoeste.br:8080/jspui/handle/jspui/1114
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dc.publisher.program.fl_str_mv Mestrado em Ciência Animal
dc.publisher.initials.fl_str_mv UNOESTE
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Mestrado em Ciência Animal
publisher.none.fl_str_mv Universidade do Oeste Paulista
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