Papel do sistema endocanabinoide em modelos animais de ataque de pânico

Detalhes bibliográficos
Ano de defesa: 2017
Autor(a) principal: Luara Augusta da Costa e Silva Braga Batista
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Minas Gerais
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Neurociências
Link de acesso: https://hdl.handle.net/1843/BUOS-B49JSS
Resumo: The main feature of panic disorder is the occurrence of panic attacks. Pharmacological treatment is made with antidepressants and benzodiazepines. The endocannabinod system is a neurotransmitter system involved in the modulation of aversive responses. Therefore, in the present study we tested the hypothesis that this system inibits panic-like behaviors in experimental animals. In the first part, we investigated the involvement of cannabinoid receptor 1 (CB1) in the antiaversive effects induced by systemic injection of alprazolam or injection of the 5-HT1A agonist, 8-OH-DPAT, in the dorsolateral periaquedutal gray (dlPAG). In addition, we tested if increasing endocannabinoid sigaling induces panicolytic effects in the escape induced by KCN. We observed that CB1 antagonism prevented the effects of alprazolam and 8-OH-DPAT. None of the drugs tested was efficacious in the escape reaction induced by KCN, however, alprazolam presented a panicolytic effect. In the last part, we showed that doxapram induces anxiogenic efffects in the elevated T maze and cellular activation of the ventrolateral portion of the PAG. It can be concluded that the endocannabinoid system is involved in the mechanism of action of panicolytic drugs, but not in the induction of panic-like behaviors induced by KCN or doxapram. Moreover, this study suggests the utilization of the hyperventilation induced by doxapram as an animal model of panic attac
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spelling Papel do sistema endocanabinoide em modelos animais de ataque de pânicoNeurociênciasNeurociênciasThe main feature of panic disorder is the occurrence of panic attacks. Pharmacological treatment is made with antidepressants and benzodiazepines. The endocannabinod system is a neurotransmitter system involved in the modulation of aversive responses. Therefore, in the present study we tested the hypothesis that this system inibits panic-like behaviors in experimental animals. In the first part, we investigated the involvement of cannabinoid receptor 1 (CB1) in the antiaversive effects induced by systemic injection of alprazolam or injection of the 5-HT1A agonist, 8-OH-DPAT, in the dorsolateral periaquedutal gray (dlPAG). In addition, we tested if increasing endocannabinoid sigaling induces panicolytic effects in the escape induced by KCN. We observed that CB1 antagonism prevented the effects of alprazolam and 8-OH-DPAT. None of the drugs tested was efficacious in the escape reaction induced by KCN, however, alprazolam presented a panicolytic effect. In the last part, we showed that doxapram induces anxiogenic efffects in the elevated T maze and cellular activation of the ventrolateral portion of the PAG. It can be concluded that the endocannabinoid system is involved in the mechanism of action of panicolytic drugs, but not in the induction of panic-like behaviors induced by KCN or doxapram. Moreover, this study suggests the utilization of the hyperventilation induced by doxapram as an animal model of panic attacUniversidade Federal de Minas Gerais2019-08-09T23:29:08Z2025-09-08T23:32:12Z2019-08-09T23:29:08Z2017-08-18info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/1843/BUOS-B49JSSLuara Augusta da Costa e Silva Braga Batistainfo:eu-repo/semantics/openAccessporreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG2025-09-08T23:32:12Zoai:repositorio.ufmg.br:1843/BUOS-B49JSSRepositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2025-09-08T23:32:12Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Papel do sistema endocanabinoide em modelos animais de ataque de pânico
title Papel do sistema endocanabinoide em modelos animais de ataque de pânico
spellingShingle Papel do sistema endocanabinoide em modelos animais de ataque de pânico
Luara Augusta da Costa e Silva Braga Batista
Neurociências
Neurociências
title_short Papel do sistema endocanabinoide em modelos animais de ataque de pânico
title_full Papel do sistema endocanabinoide em modelos animais de ataque de pânico
title_fullStr Papel do sistema endocanabinoide em modelos animais de ataque de pânico
title_full_unstemmed Papel do sistema endocanabinoide em modelos animais de ataque de pânico
title_sort Papel do sistema endocanabinoide em modelos animais de ataque de pânico
author Luara Augusta da Costa e Silva Braga Batista
author_facet Luara Augusta da Costa e Silva Braga Batista
author_role author
dc.contributor.author.fl_str_mv Luara Augusta da Costa e Silva Braga Batista
dc.subject.por.fl_str_mv Neurociências
Neurociências
topic Neurociências
Neurociências
description The main feature of panic disorder is the occurrence of panic attacks. Pharmacological treatment is made with antidepressants and benzodiazepines. The endocannabinod system is a neurotransmitter system involved in the modulation of aversive responses. Therefore, in the present study we tested the hypothesis that this system inibits panic-like behaviors in experimental animals. In the first part, we investigated the involvement of cannabinoid receptor 1 (CB1) in the antiaversive effects induced by systemic injection of alprazolam or injection of the 5-HT1A agonist, 8-OH-DPAT, in the dorsolateral periaquedutal gray (dlPAG). In addition, we tested if increasing endocannabinoid sigaling induces panicolytic effects in the escape induced by KCN. We observed that CB1 antagonism prevented the effects of alprazolam and 8-OH-DPAT. None of the drugs tested was efficacious in the escape reaction induced by KCN, however, alprazolam presented a panicolytic effect. In the last part, we showed that doxapram induces anxiogenic efffects in the elevated T maze and cellular activation of the ventrolateral portion of the PAG. It can be concluded that the endocannabinoid system is involved in the mechanism of action of panicolytic drugs, but not in the induction of panic-like behaviors induced by KCN or doxapram. Moreover, this study suggests the utilization of the hyperventilation induced by doxapram as an animal model of panic attac
publishDate 2017
dc.date.none.fl_str_mv 2017-08-18
2019-08-09T23:29:08Z
2019-08-09T23:29:08Z
2025-09-08T23:32:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1843/BUOS-B49JSS
url https://hdl.handle.net/1843/BUOS-B49JSS
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv repositorio@ufmg.br
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