Cure rate models: alternatives methods to estimate the cure rate

• Ano de defesa: 2020
• Autor(a) principal: Rodrigues, Juliana Scudilio
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: eng
• Instituição de defesa: Biblioteca Digitais de Teses e Dissertações da USP
• Palavras-chave em Português: Análise de sobrevivência; Cure rate models; Defective models; Família de distribuições; Family distributions; Frailty models; Long-term survivors; Modelos de fração de cura; Modelos de fragilidade; Modelos de longa duração; Modelos defeituosos; Survival Analysis
• Link de acesso: https://www.teses.usp.br/teses/disponiveis/104/104131/tde-28092020-165703/

Cure rate models in survival data studies has formed an important field in the area and has attracted the attention of researchers. In the search for new models of cure rate, the objective of this work is to propose alternative methods to model the cure rate. For this two methods are presented. The first use the methodology of the defective models and the last method use the concept the distributions family. Then, in the first method propose the defective models induced by a frailty term. Defective models have the advantage of modeling the proportion of cured without adding any extra parameters in the model, in contrast to the most models from the literature. Models with a frailty term incorporate an unobserved heterogeneity among individuals and this incorporation brings advantages for the estimated model, because it incorporates the influence of unobserved covariates in a proportional hazard model. It is showed that the new defective distributions are induced when using the gamma frailty term. The last method proposed in this work, is to use distribution families to calculate the cure rate. For this, a parameter p is included in the Beta-G family in order to create a new family of cure rate models, the new family can be more flexible for modeling cure rate than the standard mixture models.