Reparo da doença periodontal de ratos que realizaram terapia com zoledronato associado com a ingestão do chá verde

Detalhes bibliográficos
Ano de defesa: 2014
Autor(a) principal: Ribeiro Junior, Noé Vital lattes
Orientador(a): Saraiva, Patricia Pinto lattes
Banca de defesa: Não Informado pela instituição
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: IASCJ - Universidade Sagrado Coração
Programa de Pós-Graduação: Biologia Oral
Departamento: Ciências da Saúde e Biológicas
País: BR
Palavras-chave em Português:
bisfosfonato
doença periodontal
chá verde
zoledronato
Palavras-chave em Inglês:
bisphosphonate
periodontal disease
green tea
zoledronate
Área do conhecimento CNPq:
ODONTOLOGIA::CIRURGIA BUCO-MAXILO-FACIAL
Link de acesso: http://tede2.usc.br:8080/jspui/handle/tede/250
Resumo: The objective of this study was to understand the effects of intake of green tea on periodontal disease repair proceso (SD) induced in rats that underwent intravenous administration of zoledronate. 60 male Wistar rats divided into four groups were used: (G1) Control; (G2) zoledronate application; (G3) and green tea intake (G4) zoledronate Application and green tea intake. All animals were subjected to induction of PD. Animals in group 3 and 4 which were treated with bisphosphonates (BPs) (35 mg / kg zoledronate, intravenously). Green tea is available daily, and the DP was induced by ligation after the 3rd application of the drug. The animals were euthanized at 7, 14 and 28 days after the induction of PD. Histological analyzes, histometric and image acquisition by microtomography furcal and-bone crest were performed. Bone loss in micrometres in furcation region was similar in the control group and the green tea intake, respectively, at 7 (1078.25 ± 44.54 and 1409.02 ± 352.30), 14 (1623, 13 ± 504.74 and 1192.66 ± 448.31) and 28 days (1581.81 ± 99.38 and 1563.69 ± 270.35). When zoledronate was administered there was a protective effect of bone tissue in the initial periods, the furcation region at 7 (394.45 ± 63.38) and 14 days (683.55 ± 23.97) is similar to the other groups to 28 days (961.46 ± 284.41). The association of green tea with zoledronate promoted similar results to encontradosno grpo zoledronate, at 7 (491.11 ± 151.03), 14 (500.16 ± 103.06) and 28 days (1275.28 ± 590.68) . There was formation of bone kidnappings in the analyzed periods. The bony ridge there was no difference between groups. Therefore, green tea intake showed no influence on periodontal healing, while zoledronate acts antirreabsortiva form in PD, in the early periods, although promotes areas of bone necrosis
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spelling Saraiva, Patricia PintoCPF:14596373809http://lattes.cnpq.br/2534364772533729CPF:65081889687http://lattes.cnpq.br/8637829753219675Ribeiro Junior, Noé Vital2015-10-20T18:56:17Z2015-06-302014-12-08RIBEIRO JUNIOR, Noé Vital. Reparo da doença periodontal de ratos que realizaram terapia com zoledronato associado com a ingestão do chá verde. 2014. 35 f. Tese (Doutorado em Biologia Oral) - IASCJ - Universidade Sagrado Coração, Bauru, 2014.http://tede2.usc.br:8080/jspui/handle/tede/250The objective of this study was to understand the effects of intake of green tea on periodontal disease repair proceso (SD) induced in rats that underwent intravenous administration of zoledronate. 60 male Wistar rats divided into four groups were used: (G1) Control; (G2) zoledronate application; (G3) and green tea intake (G4) zoledronate Application and green tea intake. All animals were subjected to induction of PD. Animals in group 3 and 4 which were treated with bisphosphonates (BPs) (35 mg / kg zoledronate, intravenously). Green tea is available daily, and the DP was induced by ligation after the 3rd application of the drug. The animals were euthanized at 7, 14 and 28 days after the induction of PD. Histological analyzes, histometric and image acquisition by microtomography furcal and-bone crest were performed. Bone loss in micrometres in furcation region was similar in the control group and the green tea intake, respectively, at 7 (1078.25 ± 44.54 and 1409.02 ± 352.30), 14 (1623, 13 ± 504.74 and 1192.66 ± 448.31) and 28 days (1581.81 ± 99.38 and 1563.69 ± 270.35). When zoledronate was administered there was a protective effect of bone tissue in the initial periods, the furcation region at 7 (394.45 ± 63.38) and 14 days (683.55 ± 23.97) is similar to the other groups to 28 days (961.46 ± 284.41). The association of green tea with zoledronate promoted similar results to encontradosno grpo zoledronate, at 7 (491.11 ± 151.03), 14 (500.16 ± 103.06) and 28 days (1275.28 ± 590.68) . There was formation of bone kidnappings in the analyzed periods. The bony ridge there was no difference between groups. Therefore, green tea intake showed no influence on periodontal healing, while zoledronate acts antirreabsortiva form in PD, in the early periods, although promotes areas of bone necrosisO objetivo deste estudo foi conhecer os efeitos da ingestão do chá verde no proceso de reparo da doença periodontal (DP) induzida, em ratos que foram submetidos a administração endovenosa de zoledronato. Foram utilizados 60 ratos Wistar machos divididos em 4 grupos: (G1) Controle; (G2) Aplicação de zoledronato; (G3) Ingestão de chá verde e (G4) Aplicação de zoledronato e ingestão de chá verde. Todos os animais foram submetidos à indução da DP. Os animais do grupo 3 e 4 que foram tratados com bifosfonatos (BFs) (35 mg/kg de zoledronato, via endovenosa). O chá verde foi disponibilizado diariamente, e a DP foi induzida por ligadura, após a 3ª aplicação do medicamento. Os animais foram eutanasiados aos 7, 14 e 28 dias após a indução da DP. Foram realizadas análises histológicas, histométricas e aquisição de imagens por microtomografia da furca e crista-óssea. A perda óssea, em μm, na região de furca foi semelhante nos grupos controle e com a ingestão de chá verde, respectivamente, aos 7 (1078,25±44,54 e 1409,02±352,30), 14 (1623,13±504,74 e 1192,66±448,31) e 28 dias (1581,81±99,38 e 1563,69±270,35). Quando o zoledronato foi administrado houve um efeito protetor do tecido ósseo nos períodos iniciais, na região de furca, aos 7 (394,45±63,38) e 14 dias (683,55±23,97) sendo semelhante aos demais grupos aos 28 dias (961,46±284,41). A associação do chá verde com o zoledronato promoveu resultados semelhantes aos encontradosno grpo zoledronato, aos 7 (491,11±151,03), 14 (500,16±103,06) e 28 dias (1275,28±590,68). Houve formação de sequestros ósseos nos períodos analisados. Na crista óssea não houve diferença entre os grupos. Portanto, a ingestão de chá verde não mostrou influência sobre o reparo periodontal, enquanto o zoledronato atua de forma antirreabsortiva na DP, nos períodos iniciais, embora promova áreas de necrose ósseaMade available in DSpace on 2015-10-20T18:56:17Z (GMT). No. of bitstreams: 1 tese_noe_ribeiro junior.pdf: 1432592 bytes, checksum: 0ad94cb532a966ee1a097774fc21a509 (MD5) Previous issue date: 2014-12-08application/pdfporIASCJ - Universidade Sagrado CoraçãoBiologia OralUSCBRCiências da Saúde e Biológicasbisfosfonatodoença periodontalchá verdezoledronatobisphosphonateperiodontal diseasegreen teazoledronateODONTOLOGIA::CIRURGIA BUCO-MAXILO-FACIALReparo da doença periodontal de ratos que realizaram terapia com zoledronato associado com a ingestão do chá verdeRepair of periodontal disease in rats that underwent therapy with zoledronate associated with the intake of green teainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis8043334104093724546600600600-7534288876771829636481503023822191279info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da USCinstname:Universidade do Sagrado Coração (USC)instacron:USCORIGINALtese_noe_ribeiro junior.pdfapplication/pdf1432592http://localhost:8080/tede/bitstream/tede/250/1/tese_noe_ribeiro+junior.pdf0ad94cb532a966ee1a097774fc21a509MD51tede/2502015-10-26 10:13:29.409oai:localhost:tede/250Biblioteca Digital de Teses e Dissertaçõeshttps://tede2.usc.br:8443/http://tede2.usc.br:8080/oai/requestbiblicorjesu@unisagrado.edu.br||normalizacao@usc.bropendoar:2015-10-26T12:13:29Biblioteca Digital de Teses e Dissertações da USC - Universidade do Sagrado Coração (USC)false
dc.title.por.fl_str_mv Reparo da doença periodontal de ratos que realizaram terapia com zoledronato associado com a ingestão do chá verde
dc.title.alternative.eng.fl_str_mv Repair of periodontal disease in rats that underwent therapy with zoledronate associated with the intake of green tea
title Reparo da doença periodontal de ratos que realizaram terapia com zoledronato associado com a ingestão do chá verde
spellingShingle Reparo da doença periodontal de ratos que realizaram terapia com zoledronato associado com a ingestão do chá verde
Ribeiro Junior, Noé Vital
bisfosfonato
doença periodontal
chá verde
zoledronato
bisphosphonate
periodontal disease
green tea
zoledronate
ODONTOLOGIA::CIRURGIA BUCO-MAXILO-FACIAL
title_short Reparo da doença periodontal de ratos que realizaram terapia com zoledronato associado com a ingestão do chá verde
title_full Reparo da doença periodontal de ratos que realizaram terapia com zoledronato associado com a ingestão do chá verde
title_fullStr Reparo da doença periodontal de ratos que realizaram terapia com zoledronato associado com a ingestão do chá verde
title_full_unstemmed Reparo da doença periodontal de ratos que realizaram terapia com zoledronato associado com a ingestão do chá verde
title_sort Reparo da doença periodontal de ratos que realizaram terapia com zoledronato associado com a ingestão do chá verde
author Ribeiro Junior, Noé Vital
author_facet Ribeiro Junior, Noé Vital
author_role author
dc.contributor.advisor1.fl_str_mv Saraiva, Patricia Pinto
dc.contributor.advisor1ID.fl_str_mv CPF:14596373809
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/2534364772533729
dc.contributor.authorID.fl_str_mv CPF:65081889687
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/8637829753219675
dc.contributor.author.fl_str_mv Ribeiro Junior, Noé Vital
contributor_str_mv Saraiva, Patricia Pinto
dc.subject.por.fl_str_mv bisfosfonato
doença periodontal
chá verde
zoledronato
topic bisfosfonato
doença periodontal
chá verde
zoledronato
bisphosphonate
periodontal disease
green tea
zoledronate
ODONTOLOGIA::CIRURGIA BUCO-MAXILO-FACIAL
dc.subject.eng.fl_str_mv bisphosphonate
periodontal disease
green tea
zoledronate
dc.subject.cnpq.fl_str_mv ODONTOLOGIA::CIRURGIA BUCO-MAXILO-FACIAL
description The objective of this study was to understand the effects of intake of green tea on periodontal disease repair proceso (SD) induced in rats that underwent intravenous administration of zoledronate. 60 male Wistar rats divided into four groups were used: (G1) Control; (G2) zoledronate application; (G3) and green tea intake (G4) zoledronate Application and green tea intake. All animals were subjected to induction of PD. Animals in group 3 and 4 which were treated with bisphosphonates (BPs) (35 mg / kg zoledronate, intravenously). Green tea is available daily, and the DP was induced by ligation after the 3rd application of the drug. The animals were euthanized at 7, 14 and 28 days after the induction of PD. Histological analyzes, histometric and image acquisition by microtomography furcal and-bone crest were performed. Bone loss in micrometres in furcation region was similar in the control group and the green tea intake, respectively, at 7 (1078.25 ± 44.54 and 1409.02 ± 352.30), 14 (1623, 13 ± 504.74 and 1192.66 ± 448.31) and 28 days (1581.81 ± 99.38 and 1563.69 ± 270.35). When zoledronate was administered there was a protective effect of bone tissue in the initial periods, the furcation region at 7 (394.45 ± 63.38) and 14 days (683.55 ± 23.97) is similar to the other groups to 28 days (961.46 ± 284.41). The association of green tea with zoledronate promoted similar results to encontradosno grpo zoledronate, at 7 (491.11 ± 151.03), 14 (500.16 ± 103.06) and 28 days (1275.28 ± 590.68) . There was formation of bone kidnappings in the analyzed periods. The bony ridge there was no difference between groups. Therefore, green tea intake showed no influence on periodontal healing, while zoledronate acts antirreabsortiva form in PD, in the early periods, although promotes areas of bone necrosis
publishDate 2014
dc.date.issued.fl_str_mv 2014-12-08
dc.date.accessioned.fl_str_mv 2015-10-20T18:56:17Z
dc.date.available.fl_str_mv 2015-06-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
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status_str publishedVersion
dc.identifier.citation.fl_str_mv RIBEIRO JUNIOR, Noé Vital. Reparo da doença periodontal de ratos que realizaram terapia com zoledronato associado com a ingestão do chá verde. 2014. 35 f. Tese (Doutorado em Biologia Oral) - IASCJ - Universidade Sagrado Coração, Bauru, 2014.
dc.identifier.uri.fl_str_mv http://tede2.usc.br:8080/jspui/handle/tede/250
identifier_str_mv RIBEIRO JUNIOR, Noé Vital. Reparo da doença periodontal de ratos que realizaram terapia com zoledronato associado com a ingestão do chá verde. 2014. 35 f. Tese (Doutorado em Biologia Oral) - IASCJ - Universidade Sagrado Coração, Bauru, 2014.
url http://tede2.usc.br:8080/jspui/handle/tede/250
dc.language.iso.fl_str_mv por
language por
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dc.relation.confidence.fl_str_mv 600
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dc.relation.department.fl_str_mv -753428887677182963
dc.relation.cnpq.fl_str_mv 6481503023822191279
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv IASCJ - Universidade Sagrado Coração
dc.publisher.program.fl_str_mv Biologia Oral
dc.publisher.initials.fl_str_mv USC
dc.publisher.country.fl_str_mv BR
dc.publisher.department.fl_str_mv Ciências da Saúde e Biológicas
publisher.none.fl_str_mv IASCJ - Universidade Sagrado Coração
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reponame_str Biblioteca Digital de Teses e Dissertações da USC
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