O efeito de concussões recorrentes no comportamento neuropsiquiatrico em camundongos submetidos a um protocolo de exercício físico de alta intensidade

• Ano de defesa: 2023
• Autor(a) principal: Lima, Gabriel Corrêa
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• dARK ID: ark:/26339/001300000j4dq
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; Brasil; Bioquímica; UFSM; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica; Centro de Ciências Naturais e Exatas
• Palavras-chave em Português: Concussões recorrentes; Exercício exaustivo; Esportes de contato; Na+,K+-ATPase; Recurrent concussions; Exhaustive exercise; Contact sports; CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA
• Link de acesso: http://repositorio.ufsm.br/handle/1/30809

Traumatic brain injury (TBI) affects millions of people worldwide, being one of the main causes of disability and death, with mild trauma or concussion making up more than 50% of TBI cases. Concussion is a common event in collision sports and appears to be associated with the development of long-term disorders in athletes and former athletes. The present study was designed to investigate what behavioral changes occur after a protocol for recurrent concussions associated with trained individuals. Male Swiss mice were used. Furthermore, a TBI model due to weight free fall was used, together with an exhaustive ramp running model, with the aim of mimicking elite athletes in contact sports. After the last exercise session and trauma induction, the animals underwent behavioral evaluation and euthanasia to remove the cerebral cortex. The results indicated that mice subjected to a sports-related concussion model exhibit impulsive-type behavior and an inability to maintain running intensity, discussed here as latency to fatigue. Furthermore, molecular analyzes suggest that increased neurobiological activity, indicated by increased levels of BDNF and activity of the Na+,K+-ATPase enzyme, as well as redox imbalance, possibly account for the behavioral changes acutely evidenced in the present model of associated concussion. to sport. Nevertheless, a decrease in the TrkB receptor was observed. All of these changes are independent of changes in the myeloperoxidase enzyme. Finally, changes in GAD67 levels suggest that recurrent concussions induce brain responses that are not observed when associated with strenuous exercise, thereby orienting the cerebral cortex toward a more aroused state, which partially explains our behavioral results.