Treinamento físico e neuroimunomodulação em modelo experimental de Tripanosomíase Americana

Detalhes bibliográficos
Ano de defesa: 2009
Autor(a) principal: Luciano Rezende Vilela
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Minas Gerais
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Tripanosomíase
Teste de esforço
Neurociências
Link de acesso: https://hdl.handle.net/1843/BUBD-8AFEXR
Resumo: In the present study we investigated the effects of physical training ontreadmill on the acute phase of Y strain T. cruzi infection in adult rats. Thetreadmill training was carried out for three weeks. We analyzed the expression of neurotrophic factors (BDNF and NGF) and cytokines (IFNã, TNFá and IL-10) in the lumbar spinal cord, sciatic nerve, skeletal muscle and serum during the acute phase of this infection. We have demonstrated by histometric analysis that physical training delays the establishment of the inflammatory process in the soleus muscle. Our results showed the occurrence of glioinflammatory nodules and parasitism of glial cells in all the infected animals submitted or notto treadmill training. We also have shown that infection the T. cruzi infection in adult rats results in increased expression of BDNF in the spinal cord. Our results indicate the importance of further studies about the effects of physical training on the experimental infection with T. cruzi in the neuromuscular system of adult rats.
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spelling Treinamento físico e neuroimunomodulação em modelo experimental de Tripanosomíase AmericanaTripanosomíaseTeste de esforçoNeurociênciasNeurociênciasIn the present study we investigated the effects of physical training ontreadmill on the acute phase of Y strain T. cruzi infection in adult rats. Thetreadmill training was carried out for three weeks. We analyzed the expression of neurotrophic factors (BDNF and NGF) and cytokines (IFNã, TNFá and IL-10) in the lumbar spinal cord, sciatic nerve, skeletal muscle and serum during the acute phase of this infection. We have demonstrated by histometric analysis that physical training delays the establishment of the inflammatory process in the soleus muscle. Our results showed the occurrence of glioinflammatory nodules and parasitism of glial cells in all the infected animals submitted or notto treadmill training. We also have shown that infection the T. cruzi infection in adult rats results in increased expression of BDNF in the spinal cord. Our results indicate the importance of further studies about the effects of physical training on the experimental infection with T. cruzi in the neuromuscular system of adult rats.Universidade Federal de Minas Gerais2019-08-13T07:03:00Z2025-09-08T23:56:13Z2019-08-13T07:03:00Z2009-11-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://hdl.handle.net/1843/BUBD-8AFEXRLuciano Rezende Vilelainfo:eu-repo/semantics/openAccessporreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG2025-09-08T23:56:13Zoai:repositorio.ufmg.br:1843/BUBD-8AFEXRRepositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2025-09-08T23:56:13Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Treinamento físico e neuroimunomodulação em modelo experimental de Tripanosomíase Americana
title Treinamento físico e neuroimunomodulação em modelo experimental de Tripanosomíase Americana
spellingShingle Treinamento físico e neuroimunomodulação em modelo experimental de Tripanosomíase Americana
Luciano Rezende Vilela
Tripanosomíase
Teste de esforço
Neurociências
Neurociências
title_short Treinamento físico e neuroimunomodulação em modelo experimental de Tripanosomíase Americana
title_full Treinamento físico e neuroimunomodulação em modelo experimental de Tripanosomíase Americana
title_fullStr Treinamento físico e neuroimunomodulação em modelo experimental de Tripanosomíase Americana
title_full_unstemmed Treinamento físico e neuroimunomodulação em modelo experimental de Tripanosomíase Americana
title_sort Treinamento físico e neuroimunomodulação em modelo experimental de Tripanosomíase Americana
author Luciano Rezende Vilela
author_facet Luciano Rezende Vilela
author_role author
dc.contributor.author.fl_str_mv Luciano Rezende Vilela
dc.subject.por.fl_str_mv Tripanosomíase
Teste de esforço
Neurociências
Neurociências
topic Tripanosomíase
Teste de esforço
Neurociências
Neurociências
description In the present study we investigated the effects of physical training ontreadmill on the acute phase of Y strain T. cruzi infection in adult rats. Thetreadmill training was carried out for three weeks. We analyzed the expression of neurotrophic factors (BDNF and NGF) and cytokines (IFNã, TNFá and IL-10) in the lumbar spinal cord, sciatic nerve, skeletal muscle and serum during the acute phase of this infection. We have demonstrated by histometric analysis that physical training delays the establishment of the inflammatory process in the soleus muscle. Our results showed the occurrence of glioinflammatory nodules and parasitism of glial cells in all the infected animals submitted or notto treadmill training. We also have shown that infection the T. cruzi infection in adult rats results in increased expression of BDNF in the spinal cord. Our results indicate the importance of further studies about the effects of physical training on the experimental infection with T. cruzi in the neuromuscular system of adult rats.
publishDate 2009
dc.date.none.fl_str_mv 2009-11-13
2019-08-13T07:03:00Z
2019-08-13T07:03:00Z
2025-09-08T23:56:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1843/BUBD-8AFEXR
url https://hdl.handle.net/1843/BUBD-8AFEXR
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv repositorio@ufmg.br
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