Estudo do efeito da administração aguda e repetida do óleo essencial de Alpinia zerumbet (OEAZ) em modelos animais de convulsão

• Ano de defesa: 2013
• Autor(a) principal: Nascimento, Nathalia Liberato
• Orientador(a): Gaspar , Danielle Macêdo
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Epilepsia; Convulsões; Anticonvulsivantes
• Link de acesso: http://www.repositorio.ufc.br/handle/riufc/7607

According to the World Health Organization (WHO, 2011), epilepsy is one of the most common serious neurological diseases, affecting over 50 million people worldwide. The main clinical manifestation of some epilepsy is seizures. Seizures can be studied in animal models by using different stimuli. The pentylenetetrazol (PTZ) is a GABA antagonist that mimics absence seizures and tonic-clonic seizure in humans. The Strychnine blocks the inhibitory response of glycine, which acts via a receptor which resembles the GABAA receptor. The Pilocarpine (PILO) is a cholinergic agonist that mimics temporal lobe epilepsy in humans. The Electroshock (ECS) is a procedure which consists in induces the generalized seizures by the passage of electric current through the brain. Alpinia zerumbet, family zingiberacea is a specie known in Brazil as colony, showing significant CNS depressant effects already studied by our research group. The present study aims to investigate the effects of acute and repeated administration of the essential oil of Alpinia zerumbet (OEAZ) in animal models of seizures in mice (males) intraperitoneally at doses of 100 and 200 mg / kg. OEAZ in the acute treatment model PTZ 85 mg / kg, showed neuroprotective effect both in seizure latency (LC) and in death latency (ML), only at dose 100 mg / kg. On the other hand, when using model ESTRIC in acute treatment, both doses studied showed anticonvulsant effect. In a model of acute PILO none of doses offered any neuroprotective effect. In ECS was observed anticonvulsant effect with respect to reducing the time of stretching, at both doses, compared to the control. However, after repeated administration for five days the OEAZ showed anticonvulsant effects in all parameters of all tests seizure-inducing studied, prolonging LC and LM when compared with the control group, this action may be directly related to the constituents of the oil, as monoterpenes.