Calcium hydroxyapatite combined with photobiomodulation for bone tissue repair

• Ano de defesa: 2025
• Autor(a) principal: Santos, Camila Pascoal Correia dos
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: eng
• Instituição de defesa: Biblioteca Digitais de Teses e Dissertações da USP
• Palavras-chave em Português: Bone regeneration; Durapatita; Durapatite; Engenharia tecidual; Low-level laser therapy; Medicina regenerativa; Regeneração óssea; Regenerative medicine; Terapia laser de baixa intensidade; Tissue engineering
• Link de acesso: https://www.teses.usp.br/teses/disponiveis/25/25149/tde-12052025-154918/

Tissue repair hard tissues like bone, remains a significant challenge, especially in adverse clinical conditions. Calcium hydroxyapatite (CaHA) is a calcium phosphate (CaP) with chemical and structural characteristics like the mineral structure of human teeth and bones, with bioactivity and biocompatibility properties, while photobiomodulation (PBM) utilizes light to reduce inflammation and accelerate healing. This integrative review explores the combination of CaHA and PBM, based on 25 studies from PubMed, Web of Science and ScienceDirect databases, using the keywords hydroxyapatite AND photobiomodulation, calcium hydroxyapatite AND photobiomodulation and low-level laser therapy AND calcium phosphate. In all the studies, CaHA was used for bone regeneration, and there were no reports of its use in soft tissues. The most common type of calcium-based biomaterial in the articles selected for detailed analysis was biphasic calcium phosphate, a combination of CaHA with -tricalcium phosphate (76% of the studies), while 16% of the studies did not specify the brand or product used. In the case of PBM, the most used wavelengths in the selected studies (48% of cases, with a tie at 24% for each wavelength) were devices operating with infrared lasers at 808 nm or 780 nm, with 20% of the studies not mentioning the brand or manufacturer. The results emphasize the focus on bone regeneration, indicating the need for more studies exploring soft tissue applications and establishing standardized protocols. The integration of CaHA and PBM is promising in regenerative medicine and dentistry, although more research is needed to extend its experimental and clinical use.