Prevalence of Molar Incisor Hypomineralization in children with cleft lip and palate

• Ano de defesa: 2024
• Autor(a) principal: Teixeira, Leticia Maria Pereira
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: eng
• Instituição de defesa: Biblioteca Digitais de Teses e Dissertações da USP
• Palavras-chave em Português: Cleft palate; Defeitos do esmalte dentário; Dental enamel defects; Fissura labiopalatina; Hipomineralização molar incisivo; Molar incisor hypomineralization
• Link de acesso: https://www.teses.usp.br/teses/disponiveis/25/25145/tde-31032025-173036/

Dental alterations are commonly diagnosed in children with cleft lip and palate and are linked to disorders arising from cleft-related genes, as the formation of dental germs coincides with the cleft formation period. Some alterations are often studied, but there is still limited evidence in the literature about Molar Incisor Hypomineralization (MIH) and its relationship with cleft lip and palate. Therefore, the aim of this study was to assess the prevalence of MIH in 6-12-year-old non-syndromic children with cleft lip and palate, and to compare the prevalence between 2000 and 2015 to determine if there was an increase or decrease in cases. The study was conducted in Bauru at the Pediatric Dentistry and Public Health Department of the Craniofacial Anomalies Rehabilitation Hospital (HRAC). The sample was population-based, including 478 children aged 6 to 12 with fully erupted first molars and permanent incisors. Considering the children\'s birth years, we obtained 350 children born in 2000, 22 in 2015, and 106 in the interval between those years. Data collection involved analyzing the patients\' photographic documentation available in the hospitals digital system. The examination and diagnosis were performed by two previously calibrated examiners, using the extended Ghanim et al. index for MIH. In addition to MIH, data on gender, age, defect severity, and cleft type (Spina classification, 1992) were collected. Statistical analysis was performed using multiple linear regression and chi-square tests, considering both teeth and individuals as sample units. Results showed an overall MIH prevalence of 11%, with specific prevalences of 12.6% in 2000 and 13.6% in 2015, without a statistically significant increase over time.